Evaluasi Kesesuaian Dosis dan Clinical Outcome Amikasin dan Gentamisin di Bangsal Nicu (Neonatal Intensive Care Unit) RSUP Dr. Sardjito Yogyakarta

Zita Dhirani Pramono; Ika Puspitasari; Ida Safitri Laksanawati

doi:10.22146/farmaseutik.v1i1.58243

Evaluasi Kesesuaian Dosis dan Clinical Outcome Amikasin dan Gentamisin di Bangsal Nicu (Neonatal Intensive Care Unit) RSUP Dr. Sardjito Yogyakarta

https://doi.org/10.22146/farmaseutik.v1i1.58243

Zita Dhirani Pramono⁽¹⁾, Ika Puspitasari^(2*), Ida Safitri Laksanawati⁽³⁾

(1) Magister Farmasi Klinik, Fakultas Farmasi, Universitas Gadjah Mada
(2) Faculty of Pharmacy, Universitas Gadjah Mada
(3) Departemen Ilmu Kesehatan Anak, Fakultas Kedokteran, Kesehatan Masyarakat dan Keperawatan Universitas Gadjah Mada/ RSUP Dr. Sardjito, Yogyakarta
(*) Corresponding Author

Abstract

Penggunaan amikasin dan gentamisin menjadi pilihan antibiotik golongan aminoglikosida dengan indeks terapi sempit dalam terapi infeksi untuk neonatus dan penggunaannya perlu diikuti dengan monitoring terapi agar dapat mencegah toksisitas terjadi. Penelitian ini bertujuan untuk mengevaluasi kesesuaian dosis amikasin dan gentamisin pasien NICU (Neonatal Intensive Care Unit) dan mengevaluasi hasil terapinya yang dilihat dari perbaikan respon klinis pasien. Penelitian ini dilakukan dengan desain cross sectional dan dilakukan penelusuran data rekam medik pasien neonatus mendapatkan terapi amikasin atau gentamisin saat menjalani rawat inap di NICU RSUP Dr. Sardjito Yogyakarta periode 1 Januari 2017 - Desember 2018. Estimasi kadar didapatkan dari dosis pemberian dan dilakukan perhitungan farmakokinetika. Clinical outcome yang diamati yakni tanda-tanda vital dan Analisis chi square dilakukan untuk mengetahui hubungan keduanya. Pasien yang menerima amikasin dan gentamisin mengalami clinical outcome membaik berturut-turut sebanyak 18 pasien dan 28 pasien. Analisis bivariat menunjukkan tidak ada hubungan estimasi Cmax/MIC amikasin dan gentamisin terhadap clinical outcome (p 0,05). Selain itu hasil analisis bivariat pada variabel perancu didapatkan terdapat hubungan lama infeksi dan length of stay terhadap clinical outcome. Analisis multiple logistic regression didapatkan ada hubungan length of stay terhadap clinical outcome (p =0,021).

Keywords

aminoglikosida; estimasi kadar; clinical outcome; NICU

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References

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DOI: https://doi.org/10.22146/farmaseutik.v1i1.58243