Bioactivity of Fucoxanthin From Brown Seaweed as Antioxidant and Anti-melanogenesis: A Narrative Review
Keywords:
Brown algae, fucoxanthin, whitening, cosmetics, anti-melanogenesis, tyrosinase
Abstract
Whitening cosmetics with anti melanogenesis activity are very popular in the world. Many studies are trying to identity new ingredients that exhibit antimelanogenesis effect for the developing of new products. There has been a rapid increase in the use of natural anti hyperpigmentation agents from marine sources for pharmaceutical and cosmetic applications. The aims of this review is to provide an overview of the antioxidant and anti melanogenesis effect of brown seaweed which contains a large amount of fucoxanthin as a skin whitening agent. Fucoxanthin from brown algae sources has also developed for use in cosmetics. Most of the articles we reviewed lack detailed investigations of molecular target, which are essential for meeting the criteria of cosmetic and pharmaceutical use. Recently, several carotenoids have been discovered from brown seaweed by examining their anti-melanogenesis and mechanisms. Despite the rarity of in vivo and clinical investigations of marine molecular mechanism algae derivates whitening agents. The novelty of this review is to discuss fucoxanthin as a major carotenoid in brown algae as an antioxidant and anti-melanogenesis. An anti-melanogenesis test is generally preceded by an antioxidants activity test. Almost all brown algae have a good antioxidant effect (compared to control). This suggests that brown seaweed has antioxidant properties. In addition, the melanogenesis effecf of brown algae was better compared to the control
References
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Zhao, D., Kwon, S.H., Chun, Y.S., Gu, M.Y., and Yang, H.O., 2017, Anti-Neuroinflammatory Effects of Fucoxanthin via Inhibition of Akt/NF-κB and MAPKs/AP-1 Pathways and Activation of PKA/CREB Pathway in Lipopolysaccharide-Activated BV-2 Microglial Cells, Neurochem. Res., 42, 667–677.
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Aditya, N.W., 2020, The effect of fucoxanthin as coloring agent on the quality of catfish sausage, IOP Conf. Ser. Earth Environ. Sci., 441, .
Agregán, R., Munekata, P.E.S., Franco, D., Dominguez, R., Carballo, J., and Lorenzo, J.M., 2017, Phenolic compounds from three brown seaweed species using LC-DAD–ESI-MS/MS, Food Res. Int., 99, 979–985.
Alghazwi, M., Smid, S., Musgrave, I., and Zhang, W., 2019, In vitro studies of the neuroprotective activities of astaxanthin and fucoxanthin against amyloid beta (Aβ 1-42 ) toxicity and aggregation, Neurochem. Int., 124, 215–224.
Arguelles, E., 2021, Evaluation of Antioxidant Capacity, Tyrosinase Inhibition, and Antibacterial Activities of Brown Seaweed, Sargassum ilicifolium (Turner) C. Agardh 1820 for …, J. Fish. Environ., 45, 64–78.
Arguelles, E. and Sapin, A.B., 2020, Bioprospecting of turbinaria ornata (Fucales, phaeophyceae) for cosmetic application: Antioxidant, tyrosinase inhibition and antibacterial activities, J. ISSAAS, 1–15.
Azam, M.S., Joung, E.J., Choi, J., and Kim, H.R., 2017, Ethanolic extract from Sargassum serratifolium attenuates hyperpigmentation through CREB/ERK signaling pathways in α-MSH-stimulated B16F10 melanoma cells, J. Appl. Phycol., 29, 2089–2096.
Chan, Y.Y., Kim, K.H., and Cheah, S.H., 2011, Inhibitory effects of Sargassum polycystum on tyrosinase activity and melanin formation in B16F10 murine melanoma cells, J. Ethnopharmacol., 137, 1183–1188.
d’Ischia, M., Wakamatsu, K., Cicoira, F., Di Mauro, E., Garcia-Borron, J.C., Commo, S., Galván, I., Ghanem, G., Kenzo, K., Meredith, P., Pezzella, A., Santato, C., Sarna, T., Simon, J.D., Zecca, L., Zucca, F.A., Napolitano, A., and Ito, S., 2015, Melanins and melanogenesis: From pigment cells to human health and technological applications, Pigment Cell Melanoma Res., 28, 520–544.
