* Corresponding Author
Effect of advanced platelet-rich fibrin applications on periodontal regeneration in infrabony pocket treatment
https://doi.org/10.22146/majkedgiind.37414 Christopher Imantaka Suwondo(1*), Dahlia Herawati(2), Sudibyo Sudibyo(3)
(1) Dentes Dental Clinic, Pamecutan Klod, Denpasar, Bali
(2) Department of Periodontia, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta
(3) Department of Periodontia, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author
Abstract
One of the regenerative periodontal treatments for infrabony pocket is open flap debridement (OFD) with the addition of growth factor derived from platelet concentrate. Advanced platelet-rich fibrin (A-PRF) is a further development of plateletrich fibrin (PRF) with a lower centrifugation speed (1,500 rpm, 14 minutes). The purpose of this study was to examine the differences in periodontal tissue regeneration after the application of A-PRF and PRF in the treatment of infrabony pockets evaluated from probing depth (PD), relative attachment loss (RAL), and alveolar bone height. The samples were taken from 20 infrabony pockets divided into 2 groups: 10 subjects were treated with OFD+A-PRF and OFD+PRF on the remaining subjects. Probing depth (PD) and relative attachment loss (RAL) measurement were performed on days 0, 30, and 90. Bone height measurements were performed using CBCT X-rays on days 0 and 90. The results showed that PD and RAL reduction in the group of OFD+A-PRF was significantly greater than that in the OFD+PRF group. Bone height reduction in both groups showed no difference. The conclusion obtained from this study is A-PRF application enhances periodontal tissue regeneration by generating greater probing depth and relative attachment loss reduction compared to
PRF, as well as an increase in bone height similar to in the treatment of infrabony pockets.
Keywords
Full Text:
PDF-6References
1. Mani R, Mahantesha S, Nandini TK, Lavanya R. Growth factors in periodontal regeneration.
Journal of Advanced Oral Research. 2015; 5(2): 1-5.
2. Newman MG, Takei HH, Klokkevold PR. Carranza’s Clinical Periodontology 11th Edition. Missouri: Elsevier; 2012.
3. Bosshardt DD. The Periodontal pocket pathogenesis, histopathology, and consequences. Periodontology 2000. 2018; 76(1): 43-50.
4. Pradeep AR, Kanoriya D, Singhal S, Garg V, Guruprasad CN. Synergistic approach using platelet rich fibrin and 1% alendronate for intrabony defect treatment in chronic periodontitis: a randomized clinical trial. Journal of Periodontology. 2016; 87(12): 1427-1435.
5. Heitz-Mayfield LJA, Lang NP. Surgical and nonsurgical periodontal therapy learned and
unlearned concepts. Periodontology 2000. 2013; 62: 218-231.
6. Martande SS, Kumari M, Pradeep AR, Singh SP, Suke DK, Guruprasad CN. Platelet rich
fibrin combined with 1.2% atorvastatin for treatment of intrabony defects in chronic periodontitis: a randomized controlled clinical trial. Journal of Periodontology. 2016; 87(9):
1039-1046.
7. Suchetha A, Lakshmi P, Bhat D, Mundinamane DB, Soorya KV, Bharwani GA. Platelet
concentration in platelet concentrates and periodontal regeneration-unscrambling the
ambiguity. Contemporary Clinical Dentistry. 2015; 6: 510-516.
8. Reynolds MA, Kao RT, Nares S, Camargo PM, Caton JG, Clem DS, Fiorellini JP,
Geisinger ML, Mills MP, Nevins ML, Rosen PS. Periodontal Regeneration - Intrabony
Defects: Practical Applications From the AAP Regeneration Workshop. Clinical Advances in
Periodontics. 2015; 5(1): 21-29.
9. Hagi TT, Laugisch O, Ivanovic A, Sculean A. Regenerative periodontal therapy. Quintessence International. 2014; 45(3): 185-192.
10. Chadwick JK, Mills MP, Mealey BL. Clinical and radiographic evaluation of demineralized
freeze-dried bone allograft versus platelet-rich fibrin for the treatment of periodontal intrabony
defects in humans. Journal of Periodontology. 2016; 87(11): 1253-1260.
11. Crespi R, Cappare P, Gherlone E. Magnesium- Enriched hydroxyapatite compared to calcium sulfate in the healing of human extraction sockets: radiographic and histomorphometric evaluation at 3 months. Journal of Periodontology. 2009; 80(2): 210-218.
12. Cortellini P, Tonneti MS. Clinical concepts for regenerative therapy in intrabony defects.
Periodontology 2000. 2015; 68: 282-307.
13. Illueca FMA, Vera PB, Cabanilles PG, Fernandez VF, Loscos FJG. Periodontal regeneration in clinical practice. Med Oral Patol Oral Cir Bucal. 2006; 11: 382-392.
