Apakah Endometriosis Mempengaruhi Kualitas Embryo pada Pasien Invitro Fertilization?
Dewanto Suryoningrat(1*), Abdurahman Laqif(2), Soetrisno Soetrisno(3), Uki Retno Budihastuti(4), Sri Sulistyowati(5)
(1) Sebelas Maret University
(2) Sebelas Maret University
(3) Sebelas Maret University
(4) Sebelas Maret University
(5) Sebelas Maret University
(*) Corresponding Author
Abstract
Latar Belakang Invitro Fertilization merupakan salah satu manajemen infertilitas yang baik, namun masih didapatkan adanya kesamaan peluang kegagalan perkembangan embrio sebanyak 50% dibandingkan dengan pasien yang tidak mengalami endometriosis.
Tujuan: untuk mengetahui hubungan endometriosis dan kualitas embrio pada pasien yang menjalani program invitro fertilization.
Metode: Data yang dikumpulkan merupakan data pada rekam medis pasien Klinik Fertilitas Sekar yang menjalani invitro fertilization di Klinik Fertilitas Sekar RSUD Dr. Moewardi Surakarta pada Januari 2010 – Desember 2019. Analisis menggunakan uji deskriptif dan Uji T tidak berpasangan. Hasil dianggap signifikan jika p ≤ 0,05.
Hasil dan Pembahasan: Dalam penelitian ini, rerata kualitas embrio baik memiliki perbedaan yang signifikan (p<0.05) antara pasien dengan endometriosis dan pasien tanpa endometriosi, sedangkan kualitas embrio buruk tidak memiliki perbedaan yang signifikan (p>0.05).
Kesimpulan: Endometriosis memiliki hubungan yang signifikan dengan kualitas embrio pada wanita yang menjalani program IVF.
Keywords
Full Text:
PDFReferences
- Evans, M. B. and Decherney, A. H. ‘Fertility and Endometriosis’, Clinical Obstetrics and Gynecology 2017 ,60(3), pp. 497–502.
- Jamaan T., Boediono A., Pakasi T A., Moeloek F A., ‘Improving the probability of pregnancy in endometriosis cases: A study in patients undergoing in vitro fertilization’, Medical Journal of Indonesia 2012, 21(3), pp. 147–151
- Da Broi, M. G. and Navarro, P. A. ‘Oxidative stress and oocyte quality: ethiopathogenic mechanisms of minimal/mild endometriosis-related infertility’, Cell and Tissue Research 2016, 364(1).
- Singh, N., Lata, K., Naha, M., Malhotra, N., Tiwari, A., Vanamail, P. ‘Effect of endometriosis on implantation rates when compared to tubal factor in fresh non donor in vitro fertilization cycles’, Journal of Human Reproductive Sciences 2014, 7(2), pp. 143–147.
- Sanchez, Ana M., Pagliardini, L., Cermisoni, Greta C., Privitera, L., Makieva, S., Alteri, A., et al. ‘Does endometriosis influence the embryo quality and/or development? Insights from a large retrospective matched cohort study’, Diagnostics 2020, 10(2).
- Cohen, J., Ziyyat, A., Naoura, I., Chabbert-Buffet, N., Aractingi, S., Darai, E., & Lefevre, B. Effect of induced peritoneal endometriosis on oocyte and embryo quality in a mouse model. Journal of Assisted Reproduction and Genetics 2014, 32(2), 263–270.
- Gardner, D. K. and Balaban, B. ‘Assessment of human embryo development using morphological criteria in an era of time-lapse, algorithms and “OMICS”: Is looking good still important?’, Molecular Human Reproduction 2016, 22(10), pp. 704–718.
- Borges, E., Braga, D. P., Setti, A. S., Figueira, R. C., Pasqualotto, F. F., & Iaconelli, A ‘The influence of endometriosis on oocyte quality and embryo developmental competence’, Fertility and Sterility 2015, 104(3), pp. e201–e202.
- Pellicer A, Albert C, Garrido N, Navarro J, Remohí J, Simón C. The pathophysiology of endometriosis-associated infertility: follicular environment and embryo quality. Journal of Reproduction and fertility. Supplement. 2000 ;55:109-119.
- Chapron, C. Marcellin L., Borghese B., Santulli P ‘Rethinking mechanisms, diagnosis and management of endometriosis’, Nature Reviews Endocrinology 2019. Springer US, 15(11), pp. 666–682.
- Donnez J, Donnez O, Orellana R, Binda MM, Dolmans MM. Endometriosis and infertility. Panminerva Med. 2016;58(2):143-150.
- Sanchez, A M., Vanni, V S., Bartiromo, L., Papaleo, E., Zilberberg, E., Candiani, M., et al. ‘Is the oocyte quality affected by endometriosis? A review of the literature’, Journal of Ovarian Research 2017. Journal of Ovarian Research, 10(1), pp. 1–11.
- Xu, B., Guo, N., Zhang, X., Shi, W., Tong, X., Iqbal, F., & Liu, Y. ‘Oocyte quality is decreased in women with minimal or mild endometriosis’, Scientific Reports 2015, 5, pp. 1–8.
- Al-Fadhli, R., Kelly, S. M., Tulandi, T., & Lin Tan, S ‘Effects of Different Stages of Endometriosis on the Outcome of In Vitro Fertilization’, Journal of Obstetrics and Gynaecology Canada. Elsevier Masson SAS 2006, 28(10), pp. 888–891
DOI: https://doi.org/10.22146/jkr.63039
Article Metrics
Abstract views : 2694 | views : 2992Refbacks
Copyright (c) 2021 The Author(s)
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
SEKRETARIAT JURNAL KESEHATAN REPRODUKSI
Departemen Obstetri dan Ginekologi, FK-KMK, UGM/RS Dr. Sardjito
Jl. Kesehatan No. 1, Sekip Utara, Yogyakarta 55281
Tlp: (0274) 511329 / Faks: (0274) 544003
Email: jurnal.kesehatanreproduksi@ugm.ac.id
Cp: Dwi Astuti +6281802698043