Foo, S.C., Yusoff, F.M., Ismail, M., Basri, M., Yau, S.K., Khong, N.M.H., Chan, K.W., and Ebrahimi, M., 2017, Antioxidant capacities of fucoxanthin-producing algae as influenced by their carotenoid and phenolic contents, J. Biotechnol., 241, 175–183.
Gao, F., Teles (Cabanelas, ITD), I., Wijffels, R.H., and Barbosa, M.J., 2020, Process optimization of fucoxanthin production with Tisochrysis lutea, Bioresour. Technol., 315, .
Gulcin, İ., 2020, Antioxidants and antioxidant methods: an updated overview,.
Guvatova, Z., Dalina, A., Marusich, E., Pudova, E., Snezhkina, A., Krasnov, G., Kudryavtseva, A., Leonov, S., and Moskalev, A., 2020, Protective effects of carotenoid fucoxanthin in fibroblasts cellular senescence, Mech. Ageing Dev., 189, 111260.
Harrysson, H., Hayes, M., Eimer, F., Carlsson, N.G., Toth, G.B., and Undeland, I., 2018, Production of protein extracts from Swedish red, green, and brown seaweeds, Porphyra umbilicalis Kützing, Ulva lactuca Linnaeus, and Saccharina latissima (Linnaeus) J. V. Lamouroux using three different methods, J. Appl. Phycol., 30, 3565–3580.
Hassan, I.H., Pham, H.N.T., and ..., 2021, Optimization of ultrasound‐assisted extraction conditions for phenolics, antioxidant, and tyrosinase inhibitory activities of Vietnamese brown seaweed (Padina …, J. Food Process.
Karpiński, T.M., 2019, Fucoxanthin—an antibacterial carotenoid, Antioxidants, 8, .
Kim, C.S., Noh, S.G., Park, Y., Kang, D., Chun, P., Chung, H.Y., Jung, H.J., and Moon, H.R., 2018, A Potent Tyrosinase Inhibitor, (E)-3-(2,4-Dihydroxyphenyl)-1-(thiophen-2-yl)prop-2-en-1-one, with Anti-Melanogenesis Properties in α-MSH and IBMX-Induced B16F10 Melanoma Cells, Molecules, 23, 1–15.
Kim, M., Kim, D.S., Yoon, H., Lee, W.J., Lee, N.H., and Hyun, C., 2014, Melanogenesis inhibitory activity of Korean Undaria pinnatifida in mouse B16 melanoma cells,7, 89–92.
Kim, S., 2021, Antioxidant activity and cell bioactivity of Sargassum macrocarpum extract, J. Korea Converg. Soc.,.
Ktari, L., 2021, Fucoxanthin and Phenolic Contents of Six Dictyotales From the Tunisian Coasts With an Emphasis for a Green Extraction Using a Supercritical CO
Liang, D., Liu, C., Li, Y., Wu, C., Chen, Y., Tan, M., and Su, W., 2023, Engineering fucoxanthin-loaded probiotics’ membrane vesicles for the dietary intervention of colitis, Biomaterials, 297, .
Lim, H.-S., Jin, S., and Yun, S.J., 2016, Modulation of Melanogenesis by Heme Oxygenase-1 via p53 in Normal Human Melanocytes, Chonnam Med. J., 52, 45.
Liu, B., Xie, Y., and Wu, Z., 2020, Astragaloside IV Enhances Melanogenesis via the AhR-Dependent AKT/GSK-3 β/β-Catenin Pathway in Normal Human Epidermal Melanocytes, Evidence-based Complement. Altern. Med., 2020, .
Lourenço-Lopes, C., Fraga-Corral, M., Jimenez-Lopez, C., Carpena, M., Pereira, A.G., Garcia-Oliveira, P., Prieto, M.A., and Simal-Gandara, J., 2021, Biological action mechanisms of fucoxanthin extracted from algae for application in food and cosmetic industries, Trends Food Sci. Technol., 117, 163–181.
Maeda, H., 2018, Anti-oxidant and fucoxanthin contents of brown alga ishimozuku (Sphaerotrichia divaricata) from the west coast of aomori, Japan, Mar. Drugs, 16, .
