Studi Literatur Perbedaan Ekspresi Messenger Ribonucleid Acid (mRNA) Reseptor Androgen Setelah Pemberian Testosteron antara Penis dan Kelenjar Prostat Tikus Wistar Jantan (Rattus Norvegicus) Pascakastrasi

https://doi.org/10.22146/jkr.37823

Luh Ari Arini(1*)

(1) Jurusan D3 Kebidanan, Fakultas Olahraga dan Kesehatan, Universitas Pendidikan Ganesha
(*) Corresponding Author

Abstract


Background: Aging process (andropause) in men will cause a decrease in testosterone hormones, in other that decrese of androgen receptor (testosteron and dhyhidrtestosterone) in target organ, can be seen from AR mRNA expression. Andropause finaly impact of male reproductive organ, so given testosterone hormone therapy is important to restore the condition. Giving testosterone hormone causes increase the expression of AR mRNA in the prostate gland and penis, but in these two organs there is a different increase.
Objective: to know the difference of expression AR mRNA after administration of testosterone between prostate gland and penis.
Method: This article used literature review from database of intisari sains medis.
Results and Discussion: AR mRNA expression in the prostate gland is smaller than the penile tissue, due to the prostate gland in addition to the 5α reductase enzyme there are also many aromatase enzymes. In the normal prostate gland the amount of 5α reductase is small, so the addition of testosterone is converted to DHT but also in aromatization to estrogen. Therefore, fewer androgen receptors are found compared to the tissue of the penis, in addition expression of AR mRNA in the preputial penis is higher than the prostate gland.
Conclusion: Penile tissue is more responsive to testosterone and improves the function and maintenance of tissue especially in old. Keywords: androgen receptor mRNA; testosterone; penis and prostate

