Hubungan Kadar Awal D-Dimer Terhadap Mortalitas pada Pasien COVID-19 Di RSUP Dr. Sardjito

  • Adam Alqustar Departemen Anestesiologi dan Terapi Intensif, Fakultas Kedokteran, Kesehatan Masyarakat, dan Keperawatan, Universitas Gadjah Mada, Yogyakarta, Indonesia
  • Juni Kurniawaty Departemen Anestesiologi dan Terapi Intensif, Fakultas Kedokteran, Kesehatan Masyarakat, dan Keperawatan, Universitas Gadjah Mada, Yogyakarta, Indonesia
  • Yunita Widyastuti Departemen Anestesiologi dan Terapi Intensif, Fakultas Kedokteran, Kesehatan Masyarakat, dan Keperawatan, Universitas Gadjah Mada, Yogyakarta, Indonesia
DOI: https://doi.org/10.22146/jka.v10i1.8325
Keywords: COVID-19, D-dimer, CoagulopathY, Thrombosis, Mortality

Abstract

In severe COVID-19 infection, the immune response can be exaggerated and
cause a systemic cytokine storm that triggers systemic inflammatory response
syndrome (SIRS). Excessive systemic inflammatory response can lead to systemic
endothelial injury (endotheliopathy) and a hypercoagulable state that increases
the risk of systemic macrothrombosis and microthrombosis. D-dimers are
released when plasmin, a fibrinolytic enzyme, breaks down fibrin and is a
reflection of the endovascular thrombosis process. Assessment of circulating Ddimer concentrations is a sensitive test for diagnosing thrombotic status
(including pulmonary embolism and DIC) and predicting mortality event in
patient contracted with COVID- 19

Published
2023-05-28
How to Cite
Alqustar, A., Kurniawaty, J., & Widyastuti, Y. (2023). Hubungan Kadar Awal D-Dimer Terhadap Mortalitas pada Pasien COVID-19 Di RSUP Dr. Sardjito. Jurnal Komplikasi Anestesi, 10(1), 35-44. https://doi.org/10.22146/jka.v10i1.8325
Issue
Vol 10 No 1 (2022): Volume 10 Number 1 (2022)
Section
Articles

Copyright (c) 2022 Adam Alqustar, Juni Kurniawaty, Yunita Widyastuti

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