14. Ivanovski S. Periodontal regeneration. Australian Dental Journal. 2009; 54(1): 118-128.
15. Kobayashi E, Fluckiger L, Fujioka-Kobayashi M, Sawada K, Sculean A, Schaller B, Miron RJ. Comparative release of growth factors from PRP, PRF, and Advanced-PRF. Clinical Oral Investigations. 2016; 20(9): 2353-2360.
16. Fujioka-Kobayashi M, Miron RJ, Hernandez M, Kandalam U, Zhang Y, Choukroun J. Optimized platelet rich fibrin with the low speed concept: growth factor release, biocompatibility and cellular response. Journal of Periodontology. 2017; 88(1): 112-121.
17. Ehrenfest DMD, Corso MD, Diss A, Mouhyi J, Charrier JB. Three-Dimensional architecture
and cell composition of a choukroun’s plateletrich fibrin clot and membrane. Journal of Periodontology. 2010; 81(4): 546-555.
18. Ehrenfest DMD, De Peppo GM, Doglioli P, Sammartino G. Slow release of growth factors
and thrombospondin-1 in choukroun’s plateletrich fibrin (PRF): a gold standard to achieve for
all surgical platelet concentrates technologies. Growth Factors. 2009; 27(1): 63-69.
19. Toit JD, Gluckman H, Salama M. Platelet- Rich Fibrin (PRF): A Growth Factor-Rich Biomaterial. Part 1 - the Platelet Concentrates Milieu & Review of the Literature. International
Dentistry - African Edition. 2015; 5(5): 62-70.
20. Chandran P, Sivadas A. Platelet-Rich Fibrin: its role in periodontal regeneration. The
Saudi Journal for Dental Research. 2014; 5: 117-122.
21. Christgau M, Moder D, Hiller KA, Dada A, Schimtz G, Schmalz G. Growth factors and
cytokines in autologous platelet concentrate and their correlation to periodontal regeneration
outcomes. Journal of Clinical Periodontology. 2006; 33: 837-845.
22. Pradeep AR, Rao NS, Agarwal E, Bajaj P. Comparative evaluation of autologous
platelet-rich fibrin and platelet-rich plasma in the treatment of three-wall inrabony defects in
chronic periodontitis: a rancomized controlled clinical trial. Journal of Periodontology. 2012;
93(12): 1499-1507.
23. Ghanaati S, Booms P, Orlowska A, Kubesch A, Lorenz J, Rutkowski J, Landes C, Sader R, Kirkpatrick C, Choukroun J. Advanced Platelet-Rich Fibrin (A-PRF) - a new concept
for cell-based tissue engineering by means of inflammatory cells. Journal of Oral
Implantology. 2014; 40: 679-689.
24. Raja S, Byakod G, Pudakalkatti P. Growth factors in periodontal regeneration. International Journal of Dental Hygiene. 2009; 7: 82-89.
25. Pisoschi C, Stanciulescu C, Banita M. Growth factors and connective tissuehomeostasis
in periodontal disease, pathogenesis and treatment of periodontitis. Prof. Nurcan
Buduneli(Ed.); 2012. ISBN: 978-953-307-924-0. InTech, Available:from:http://www.intechopen.com/books/pathogenesis-andtreatment-ofperiodontitis/
growth-factors-and-connectivetissue-homeostasis-in-periodontal-disease
26. Prabhu P, Julius A, Elumalai M, Prabhu MN. Woung healing in periodontics. Biosciences Biotechnology Research Asia. 2014; 11(2): 791-795.
27. Chang YC, Wu KC, Zhao JH. Clinical application of platelet-rich fibrin as the sole
grafting material in periodontal intrabony defects. Journal of Dental Sciences. 2011; 6: 181-188.
28. Titirinli K, Tekin U, Atil F, Onder E, Senguven B, Ozgul O, Kocyigit ID. Evaluation of advanced platelet rich fibrin (A-PRF) on Bone healing is it better than old version a histological animal study. Journal of Biomaterials and Tissue Engineering. 2017; 7(6): 478-483.
29. Yun YR, Jang JH, Jeon E, Kang W, Lee S, Won JE, Kim HW, Wall I. Administration of growth
factors for bone regeneration. Regenerative Medicine. 2012; 7(3): 369-385.
30. Devescovi V, Leonardi E, Ciapetti G, Cenni E. Growth factors in bone repair. Chir Organi
Mov. 2008; 92: 161-168.
DOI: https://doi.org/10.22146/majkedgiind.37414
Article Metrics
Abstract views : 5080
| 
views : 18067
Refbacks
- There are currently no refbacks.
Copyright (c) 2018 Majalah Kedokteran Gigi Indonesia
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.