Méresse, S., Fodil, M., Fleury, F., and Chénais, B., 2020, Fucoxanthin, a Marine-Derived Carotenoid from Brown Seaweeds and Microalgae: A Promising Bioactive Compound for Cancer Therapy, Int. J. Mol. Sci., 21, .
Miyashita, K., Beppu, F., Hosokawa, M., Liu, X., and Wang, S., 2020, Nutraceutical characteristics of the brown seaweed carotenoid fucoxanthin, Arch. Biochem. Biophys., 686, 108364.
Mok, I.K., Lee, J.K., Kim, J.H., Pan, C.H., and Kim, S.M., 2018, Fucoxanthin bioavailability from fucoxanthin-fortified milk: In vivo and in vitro study, Food Chem., 258, 79–86.
Motshakeri, M., Ebrahimi, M., Goh, Y.M., Othman, H.H., Hair-Bejo, M., and Mohamed, S., 2014, Effects of brown seaweed (sargassum polycystum) extracts on kidney, liver, and pancreas of type 2 diabetic rat model, Evidence-based Complement. Altern. Med., 2014, .
Mourelle, M.L., Gómez, C.P., and ..., 2021, Role of Algal Derived Compounds in Pharmaceuticals and Cosmetics, Recent Adv. Micro …,.
Namjooyan, F, Farasat, M., Alishahi, M., and ..., 2019, The anti-melanogenesis activities of some selected brown macroalgae from northern coasts of the Persian Gulf, Brazilian Arch. …,.
Namjooyan, Foroogh, Farasat, M., Alishahi, M., Jahangiri, A., and Mousavi, H., 2019, The anti-melanogenesis activities of some selected brown macroalgae from northern coasts of the persian gulf, Brazilian Arch. Biol. Technol., 62, 383–390.
Nurrochmad, A., Wirasti, W., Dirman, A., Lukitaningsih, E., Rahmawati, A., and Fakhrudin, N., 2018, Effects of Antioxidant, Anti-Collagenase, Anti-Elastase, Anti-Tyrosinase of The Extract and Fraction From Turbinaria decurrens Bory., Indones. J. Pharm., 29, 188.
Petrushkina, M., Gusev, E., Sorokin, B., Zotko, N., Mamaeva, A., Filimonova, A., Kulikovskiy, M., Maltsev, Y., Yampolsky, I., Guglya, E., Vinokurov, V., Namsaraev, Z., and Kuzmin, D., 2017, Fucoxanthin production by heterokont microalgae, Algal Res., 24, 387–393.
Rajauria, G., 2019, In-vitro antioxidant properties of lipophilic antioxidant compounds from 3 brown seaweed, Antioxidants, 8, .
Rajauria, G., Foley, B., and Abu-Ghannam, N., 2016, Identification and characterization of phenolic antioxidant compounds from brown Irish seaweed Himanthalia elongata using LC-DAD–ESI-MS/MS, Innov. Food Sci. Emerg. Technol., 37, 261–268.
Resende, D.I.S.P., Ferreira, M., Magalhães, C., Sousa Lobo, J.M., Sousa, E., and Almeida, I.F., 2021, Trends in the use of marine ingredients in anti-aging cosmetics, Algal Res., 55, .
Rodriguez-Jasso, R.M., Mussatto, S.I., Pastrana, L., Aguilar, C.N., and Teixeira, J.A., 2011, Microwave-assisted extraction of sulfated polysaccharides (fucoidan) from brown seaweed, Carbohydr. Polym., 86, 1137–1144.
Seth, K., Kumar, A., Rastogi, R.P., Meena, M., and Vinayak, V., 2021, Bioprospecting of fucoxanthin from diatoms—Challenges and perspectives, Algal Res.,.
Silva, J., Alves, C., Freitas, R., Martins, A., Pinteus, S., Ribeiro, J., Gaspar, H., Alfonso, A., and Pedrosa, R., 2019, Antioxidant and neuroprotective potential of the brown seaweed bifurcaria bifurcata in an in vitro Parkinson’s disease model, Mar. Drugs, 17, 1–17.
