The Effectiveness of Tempuyung Leaves' Water Fraction for Inflammation Prevention of Wistar Rats in an Acute Gout Arthritis Model
Keywords:
gout, prevention, tempuyung leaf
Abstract
Gouty arthritis is inflammation of the joints that occurs in conditions of chronic hyperuricemia resulting in the deposition of monosodium urate crystals. The management of gout arthritis will emphasize both the acute and chronic phase and the initial drug options for gouty arthritis are non-steroidal anti-inflammatory drugs (NSAIDs), corticosteroids, and colchicine. However, administering chemical drugs can cause various risks and side effects, so alternative treatments are needed, one of which is using herbal medicine. Tempuyung (Sonchus arvensis) is a plant that is often found and easily cultivated in Indonesia, the water fraction of tempuyung leaves contains flavonoids, which can inhibit the pathogenesis of gout arthritis Therefore, this study examined the role of tempuyung (Sonchus arvensis) in preventing gouty arthritis by analyzing the effectiveness of tempuyung leaf fractions in inhibiting the inflammatory cascade. Both the quantitative and qualitative research were done. This research was carried out from March to December 2023 in the Animal House Laboratory, Basic Medical Chemistry, Medical Biotechnology, Faculty of Medicine, Sriwijaya University, Palembang, Special Laboratory for Anatomical Pathology, Barokah Palembang, Integrated Research and Testing Laboratory, Gadjah Mada University, Yogyakarta, and PT Laboratory. Garuda Malang Wing Mission. This research is an experimental study using experimental animals (in vivo) with a post-test control group design. Just as well as colchicine, the water component of tempuyung leaves can reduce inflammation in gouty arthritis. It is desired that more research on the toxicity test of tempuyung leaf water fractions can be conducted in the future to ascertain the safety of these fractions.
References
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Gürkan, A., Oğuz, M. M., Boduroğlu Cengiz, E., & Şenel, S. (2018). Dermatologic Manifestations of Colchicine Intoxication. Pediatric emergency care, 34(7), e131–e133. https://doi.org/10.1097/PEC.0000000000001530
Hasan F, A. Aziz S, Melati M. Perbedaan Waktu Panen Daun terhadap Produksi dan Kadar Flavonoid Tempuyung (Sonchus arvensis). Jurnal Hortikultura Indonesia. 2017;8(2):136–45.
Harahap N.I. Skrining Dan Karakterisasi Simplisia Daun Tempuyung (Sonchus Arvensis.L) Imelda Pekerja Indonesia. JIFI (Jurnal Ilmiah Farmasi Imelda). 2020;3(2):2655–3147.
Jayakumar S, Saraswathi I, Vijayakumar, Vijayaraghavan. Phytochemical Analysis Of Methanolic Extract Of Seeds Of Mucuna Pruriens By Gas Chromatography Mass Spectrometry. IJPSR. 2017;8(7):2916–21.
Kang, E. H., Park, E. H., Shin, A., Song, J. S., & Kim, S. C. (2021). Cardiovascular risk associated with allopurinol vs. benzbromarone in patients with gout. European heart journal, 42(44), 4578–4588. https://doi.org/10.1093/eurheartj/ehab619
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Khuluk, R. H., Yunita, A., Rohaeti, E., Syafitri, U. D., Linda, R., Lim, L. W., Takeuchi, T., & Rafi, M. (2021). An HPLC-dad method to quantify flavonoids in Sonchus arvensis and able to classify the plant parts and their geographical area through principal component analysis. MDPI. https://doi.org/10.3390/separations8020012
Kwak, J. H., Kim, Y., Staatz, C. E., & Baek, I. H. (2021). Oral bioavailability and pharmacokinetics of esculetin following intravenous and oral administration in rats. Xenobiotica; the fate of foreign compounds in biological systems, 51(7), 811–817. https://doi.org/10.1080/00498254.2021.1925774
Lee, Y. K., Lee, H., Kim, Y. N., Kang, J., Jeong, E. J., & Rho, J. R. (2023). Sesquiterpene Lactones with Anti-Inflammatory Activity from the Halophyte Sonchus brachyotus DC. Molecules (Basel, Switzerland), 28(4), 1518. https://doi.org/10.3390/molecules28041518
Li, Y., Wang, P., Yang, X., Wang, W., Zhang, J., He, Y., Zhang, W., Jing, T., Wang, B., & Lin, R. (2016). SIRT1 inhibits inflammatory response partly through regulation of NLRP3 inflammasome in vascular endothelial cells. Molecular immunology, 77, 148–156. https://doi.org/10.1016/j.molimm.2016.07.018
Liang, Y., Zhou, H. F., Tong, M., Chen, L., Ren, K., & Zhao, G. J. (2019). Colchicine inhibits endothelial inflammation via NLRP3/CRP pathway. International journal of cardiology, 294, 55. https://doi.org/10.1016/j.ijcard.2019.06.070
Liu, W., Zhang, L., Xu, H. J., Li, Y., Hu, C. M., Yang, J. Y., & Sun, M. Y. (2018). The Anti-Inflammatory Effects of Vitamin D in Tumorigenesis. International journal of molecular sciences, 19(9), 2736. https://doi.org/10.3390/ijms19092736
Manurung, H., Susanto, D., Kusumawati, E., Aryani, R., Nugroho, R. A., Kusuma, R., Rahmawati, Z., & Sari, R. D. (2022). Phytochemical, GC-MS analysis and antioxidant activities of leaf methanolic extract of Lai (Durio kutejensis), the endemic plant of Kalimantan, Indonesia. Biodiversitas, 23(11). https://doi.org/10.13057/biodiv/d231104
Mohammed, H. (2020). Phytochemistry and pharmacological effects of plants in genus Sonchus (asteraceae). Records of Pharmaceutical and Biomedical Sciences, 4(1), 40–50. https://doi.org/10.21608/rpbs.2019.18952.1046
Nuki G. (2008). Colchicine: its mechanism of action and efficacy in crystal-induced inflammation. Current rheumatology reports, 10(3), 218–227. https://doi.org/10.1007/s11926-008-0036-3
Otani, K., Watanabe, T., Shimada, S., Takeda, S., Itani, S., Higashimori, A., Nadatani, Y., Nagami, Y., Tanaka, F., Kamata, N., Yamagami, H., Tanigawa, T., Shiba, M., Tominaga, K., Fujiwara, Y., & Arakawa, T. (2016). Colchicine prevents NSAID-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Scientific reports, 6, 32587. https://doi.org/10.1038/srep32587
Paço, A., Brás, T., Santos, J. O., Sampaio, P., Gomes, A. C., & Duarte, M. F. (2022). Anti-Inflammatory and Immunoregulatory Action of Sesquiterpene Lactones. Molecules (Basel, Switzerland), 27(3), 1142. https://doi.org/10.3390/molecules2703114
Rafi, M., Suwartiny, N. L., & Rohaeti, E. (2022). Traditional Use, Phytochemical Composition, and Biological Activities of Sonchus arvensis. Indonesian Journal of Pharmacy, 540–553. https://doi.org/10.22146/ijp.3823
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Published
2025-01-30
How to Cite
Nita Parisa, Kamaluddin, M. T., Saleh, M. I., Sinaga, E., Partan, R. U., Irfannuddin, & Mangunsong, S. (2025). The Effectiveness of Tempuyung Leaves’ Water Fraction for Inflammation Prevention of Wistar Rats in an Acute Gout Arthritis Model . Indonesian Journal of Pharmacy. https://doi.org/10.22146/ijp.14504
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Section
Research Article
