In Vivo Evaluation of Heavy Metal Decontaminated Marine Macroalgae (Ulva lactuca L.) Using Bilimbi (Averrhoa bilimbi) Juice and Its Potency As Nephroprotector

https://doi.org/10.22146/ifnp.85312

Ashfiya Hanif Hasnadewi(1*), Mulyati Mulyati(2), Ardaning Nuriliani(3), Fajar Sofyantoro(4)

(1) Faculty of Biology, Universitas Gadjah Mada
(2) Faculty of Biology, Universitas Gadjah Mada
(3) Faculty of Biology, Universitas Gadjah Mada
(4) Faculty of Biology, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Ulva lactuca is a functional food ingredient with high antioxidant content. The presence of heavy metal contaminants in natural Ulva lactuca needs to be eliminated. Ulva lactuca was investigated for its potential as a nephroprotector in female Wistar rats. The study assessed Blood Urea Nitrogen (BUN) levels, creatinine levels, and kidney histopathology. The experiment included a Group I (control), Group II (administered 1000 mg/Kg BW/day of natural Ulva lactuca), and Group III (administered 1000 mg/Kg BW/day of heavy metal decontaminated Ulva lactuca using bilimbi juice). After 30 days of oral treatment, no significant differences were observed in BUN levels before and after treatment. However, significant variations were found in Group III compared to the Group I creatinine levels after treatment. Both natural and heavy metal decontaminated Ulva lactuca showed no adverse effects on kidney function. Notably, heavy metal decontaminated Ulva lactuca exhibited improved kidney histopathology, suggesting its potential as a nephroprotector. Further research is needed to explore its broader applications in promoting kidney health.


Keywords


BUN, creatinine, nephroprotector, Ulva lactuca, Wistar rat

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DOI: https://doi.org/10.22146/ifnp.85312

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Indonesian Food and Nutrition Progress (print ISSN 0854-6177, online ISSN 2597-9388) is published by the Indonesian Association of Food Technologist in collaboration with Department of Food and Agricultural Product Technology, Faculty of Agricultural Technology, Universitas Gadjah Mada.

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