Stranska-Zachariasova, M., Kurniatanty, I., Gbelcova, H., Jiru, M., Rubert, J., Nindhia, T.G.T., D’Acunto, C.W., Sumarsono, S.H., Tan, M.I., Hajslova, J., and Ruml, T., 2017, Bioprospecting of Turbinaria Macroalgae as a Potential Source of Health Protective Compounds, Chem. Biodivers., 14, .
Di Valentin, M., Büchel, C., Giacometti, G.M., and Carbonera, D., 2012, Chlorophyll triplet quenching by fucoxanthin in the fucoxanthin-chlorophyll protein from the diatom Cyclotella meneghiniana, Biochem. Biophys. Res. Commun., 427, 637–641.
Vasanthi, C., Appa Rao, V., Narendra Babu, R., Sriram, P., and Karunakaran, R., 2020, In-vitro antioxidant activities of aqueous and alcoholic extracts of Sargassum species—Indian brown seaweed, J. Food Process. Preserv., 44, 1–9.
Veide Vilg, J. and Undeland, I., 2017, pH-driven solubilization and isoelectric precipitation of proteins from the brown seaweed Saccharina latissima—effects of osmotic shock, water volume and temperature, J. Appl. Phycol., 29, 585–593.
Wang, J., Ma, Y., Yang, J., Jin, L., Gao, Z., Xue, L., Hou, L., Sui, L., Liu, J., and Zou, X., 2019, Fucoxanthin inhibits tumour-related lymphangiogenesis and growth of breast cancer, J. Cell. Mol. Med., 23, 2219–2229.
Wang, L., Oh, J.Y., Kim, Y.S., Lee, H.G., Lee, J.S., and Jeon, Y.J., 2020, Anti-photoaging and anti-melanogenesis effects of fucoidan isolated from Hizikia fusiforme and its underlying mechanisms, Mar. Drugs, 18, 1–12.
Wang, X., Cui, Y., Qi, J., Zhu, M., Zhang, T., and ..., 2018, Fucoxanthin exerts cytoprotective effects against hydrogen peroxide-induced oxidative damage in L02 cells, BioMed Res. …,.
Xia, S., Wang, K., Wan, L., Li, A., Hu, Q., and Zhang, C., 2013, Production, characterization, and antioxidant activity of fucoxanthin from the marine diatom odontella aurita, Mar. Drugs, 11, 2667–2681.
Yang, G., Jin, L., Zheng, D., Tang, X., and Yang, J., 2019, Fucoxanthin Alleviates Oxidative Stress through,1–17.
Yang, H.-L., Lin, C.-P., Gowrisankar, Y.V., Huang, P.-J., Chang, W.-L., Shrestha, S., and Hseu, Y.-C., 2021, The anti-melanogenic effects of ellagic acid through induction of autophagy in melanocytes and suppression of UVA-activated α-MSH pathways via Nrf2 activation in keratinocytes., Biochem. Pharmacol., 185, 114454.
Zhang, R., Yuen, A.K.L., de Nys, R., Masters, A.F., and Maschmeyer, T., 2020, Step by step extraction of bio-actives from the brown seaweeds, Carpophyllum flexuosum, Carpophyllum plumosum, Ecklonia radiata and Undaria pinnatifida, Algal Res., 52, 102092.
Zhao, D., Kwon, S.H., Chun, Y.S., Gu, M.Y., and Yang, H.O., 2017, Anti-Neuroinflammatory Effects of Fucoxanthin via Inhibition of Akt/NF-κB and MAPKs/AP-1 Pathways and Activation of PKA/CREB Pathway in Lipopolysaccharide-Activated BV-2 Microglial Cells, Neurochem. Res., 42, 667–677.
Zhao, Xinjie, Gao, L., and Zhao, Xiangzhong, 2022, Purification of Fucoxanthin from of Fucoxanthin from, Molecules, 24, .
Published
2024-10-29
How to Cite
Setyowati, E. P., Wirasti, W., Murwanti, R., & Fakhrudin, N. (2024). Bioactivity of Fucoxanthin From Brown Seaweed as Antioxidant and Anti-melanogenesis: A Narrative Review. Indonesian Journal of Pharmacy. https://doi.org/10.22146/ijp.9344
Issue
Section
Review Article