Keywords


mRNA reseptor androgen; testosteron; penis dan prostat

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References

  1. Adesanya, O., Oluyemi, K., Dare, N., Shittu, L., Oyesola, O. Okanlawon, A. 2007. Sex Steroid Induced Changes On The Morphology Of Prostate Of Sparague-Dawley Rats. Scientific Research And Essay, 2(8): 309-314.
  2. Akmal, M. 2017. Androgen Dihydrotestosterone Dan Perannya Pada Sisitem Reproduksi Pria. Laboratorium Histologi FKH Universitas Syiah Kuala. Veterina Medika, Vol 10 No 1: 119-127.
  3. Arini, L.A. 2016. Pemberian Testosterone Replacement Therapy Meningkatkan Ekspresi mRNA Reseptor Androgen pada Kelenjar Prostat Tikus Wistar (Rattus norvegicus) Jantan yang Dikastrasi. Intisari Sains Medis, 7(1): 83-88.
  4. Banerjee, P., Banerjee, S., Brown, T. 2001. Increased Androgen Receptor Expression Correlates With Development Of Age Dependent, Lobe-Specific Spontaneous Hyperplasia Of Rat Prostate. Endocrinology, 142: 4075-4066.
  5. Borst, S., Mulligan, T. 2007. Testosterone Replacement Therapy For Older Men. Clinical Interventions In Aging. PMC. NCBI, 4(2): 328-322.
  6. Christoforou, P. Christopoulos, P.F. Koutsilieris, M. 2014. The Role Of Estrogen Receptor β In Prostate Cancer. Molecular Medicine J, 20(10): 427-434.
  7. Cunningham, R., Hijazi, A., Glenn. 2004. Androgen Replacement Therapy Indicated For The Aging Male. Departments Of Medicine And Molecular And Cellular Biology, Baylor College Of Medicine And VA Medical Center, Houston. Annual Review, 56:137-117.
  8. Ellem, S., Schmitt, J., Pedersen, J., Frydenberg, M., Risbridger, P. 2004. Local Aromatase Expression In Human Prostate Is Altered In Malignancy. Pubmed. NCBI. J Clin Endocrinol Metab, 89(5): 2434-2441.
  9. Ellem, S., Risbridger, G. 2006. Aromatase And Prostate Cancer. Minerva Endocrinol, 31(1): 1-12.
  10. Fournier, P., Boissier, S., Filleur, S., Guglielmi, J., Cabon, F., Colombel, M., Clezardin, P. 2002. Bisphosphonates Inhibit Anggiogenesis In Vitro And Testosterone-Stimulated Vascular Regrowth In The Ventral Prostate In Castrated Rats. Cancer Research, 62:. 6538-6544.
  11. Gao, N., Ishii, K., Mirosevich, J., Kuwajima, S., Stacey, R., Richard, L., Jiang, M., Scott, B., Richard, M., Stoffel, M. 2005. Article Forkhead Box A1 Regulates Prostate Ductal Morphogenesis And Promotes Epithelial Cell Maturation. Company Of Biologists., 28:127-125.
  12. George, G., Kuiper., Enmark, E., Pelto, M., Nilsson, S., Gustaffon, J. 1996. Cloning Of a Novel Estrogen Receptor Expressed In Rat Prostate And Ovary. Proc Natl Acad Sci USA. Biochemistry, 93: 5925-5930.
  13. Jesmin, S., Chishimba, N., Mowa., Matsuda, N., Salah-Eldin, A.,Togashi, H., Sakuma, I., Hattori, Y., Kitabatake. 2002. Evidence For a Potential Role Of Estrogen In The Penis: Detection Of Estrogen Receptor And Messenger Ribonucleic Acid And Protein. Endocrinology, 143(12): 4764–4774.
  14. Justulin, J., Rodrigo, L, Ureshino, P., Michelle, Z., Felisbino, S. 2006. Differential Proliferative Response Of The Ventral Prostate And Seminal Vesicle To Testosterone Replacement. International Federation For Cell Elseiver Ltd. Biology, 30: 364-354.
  15. Koryakina, Y., Ta, H., Gioeli, D. 2014. Androgen Receptor Phosphorylation: Biological Context And Functional Consequences. Endocrine-Related Cancer. 21: 131-145.
  16. Laurence, S., Baskin, R., Michael, S., Simon, S., Joshua, W., Gerald, R., Cunha. 1997. The Effect Of Testosterone On Androgen Receptors And Human Penile Growth. The Journal Of Urology, 158(3): 1113-1118.
  17. Leav, I., Lau, M., Adams, Y., Mcneal, E., Taplin, E., Wang, J., Singh, H., Ho, M.,. 2001. Comparative Studies Of The Estrogen Receptors Beta And Alpha And The Androgen Receptor In Normal Human Prostate Glands, Dysplasia, And In Primary And Metastatic Carcinoma. Am J Pathol, 159: 79-92.
  18. Li, Y., Izumi, K., Miyamato, H. 2012. The Role Of The Androgen Receptor In The Development And Progression Of Bladder Cancer. Jpn J Clin Oncol, 42(7): 569-577.
  19. Mark, L., Mazer, N., Mostaghel, E., Hess, D., Dorey, F. 2006. Effect Of Testosterone Replacement Therapy On Prostate Tissue In Men Wiht Late-Onset Hypogonadism: a Randomized Controlled Trial. Jama, 296(19): 2351-2361.
  20. Matsumoto, T., Sakari, M., Okada, M., Yokoyama, A., Takahashi, S., Kouzmenko, A., Kato, S. 2013. The Androgen Receptor In Health And Disease. Annual Review Of Physiology, 75: 201-224.
  21. Mcpherson, J., Ellem, J., Simpson, R., Patchev, V., Fritzemeier, H., Risbridger, P. 2007. Essential Role For Estrogen Receptor Beta In Stromal-Epithelial Regulation Of Prostatic Hyperplasia. Endocrinology, 148: 566-574.
