Anredera cordifolia Extract in Reducing Immunoglobulin E Expression in Wistar Rats Allergic Model
Anredera cordifolia Extract in Reducing Immunoglobulin E
Keywords:
Anredera cordifolia, anti-inflammatory, nasal administration, toxicity
Abstract
Anredera cordifolia (AC), the binahong plant in Indonesia, has been extensively used in herbal medicine since ancient times. AC contains secondary metabolites, such as flavonoids, with anti-oxidative, anti-inflammatory, anti-mutagenic, and anti-carcinogenic properties. Many flavonoid compounds with anti-inflammatory activity can potentially treat nasal inflammation, such as allergic rhinitis. This study aims to determine whether there is a decrease in IgE expression after AC extract administration in the Wistar rats allergic model. The research was conducted on 36 Wistar rats classified into nine groups: control group (K1), negative control group (K2), positive control group (K3), treatment group with hydrogel intranasal AC extract of 2.5% (P1), 5% (P2), and 7.5% (P3), and treatment group with oral AC extract of 25 mg/200 g BW (P4), 50 mg/200 g BW (P5), and 75 mg/200 g BW (P6). Afterward, ELISA examined the expression of IgE. The t-test results for treatment groups applied with hydrogel intranasal AC extract of 2.5% revealed a significant difference in decreasing IgE levels. In conclusion, the finding supports that AC extract exerts its anti-allergy properties by suppressing IgE levels in the Wistar rats allergic model.
References
REFERENCES
Bahtiar, A., Utami, P. S. and Noor, M. R. (2021). The antioxidant effects of the ethanolic extract of binahong leaves unilateral ureteral obstruction rat model. Pharmacognosy Journal, 13(1), pp. 185–188. doi: 10.5530/pj.2021.13.26.
Bari, I. N., Kato-Noguchi, H., Iwasaki, A. and Suenaga, K. (2019). Allelopathic potency and an active substance from Anredera cordifolia (Tenore) steenis. Plants, 8(134). Doi:10.3390/plants8050134.
Chen, H. et al. (2021). Effects and mechanism of Chinese medicine Jiawei Yupingfeng in a mouse model of allergic rhinitis. Journal of Integrative Medicine, 19(4), pp. 354–361. doi: 10.1016/j.joim.2021.01.012.
Choi, S. et al. (2021). Anti-allergic effects of Asarum heterotropoides on an ovalbumin-induced allergic rhinitis murine model. Biomedicine and Pharmacotherapy, 141(July), p. 111944. doi: 10.1016/j.biopha.2021.111944.
Dubey, K. K., Vui, C. S. and Htay, M. N. N. (2019). Allergic Rhinitis: Diagnosis and Management Revisited. Asian Journal of Medical Principles and Clinical Practice, 2(3), pp. 1–9. Available at: http://www.sdiarticle4.com/review-history/53000.
Han, S., Sun, L., He, F. and Che, H. (2017). Anti-Allergic activity of glycyrrhizic acid on IgE-mediated allergic reaction by regulation of allergy-related immune cells. Scientific Reports, 7(1), pp. 1–9. doi: 10.1038/s41598-017-07833-1.
Hoang, M. P., Chitsuthipakorn, W. and Snidvongs, K. (2021). Herbal Medicines for Allergic Rhinitis: a Systematic Review and Meta-analysis. Current Allergy and Asthma Reports, 21(4). doi: 10.1007/s11882-021-00999-9.
Jafarinia, M. et al. (2020). Quercetin with the potential effect on allergic diseases. Allergy, Asthma and Clinical Immunology, 16(1), pp. 1–11. doi: 10.1186/s13223-020-00434-0.
Komnos, I. D., Michali, M. C., Asimakopoulos, A. D., Basiari, L. V. and Kastanioudakis, I. G. (2019). The Effect of Allergic Rhinitis on Quality of Life in Patients Suffering from the Disease: A Case Control Study. International Journal of Otolaryngology Head & Neck Surgery, 08(04), pp. 121–131. doi: 10.4236/ijohns.2019.84014.
Kotov, S., Gontova, T., Kononenko, N., Chernyavski, E. and Chikitkina, V. (2022). Phytochemical analysis and anti-allergic activity of a combined herbal medicine based on bur-marigold, calendula and hawthorn. Pharmacia, 69(1), pp. 237–247. doi: 10.3897/pharmacia.69.e77624.
