Analyzing the Potential of Herbal Plant Research for Alzheimer's Disease in Diabetes: A Bibliometric Approach

https://doi.org/10.22146/farmaseutik.v20i3.97209

Ahmad Marzuki(1), Almira Rahmayani(2), Muhammad Khafi(3), Triana Hertiani(4*), Retno Murwanti(5)

(1) Faculty of Pharmacy, Universitas Gadjah Mada Medical Laboratory Technology Faculty, Health Polytechnic Ministry of Health Maluku
(2) Faculty of Pharmacy, Universitas Gadjah Mada
(3) Faculty of Pharmacy, Universitas Gadjah Mada
(4) Faculty of Pharmacy, Universitas Gadjah Mada
(5) Faculty of Pharmacy, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Alzheimer’s disease is a progressive neurologic dementia disorder and the fifth leading cause of death among elderly individuals. Its pathogenesis is closely linked to diabetes-induced brain insulin resistance, which accelerates beta-amyloid accumulation, exacerbating disease severity. This condition significantly impacts quality of life and healthcare costs, necessitating effective treatment strategies. Medicinal plants offer a promising avenue, with bibliometric analysis identifying trending active compounds for potential development as therapies for diabetic Alzheimer’s. This study analyzed 200 articles from the Scopus database, employing Scopus and VOSviewer 1.6.20 to visualize bibliometric trends by publication, country/territory, subject area, and keyword co-occurrence. Results indicate a recent decline in research activity, with China leading in publications across pharmacology, medicine, and biochemistry. Notably, flavonoids like “quercetin,” “kaempferol,” and “gallic acid” emerged as prominent topics.

Keywords: Alzheimer’s diabetes, Bibliometrics, Herbal medicine, Extracts


Keywords


Alzheimer’s diabetes, Bibliometrics, Herbal medicine, Extracts

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References

Adem, M. A., Decourt, B., & Sabbagh, M. N. (2024). Pharmacological Approaches Using Diabetic Drugs Repurposed for Alzheimer’s Disease. Biomedicines, 12(1), Article 1. https://doi.org/10.3390/biomedicines12010099

Astuti, E., Raharjo, T. J., Manalu, P. B., Putra, I. S., Waskitha, S. S., & Solin, J. (2021). Synthesis, Molecular Docking, and Evaluation of Some New Curcumin Analogs as Antimalarial Agents. Indonesian Journal of Chemistry, 21(2), Article 2. https://doi.org/10.22146/ijc.57646

Bai, X., Zhao, X., Liu, K., Yang, X., He, Q., Gao, Y., Li, W., & Han, W. (2024). Mulberry Leaf Compounds and Gut Microbiota in Alzheimer’s Disease and Diabetes: A Study Using Network Pharmacology, Molecular Dynamics Simulation, and Cellular Assays. International Journal of Molecular Sciences, 25(7). Scopus. https://doi.org/10.3390/ijms25074062

Chatterjee, S., & Mudher, A. (2018). Alzheimer’s Disease and Type 2 Diabetes: A Critical Assessment of the Shared Pathological Traits. Frontiers in Neuroscience, 12. https://doi.org/10.3389/fnins.2018.00383

Fan, C., Sun, X., Wang, X., & Yu, H. (2023). Therapeutic potential of the chemical composition of Dendrobium nobile Lindl. Frontiers in Pharmacology, 14. Scopus. https://doi.org/10.3389/fphar.2023.1163830

Guven, L., Erturk, A., Koca, M., & Gulcin, I. (2023). Phenolic Compounds of Phlomis tuberosa by LC–MS/MS-Determination of Antioxidant Activity, Molecular Docking, and Enzyme Inhibition Profiles. ChemistrySelect, 8(48). Scopus. https://doi.org/10.1002/slct.202303101

Güven, L., Ertürk, A., Yılmaz, M. A., Alwasel, S., & Gülçin, İ. (2024). Alchemilla pseudocartalinica Juz: Phytochemical Screening by UPLC-MS/MS, Molecular Docking, Anti-oxidant, Anti-diabetic, Anti-glaucoma, and Anti-Alzheimer Effects. Records of Natural Products, 18(2), 251–272. Scopus. https://doi.org/10.25135/rnp.448.2312.2993

Hamzé, R., Delangre, E., Tolu, S., Moreau, M., Janel, N., Bailbé, D., & Movassat, J. (2022). Type 2 Diabetes Mellitus and Alzheimer’s Disease: Shared Molecular Mechanisms and Potential Common Therapeutic Targets. International Journal of Molecular Sciences, 23(23), 15287. https://doi.org/10.3390/ijms232315287

Jallow, A. W., Nguyen, D. P. Q., Sanotra, M. R., Hsu, C.-H., Lin, Y.-F., & Lin, Y.-F. (2024). A comprehensive bibliometric analysis of global research on the role of acrolein in Alzheimer’s disease pathogenesis: Involvement of amyloid-beta. Frontiers in Aging Neuroscience, 16. https://doi.org/10.3389/fnagi.2024.1378260