  22. Nestor, F., Cadavid, G., Swerdloff, R., Lemmi, C., Rajfer, J. 1991. Expression Of The Androgen Receptor Gene In Rat Penile Tissue And Cells During Sexual Maturation. The Journal Of Urology.Endocrinology,129(3):1671–1678.
  23. Nieschlag, E., Swerdloff, R., Behre, H.M. 2005. Investigation, Treatment, And Monitoring Of Late-Onset Hypogonadism In Males: ISA, ISSAM, And EAU Recommendations. Int Journal Of Andrology, 28:125-127.
  24. Prakash, C., Supakar, Chung, S., Song, M., Jung, M., Slomczynska, J., Kim, R., Vellanoweth, B., Adrun, K. 2003. A Novel Regulatory Element Associated With Age Dependent Expression Of The Rat Androgen Receptor Gen. The Journal Of Biological Chemistry, 268(35): 2610-2640.
  25. Rahayu, N.P. 2016. Terapi Sulih Testosteron Meningkatkan Ekspresi Messenger Ribonucleaic Acid (mRNA) Reseptor Androgen Pada Penis Tikus Wistar (Rattus Norvegicus) Dewasa Yang Dikastrasi. Directory Of Open Access Journal. Intisari Sains Medis, 7(1): 76-80.
  26. Risbridger, G., Ellem, S., Mcpherson, S., 2007. Review Article Estrogen Action In Prostate Gland: a Critical Mix Of Endocrine And Paracrine Signaling. Journal Of Molecular Endocrinology, 39:183-188.
  27. Risbridger, G., Ellem, S. 2010. Aromatase And Regulating The Estrogen: Androgen Ratio In The Prostate Gland. Journal Of Steroid Biochemistry And Molecular Biology, 118: 246-251.
  28. Saalu, L., Osinubi, A. 2013. Andropause (Male Menopause): Valid Concepts, Fables And Controversies. Journal Of Basic Medical Sciences, 1(1): 33-37.
  29. Sansal, I., Sellers, R. 2004. The Biology And Clinical Relevance Of The PTEN Tumor Suppressor Pathway. J Clin Oncol, 22: 2954-2963.
  30. Sakka, AI., Yassin, A. 2010. Amelioration Of Penile Fibrosis: Myth Or Reality. Journal Of Andrology, 31: 324-334.
  31. Schultheiss, D., Badalyan, R., Pilatz, A., Gabouev, A., Schlote, N., Wefer, J. Wasielewski., R.Mertsching, H., Shon, M., Stief, C., Jonas, U. 2003. Androgen And Estrogen Receptors In The Human Corpus Cavernosum Penis: Immunohistochemical And Cell Culture Results. World Journal Of Urology, 21(5): 320–324.
  32. Shidaifat, F. 2009. Age-Dependent Expression Of 5α reductase And Androgen Receptors mRNA By The Canine Prostate. Department Of Basic Veterinary Medical Sciences, Faculty Of Veterinary Medicine. Jordan. Physiol. Res, 58: 1558-158.
  33. Slusarz, A., Jackson, G., Day, J., Shenouda, N., Bogener, J., Browning, J., Fritsche, K., Macdonald, R., Williford, C., Lubahn, D. 2012. Aggressive Prostate Cancer Is Prevented In ERα Alphako Mice And Stimulated In ERβko TRAMP Mice. Endocrinology J,153:4160-4170.
  34. Soetojo, D. 2004. Pengaruh Pemberian Kombinasi 5 Redukatse Inhibitor Dan Estrogen Pada Proliferasi Jaringan Prostat. Disertasi Thesis Universitas Airlangga.
  35. Tan, M., Li, J., Xu, H., Melcher, K., Yong, E. 2015. Androgen Receptor: Structure, Role In Prostate Cancer And Drug Discovery. Acta Pharmacologica Sinica, 36: 3-23.
  36. Thomas, L., Douglas, R., Lazier, C., Too, C., Rittmaster, R., Tindall, D. 2008. Type 1 And Type 2 5alpha-Reductase Expression In The Development And Progression Of Prostate Cancer. Eur Urol, 53: 244-52.
  37. Toress-Estay, V., Carreno, V., Sanfrancisco, F., Sotomayor, P., Godoy, A., Smith, G. 2015. Androgen Receptor In Human Endhotelial Celss. Journal Of Endocrinology, 224: 131-137.
  38. Weihua, Z., Lathe, R., Warner, M., Gustafsson, J. 2002. An Endocrine Pathway In The Prostate, Erβ, AR, 5α-Androstane-3β, 17β-Diol, And CYP7B1, Regulates Prosatate Growth. Proc Natl Acad Sci USA, 99:13589-13594.
  39. Vermeulen, A., Kaufman, M., Goemaere, S., Van, P. 2002. Estradiol In Elderly Men. Aging Male, 5: 98-102.
  40. William, D.2001. 5 Alpha Reductase Activity In The Prostate. Urology, 58(06): 24-27.
  41. Wolf, D., Herzingert, T., Hermeking, H. 2003. Transcriptional And Postranscriptional Regulation Of Human Androgen Receptor Expression. Molecular Endocrinology, 7: 924-936.
  42. Xinchang, Z. 2010. Roles Of Androgen Receptor In Male And Female Reproduction Lesson From Global And Cell Specific Androgen Receptor Knock Out (ARKO) Mice. Journal Of Andrology, 31:3.
  43. Yan, MM., Wa, K,. Qiang, D., Qi, S., Yang, G. 2014. Testosterone Regulates Keratin 33B Expression In Rat Penis Growth Through Androgen Receptor Signaling. Asian J Androl, 16(6): 23-817.
  44. Yeh, C., Da, Jun., Song, W., Fazili, A., Yeh, S. 2014. Review Article Estrogen Receptors In Prostate Development And Cancer. Department Of Urology. Am J Clin Exp Urology, 2(2):161-168.



DOI: https://doi.org/10.22146/jkr.37823

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