* Corresponding Author
Isolasi Skopoletin dari Buah Mengkudu (Morinda citrifolia L) dan Uji Aktivitas Antioksidannya
https://doi.org/10.22146/agritech.9598 Sugeng Riyanto(1*), Abdul Rohman(2)
(1) Bagian Kimia Farmasi, Fakultas Farmasi Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281
(2) Bagian Kimia Farmasi, Fakultas Farmasi Universitas Gadjah Mada, Sekip Utara, Yogyakarta 55281
(*) Corresponding Author
Abstract
Scopoletin has been isolated from chloroform fraction of methanolic extract of Mengkudu fruit (Morinda citrifolia L). Its structure was confirmed using infra red spectroscopy and mass spectroscopy. Scopoletin revealed a scavenging activity of 2,2’-diphenil-1-picrylhydrazil (DPPH) radical by IC 50 348.79 μg/mL, 35 times lower than that of vitamin E (IC 50 9.77 μg/mL). Furthermore, scopoletin also showed an antioxidant activity which was lower than that of vitamin E by using linoleic-thiocyanate method.
ABSTRAK
Skopoletin telah diisolasi dari fraksi kloroform ekstrak metanol buah mengkudu (Morinda citrifolia L) yang strukturnya dikonfirmasikan dengan spektroskopi inframerah dan spektrometri massa. Skopoletin menunjukkan aktivitas penangkapan radikal 2,2’-difenil-1-pikrilhidrazil (DPPH) dengan nilai IC50 348,79 μg/mL, 35 kali lebih lemah dibandingkan dengan vitaminE (IC50 9,77 μg/mL). Skopoletin juga mempunyai aktivitas antioksidan yang lebih lemah dibandingkan dengan vitamin menggunakan metode linoleat-tiosianat.
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PDF DOI: https://doi.org/10.22146/agritech.9598
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Copyright (c) 2014 Sugeng Riyanto, Abdul Rohman
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agriTECH (print ISSN 0216-0455; online ISSN 2527-3825) is published by Faculty of Agricultural Technology, Universitas Gadjah Mada in colaboration with Indonesian Association of Food Technologies.