Hubungan Kadar Awal D-Dimer Terhadap Mortalitas pada Pasien COVID-19 Di RSUP Dr. Sardjito
Abstract
In severe COVID-19 infection, the immune response can be exaggerated and
cause a systemic cytokine storm that triggers systemic inflammatory response
syndrome (SIRS). Excessive systemic inflammatory response can lead to systemic
endothelial injury (endotheliopathy) and a hypercoagulable state that increases
the risk of systemic macrothrombosis and microthrombosis. D-dimers are
released when plasmin, a fibrinolytic enzyme, breaks down fibrin and is a
reflection of the endovascular thrombosis process. Assessment of circulating Ddimer concentrations is a sensitive test for diagnosing thrombotic status
(including pulmonary embolism and DIC) and predicting mortality event in
patient contracted with COVID- 19
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