Kow, A. S. F. et al. (2023). Clinacanthus nutans aqueous leaves extract exerts anti-allergic activity in preclinical anaphylactic models via alternative IgG pathway. Journal of Ethnopharmacology, 303(December 2022), p. 116003. doi: 10.1016/j.jep.2022.116003.
Leliqia, N. P. E., Sukandar, E. Y. and Fidrianny, I. (2017). Overview of efficacy, safety and phytochemical study of anredera cordifolia (Ten.) steenis. Pharmacologyonline, 1, pp. 124–131. Available at: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019683116&partnerID=40&md5=eeee51d3d778dbb0c7965103a51a7f04.
Licari, A., Castagnoli, R., Tosca, M. A., Marseglia, G. and Ciprandi, G. (2019). Personalized therapies for the treatment of allergic rhinitis. Expert Review of Precision Medicine and Drug Development, 4(5), pp. 275–281. doi: 10.1080/23808993.2019.1681896.
Locke, N. R., Royce, S. G., Wainewright, J. S., Samuel, C. S. and Tang, M. L. (2007). Comparison of airway remodeling in acute, subacute, and chronic models of allergic airways disease. American Journal of Respiratory Cell and Molecular Biology, 36(5), pp. 625–632. doi: 10.1165/rcmb.2006-0083OC.
Man, C. W., Leung, H. Y., Leong, P. K., Ming, Y. C. T. and Ko, K. M. (2020). Anti-Inflammatory Effects of a Cordyceps sinensis Allergic Rhinitis and Asthma. Molecules, 25, pp. 1–18.
Medeiros, K. C. P. et al. (2008). Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice. Journal of Ethnopharmacology, 119(1), pp. 41–46. doi: 10.1016/j.jep.2008.05.036.
Meltzer, E. O. (2001). Quality of life in adults and children with allergic rhinitis. Journal of Allergy and Clinical Immunology, 108(1 SUPPL.), pp. 45–53. doi: 10.1067/mai.2001.115566.
Passali, D. et al. (2018). The International Study of the Allergic Rhinitis Survey: outcomes from 4 geographical regions. Asia Pacific Allergy, 8(1), pp. 1–15. doi: 10.5415/apallergy.2018.8.e7.
Rahim, N. A. et al. (2021). Anti-Allergic Rhinitis Effects of Medicinal Plants and Their Bioactive Metabolites via Suppression of the Immune System: A Mechanistic Review. Frontiers in Pharmacology, 12(April), pp. 1–19. doi: 10.3389/fphar.2021.660083.
Rakha, A. et al. (2022). Anti-inflammatory and anti-allergic potential of dietary flavonoids: A review. Biomedicine and Pharmacotherapy, 156, p. 113945. doi: 10.1016/j.biopha.2022.113945.
Rosário, C. S., Murrieta-Aguttes, M. and Rosario, N. A. (2021). Allergic rhinitis: Impact on quality of life of adolescents. European Annals of Allergy and Clinical Immunology, 53(6), pp. 247–251. doi: 10.23822/EURANNACI.1764-1489.176.
Salim, A. et al. (2021). Phytochemical Screening and Therapeutic Effects of Binahong (Anredera cordifolia (Ten.) Steenis) Leaves. Indonesian Journal of Life Sciences | ISSN: 2656-0682 (online), 3(2), pp. 43–55. doi: 10.54250/ijls.v3i2.125.
Shams, M. H. et al. (2021). Anti-allergic effects of vitamin E in allergic diseases: An updated review. International Immunopharmacology, 90(September 2020), p. 107196. doi: 10.1016/j.intimp.2020.107196.
Shao, Y. Y. et al. (2017). The anti-allergic rhinitis effect of traditional Chinese medicine of Shenqi by regulating mast cell degranulation and Th1/Th2 cytokine balance. Molecules, 22(3), pp. 1–11. doi: 10.3390/molecules22030504.
Sim, L. Y., Rani, N. Z. A. and Husain, K. (2019). Lamiaceae: An insight on their anti-allergic potential and its mechanisms of action. Frontiers in Pharmacology, 10(JUN). doi: 10.3389/fphar.2019.00677.
Tedjakusuma, F. and Lo, D. (2022). Functional properties of Anredera cordifolia (Ten.) Steenis: A review. IOP Conference Series: Earth and Environmental Science, 998(1). doi: 10.1088/1755-1315/998/1/012051.
