Efektivitas Penggunaan Asam Folat Dalam Memperbaiki Luaran Fungsional Pasien Stroke Iskemik Akut

Ratih Rakasiwi; Zullies Ikawati; Ismail Setyopranoto

doi:10.22146/farmaseutik.v18i3.66230

Efektivitas Penggunaan Asam Folat Dalam Memperbaiki Luaran Fungsional Pasien Stroke Iskemik Akut

https://doi.org/10.22146/farmaseutik.v18i3.66230

Ratih Rakasiwi⁽¹⁾, Zullies Ikawati^(2*), Ismail Setyopranoto⁽³⁾

(1) Faculty of Pharmacy, Universitas Gadjah Mada
(2) Department of Pharmacology, Faculty of Pharmacy, Universitas Gadjah Mada
(3) Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada
(*) Corresponding Author

Abstract

Hiperhomositeinemia terjadi pada pasien stroke iskemik akut dan dapat memperburuk luaran terapi karena bersifat neurotoksik. Asam folat merupakan salah satu pilihan terapi yang dapat menurunkan kadar homosistein. Studi mengenai efektivitas asam folat pada pasien stroke iskemik akut masih terbatas. Penelitian ini bertujuan untuk mengetahui efektivitas penggunaan asam folat dalam membantu memperbaiki luaran fungsional dan mengurangi durasi rawat inap pasien stroke iskemik akut. Penelitian dilakukan secara observasional-analitik dengan desain kohort retrospektif. Dari 168 pasien yang memenuhi kriteria inklusi, diperoleh 72 pasien menerima asam folat dan 96 pasien sebagai kelompok kontrol dimana tidak menerima asam folat selama rawat inap. Efektivitas penggunaan asam folat dalam membantu memperbaiki luaran fungsional diukur menggunakan skala Modified Barthel Index (MBI) dengan membandingkan perubahan skor MBI antara kedua kelompok ketika masuk rumah sakit dan ketika evaluasi pada minggu pertama perawatan. Perubahan skor MBI pada kelompok asam folat dan kelompok kontrol masing-masing sebesar 3,03±2,79 dan 2,55±2,59 (p=0,343) dengan rerata durasi rawat inap selama 7,12±1,44 dan 7,46±1,84 hari (p=0,442). Penggunaan asam folat selama pengamatan pada minggu pertama tidak signifikan secara statistik baik dalam membantu memperbaiki luaran fungsional maupun mengurangi durasi rawat inap pasien stroke iskemik akut. Penelitian lebih lanjut dengan intervensi dan pengamatan yang lebih lama hingga fase kronik (selama 3-6 bulan) perlu untuk dilakukan.

Keywords

asam folat; durasi rawat inap; luaran fungsional; stroke iskemik akut

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DOI: https://doi.org/10.22146/farmaseutik.v18i3.66230