John, O. O., Amarachi, I. S., Chinazom, A. P., Adaeze, E., Kale, M. B., Umare, M. D., & Upaganlawar, A. B. (2022). Phytotherapy: A promising approach for the treatment of Alzheimer’s disease. Pharmacological Research - Modern Chinese Medicine, 2, 100030. https://doi.org/10.1016/j.prmcm.2021.100030

Kokol, P., Blažun Vošner, H., & Završnik, J. (2021). Application of bibliometrics in medicine: A historical bibliometrics analysis. Health Information & Libraries Journal, 38(2), 125–138. https://doi.org/10.1111/hir.12295

Lee, H. J., Seo, H. I., Cha, H. Y., Yang, Y. J., Kwon, S. H., & Yang, S. J. (2018). Diabetes and Alzheimer’s Disease: Mechanisms and Nutritional Aspects. Clinical Nutrition Research, 7(4), 229–240. https://doi.org/10.7762/cnr.2018.7.4.229

Liu, Y., Wang, R., Hu, X., Yu, C., Wang, Z., Zhang, L., Liu, S., & Li, C. (2024). Optimization of ultrasonic extraction of bioactive components from Alpiniae oxyphyllae Fructus using response surface methodology. Journal of Applied Research on Medicinal and Aromatic Plants, 41. Scopus. https://doi.org/10.1016/j.jarmap.2024.100557

Meng, X., Cui, W., Liang, Q., Zhang, B., & Wei, Y. (2024). Trends and hotspots in tea and Alzheimer’s disease research from 2014 to 2023: A bibliometric and visual analysis. Heliyon, 10(9), e30063. https://doi.org/10.1016/j.heliyon.2024.e30063

Momina, S. S., & Gandla, K. (2023). A Flavonoid-rich Fraction of Alternanthera pungens Ameliorates Hyperglycaemia -mediated Memory Dysfunction in Diabetic Rats. International Journal of Pharmaceutical Quality Assurance, 14(4), 1075–1089. Scopus. https://doi.org/10.25258/ijpqa.14.4.41

Muniroh, M., Nindita, Y., Karlowee, V., Purwoko, Y., Rahmah, N. D., Widyowati, R., & Suryono, S. (2021). Effect of garcinia mangostana pericarp extract on glial nf-κb levels and expression of serum inflammation markers in an obese-type 2 diabetes mellitus animal model. Biomedical Reports, 15(1). Scopus. https://doi.org/10.3892/br.2021.1439

Musa, H. H., Musa, T. H., Oderinde, O., Musa, I. H., Shonekan, O. O., Akintunde, T. Y., & Onasanya, A. K. (2023). Traditional herbal medicine: Overview of research indexed in the scopus database. Advances in Traditional Medicine, 23(4), 1173–1183. https://doi.org/10.1007/s13596-022-00670-2

Ntemafack, A., Ayoub, M., Hassan, Q. P., & Gandhi, S. G. (2023). A systematic review of pharmacological potential of phytochemicals from Rumex abyssinicus Jacq. South African Journal of Botany, 154, 11–25. Scopus. https://doi.org/10.1016/j.sajb.2023.01.013

Pramesthi, A. D. E. D., Lukitaningsih, E., & Nugroho, A. E. (2022). Potential Pharmacokinetics and Pharmacodynamics (PK-PD) Drug-Herbs Interactions (DHI) from Metformin and Traditional Medicines: A Literature Review. Pharmacognosy Journal, 14(1), 235–244. Scopus. https://doi.org/10.5530/pj.2022.14.29

Türkan, F., Atalar, M. N., Aras, A., Gülçin, İ., & Bursal, E. (2020). ICP-MS and HPLC analyses, enzyme inhibition and antioxidant potential of Achillea schischkinii Sosn. Bioorganic Chemistry, 94. Scopus. https://doi.org/10.1016/j.bioorg.2019.103333

Verma, S., & Singh, S. P. (2008). Current and future status of herbal medicine. Veterinary World, 2, 347. https://doi.org/10.5455/vetworld.2008.347-350

Wu, L., Chen, W., & Wang, Z. (2021). Traditional Indian medicine in China: The status quo of recognition, development and research. Journal of Ethnopharmacology, 279, 114317. https://doi.org/10.1016/j.jep.2021.114317

Yeniçeri, E., Altay, A., Koksal, E., Altın, S., Taslimi, P., Yılmaz, M. A., Cakir, O., Tarhan, A., & Kandemir, A. (2024). Phytochemical profile by LC-MS/MS analysis and evaluation of antioxidant, antidiabetic, anti-Alzheimer, and anticancer activity of Onobrychis argyrea leaf extracts. European Journal of Integrative Medicine, 66. Scopus. https://doi.org/10.1016/j.eujim.2024.102337



DOI: https://doi.org/10.22146/farmaseutik.v20i3.97209

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