Wise, S. K. et al. (2018). International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis. Int Forum Allergy Rhinol., 8(2), pp. 108–352. doi: Doi:10.1002/alr.22073.
Zoabi, Y., Levi-Schaffer, F. and Eliashar, R. (2022). Allergic Rhinitis: Pathophysiology and Treatment Focusing on Mast Cells. Biomedicines, 10, p. 2486. doi: 10.3390/biomedicines10102486.
Bahtiar, A., Utami, P. S. and Noor, M. R. (2021). The antioxidant effects of the ethanolic extract of binahong leaves unilateral ureteral obstruction rat model. Pharmacognosy Journal, 13(1), pp. 185–188. doi: 10.5530/pj.2021.13.26.
Bari, I. N., Kato-Noguchi, H., Iwasaki, A. and Suenaga, K. (2019). Allelopathic potency and an active substance from Anredera cordifolia (Tenore) steenis. Plants, 8(134). Doi:10.3390/plants8050134.
Chen, H. et al. (2021). Effects and mechanism of Chinese medicine Jiawei Yupingfeng in a mouse model of allergic rhinitis. Journal of Integrative Medicine, 19(4), pp. 354–361. doi: 10.1016/j.joim.2021.01.012.
Choi, S. et al. (2021). Anti-allergic effects of Asarum heterotropoides on an ovalbumin-induced allergic rhinitis murine model. Biomedicine and Pharmacotherapy, 141(July), p. 111944. doi: 10.1016/j.biopha.2021.111944.
Dubey, K. K., Vui, C. S. and Htay, M. N. N. (2019). Allergic Rhinitis: Diagnosis and Management Revisited. Asian Journal of Medical Principles and Clinical Practice, 2(3), pp. 1–9. Available at: http://www.sdiarticle4.com/review-history/53000.
Han, S., Sun, L., He, F. and Che, H. (2017). Anti-Allergic activity of glycyrrhizic acid on IgE-mediated allergic reaction by regulation of allergy-related immune cells. Scientific Reports, 7(1), pp. 1–9. doi: 10.1038/s41598-017-07833-1.
Hoang, M. P., Chitsuthipakorn, W. and Snidvongs, K. (2021). Herbal Medicines for Allergic Rhinitis: a Systematic Review and Meta-analysis. Current Allergy and Asthma Reports, 21(4). doi: 10.1007/s11882-021-00999-9.
Jafarinia, M. et al. (2020). Quercetin with the potential effect on allergic diseases. Allergy, Asthma and Clinical Immunology, 16(1), pp. 1–11. doi: 10.1186/s13223-020-00434-0.
Komnos, I. D., Michali, M. C., Asimakopoulos, A. D., Basiari, L. V. and Kastanioudakis, I. G. (2019). The Effect of Allergic Rhinitis on Quality of Life in Patients Suffering from the Disease: A Case Control Study. International Journal of Otolaryngology Head & Neck Surgery, 08(04), pp. 121–131. doi: 10.4236/ijohns.2019.84014.
Kotov, S., Gontova, T., Kononenko, N., Chernyavski, E. and Chikitkina, V. (2022). Phytochemical analysis and anti-allergic activity of a combined herbal medicine based on bur-marigold, calendula and hawthorn. Pharmacia, 69(1), pp. 237–247. doi: 10.3897/pharmacia.69.e77624.
Kow, A. S. F. et al. (2023). Clinacanthus nutans aqueous leaves extract exerts anti-allergic activity in preclinical anaphylactic models via alternative IgG pathway. Journal of Ethnopharmacology, 303(December 2022), p. 116003. doi: 10.1016/j.jep.2022.116003.
Leliqia, N. P. E., Sukandar, E. Y. and Fidrianny, I. (2017). Overview of efficacy, safety and phytochemical study of anredera cordifolia (Ten.) steenis. Pharmacologyonline, 1, pp. 124–131. Available at: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85019683116&partnerID=40&md5=eeee51d3d778dbb0c7965103a51a7f04.
Licari, A., Castagnoli, R., Tosca, M. A., Marseglia, G. and Ciprandi, G. (2019). Personalized therapies for the treatment of allergic rhinitis. Expert Review of Precision Medicine and Drug Development, 4(5), pp. 275–281. doi: 10.1080/23808993.2019.1681896.
