OPTIMIZING FORMULA OF FAST DISINTEGRATING TABLET NATRIUM DICLOFENAC β-CYCLODEXTRIN INCLUSION COMPLEX WITH CROSPOVIDONE AS THE SUPERDISINTEGRANT AND MICROCRYSTALLINE CELLULOSE PH 102 AS THE FILLER BINDER

Wahyu Irawan; T.N. Saifullah Sulaiman

doi:10.22146/farmaseutik.v12i2.26453

OPTIMIZING FORMULA OF FAST DISINTEGRATING TABLET NATRIUM DICLOFENAC β-CYCLODEXTRIN INCLUSION COMPLEX WITH CROSPOVIDONE AS THE SUPERDISINTEGRANT AND MICROCRYSTALLINE CELLULOSE PH 102 AS THE FILLER BINDER

https://doi.org/10.22146/farmaseutik.v12i2.26453

Wahyu Irawan^(1*), T.N. Saifullah Sulaiman⁽²⁾

(1) Fakultas Farmasi, Universitas Gadjah Mada
(2) Fakultas Farmasi, Universitas Gadjah Mada
(*) Corresponding Author

Abstract

Natrium diclofenac (Na-DCF) is one of non-steroidal anti-inflammatory drug (NSAID) that have a bitter taste. The inclusion complex of NaDCF with β-cyclodextrin (BSD) can be made to mask the unpleasant taste. The inclusion complex of natrium diclofenac-β-cyclodextrin (NaDCFBSD) was prepared by spray drying method in 1:1 molar ratio. NaDCF, BSD, and NaDCF-BSD inclution complex was characterized by Fourier Transform Infrared Spectroscopy (FTIR). NaDCF-BSD complex was formulated into Fast Disintegrating Tablet (FDT) by optimizing crospovidone as superdisintegrant and microcrystalline cellulose (MCC) PH 102 as filler binder. FDTs were made by direct compression method. A respond test of taste was conducted on the FDT of optimum formula. The optimum physical properties of FDTs were produced by formulating 5,79% crospovidone and 39,21% MCC PH 102. The respond test of taste results showed that FDT with NaDCF in inclution complex have a better taste than FDT with NaDCF without inclusion complex.

Keywords

Na-diclofenac, inclution complex, fast disintegrating tablet, crospovidone, microcrystalline cellulose PH 102

Full Text:

PDF

References

Bhowmik, D., Krishnakanth, C.B., Pankaj, & Chandira, R.M., 2009, Fast Dissolving Tablet: An Overview, Journal of Chemical and Pharmaceutical Research, 1(1), 163-177. Bratu I., Astilean, S., Ionesc, C., Indrea, E., Huvenne, J.P., & Legrand, P., 1997, FT-IR and X-ray Spectroscopic Investigation of Na-diclofenac-cyclodextrin Interaction, Spectrochimica Acta Part A, 54(1998), 191-196. Buhler, V., 2008, Kollidon® Polyvinylpyrrolidone Excipients for The Pharmaceutical Industry, 9th Revised Edition, 143-203, BASF SE, Ludwigshafen. Cook, W., Quinn, M.E., & Rowe, R.C., 2009, Cyclodextrin, dalam Rowe, R.C., Sheskey P.J., & Quin, M.E., (Ed.) Handbook of Pharmaceutical Excipients, 6th Ed., 4850, Pharmaceuticals Press, Washington D.C. Davies, P. N. & Newton, J. M. 1996, Mechanical Strength, dalam Alderbon, G. & Nystrom, C. 2001, Pharmaceutical Powder and Compaction Technology, 165-191, Marcel Deker Inc., New York. Deepak, S., Dinesh, K., Mankaram, S., Gurmeet, S., & Rathore, M.S., 2012, Fast Disintegrating Tablets: A New Era in Novel Drug Delivery System and New Market Opportunities, JDDT, 2(3), 74-86. Fu, Y., Yang, S., Jeong, S.H., Kimura, S., & Park, K., 2004, Orally Fast Disintegrating Tablets: Developments, Technologies, Taste-Masking and Clinical Studies. Guy, 2009, Cellulose, Microcrystalline, dalam Rowe, R.C., Sheskey P.J., & Quin, M.E., (Ed.) Handbook of Pharmaceutical Excipients, 6th ed., 129-133, Pharmaceuticals Press, Washington D.C. Hasegawa, M., 2002, Direct Compression Microcrystalline Sellulose Grade 12 versus Classic Grade 102, Pharmaceutical Technology, 50-60. Kibbe, A.H., 2009, Crospovidone, dalam Rowe, R.C., Sheskey P.J., & Quin, M.E., (Ed.) Handbook of Pharmaceutical Excipients, 6th ed., 4850, Pharmaceuticals Press, Washington D.C. Mangal, M., Thakral, S., Goswami, M., & Ghal P., 2012, Superdisintegrants: An Updated Review, International Journal of Pharmacy and Pharamaceutical Science Research, 2(2), 26-35. Nilesh, M.R., Shivaji, D.M., & Rameshrao, K.D., 2012, Taste Masking Method and Agents in Pharmaceutical Formulations, IRJP, 3(8), 67-70. Novartis, 2009,Voltaren ®-XR Technical Brochure, Novartis Pharma Stein AG,Stein Panigrahi R., & Behera, S., 2010, A Review of Fast Dissolving Tablets, WebmedCentral, 1(9), 117. Shankarrao, K.A., Mahadeo, G.D., & Balavantrao K.P., 2010, Formulation and In-Vitro Evaluation of Orally Disintegrating Tablet of Ilanzapine-2-Hydroxypropyl-β-Cyclodextrin Inclusion Complex, http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3870057/, 8 Desember 2014. Sharma, S., & Lewis, S., 2010, Taste Masking Technologies: A Review, International Journal of Pharmacy and Pharmaceutical Sciences, 2(2), 6-13.

DOI: https://doi.org/10.22146/farmaseutik.v12i2.26453