Locke, N. R., Royce, S. G., Wainewright, J. S., Samuel, C. S. and Tang, M. L. (2007). Comparison of airway remodeling in acute, subacute, and chronic models of allergic airways disease. American Journal of Respiratory Cell and Molecular Biology, 36(5), pp. 625–632. doi: 10.1165/rcmb.2006-0083OC.
Man, C. W., Leung, H. Y., Leong, P. K., Ming, Y. C. T. and Ko, K. M. (2020). Anti-Inflammatory Effects of a Cordyceps sinensis Allergic Rhinitis and Asthma. Molecules, 25, pp. 1–18.
Medeiros, K. C. P. et al. (2008). Anti-allergic effect of bee pollen phenolic extract and myricetin in ovalbumin-sensitized mice. Journal of Ethnopharmacology, 119(1), pp. 41–46. doi: 10.1016/j.jep.2008.05.036.
Meltzer, E. O. (2001). Quality of life in adults and children with allergic rhinitis. Journal of Allergy and Clinical Immunology, 108(1 SUPPL.), pp. 45–53. doi: 10.1067/mai.2001.115566.
Passali, D. et al. (2018). The International Study of the Allergic Rhinitis Survey: outcomes from 4 geographical regions. Asia Pacific Allergy, 8(1), pp. 1–15. doi: 10.5415/apallergy.2018.8.e7.
Rahim, N. A. et al. (2021). Anti-Allergic Rhinitis Effects of Medicinal Plants and Their Bioactive Metabolites via Suppression of the Immune System: A Mechanistic Review. Frontiers in Pharmacology, 12(April), pp. 1–19. doi: 10.3389/fphar.2021.660083.
Rakha, A. et al. (2022). Anti-inflammatory and anti-allergic potential of dietary flavonoids: A review. Biomedicine and Pharmacotherapy, 156, p. 113945. doi: 10.1016/j.biopha.2022.113945.
Rosário, C. S., Murrieta-Aguttes, M. and Rosario, N. A. (2021). Allergic rhinitis: Impact on quality of life of adolescents. European Annals of Allergy and Clinical Immunology, 53(6), pp. 247–251. doi: 10.23822/EURANNACI.1764-1489.176.
Salim, A. et al. (2021). Phytochemical Screening and Therapeutic Effects of Binahong (Anredera cordifolia (Ten.) Steenis) Leaves. Indonesian Journal of Life Sciences | ISSN: 2656-0682 (online), 3(2), pp. 43–55. doi: 10.54250/ijls.v3i2.125.
Shams, M. H. et al. (2021). Anti-allergic effects of vitamin E in allergic diseases: An updated review. International Immunopharmacology, 90(September 2020), p. 107196. doi: 10.1016/j.intimp.2020.107196.
Shao, Y. Y. et al. (2017). The anti-allergic rhinitis effect of traditional Chinese medicine of Shenqi by regulating mast cell degranulation and Th1/Th2 cytokine balance. Molecules, 22(3), pp. 1–11. doi: 10.3390/molecules22030504.
Sim, L. Y., Rani, N. Z. A. and Husain, K. (2019). Lamiaceae: An insight on their anti-allergic potential and its mechanisms of action. Frontiers in Pharmacology, 10(JUN). doi: 10.3389/fphar.2019.00677.
Tedjakusuma, F. and Lo, D. (2022). Functional properties of Anredera cordifolia (Ten.) Steenis: A review. IOP Conference Series: Earth and Environmental Science, 998(1). doi: 10.1088/1755-1315/998/1/012051.
Wise, S. K. et al. (2018). International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis. Int Forum Allergy Rhinol., 8(2), pp. 108–352. doi: Doi:10.1002/alr.22073.
Zoabi, Y., Levi-Schaffer, F. and Eliashar, R. (2022). Allergic Rhinitis: Pathophysiology and Treatment Focusing on Mast Cells. Biomedicines, 10, p. 2486. doi: 10.3390/biomedicines10102486.
Published
2024-11-13
How to Cite
Widuri, A., Rianto, B. U. D., Indrawati, L. P. L., Heriyanto, D. S., & Febriansah, R. (2024). Anredera cordifolia Extract in Reducing Immunoglobulin E Expression in Wistar Rats Allergic Model. Indonesian Journal of Pharmacy. https://doi.org/10.22146/ijp.11055
Issue
Section
Research Article
