Gambaran Tingkat Pengetahuan pada Pasien yang Mendapatkan Terapi Warfarin

Lina Wati Lubis; Fita Rahmawati; I Dewa Putu Pramantara

doi:10.22146/farmaseutik.v18i4.66925

Gambaran Tingkat Pengetahuan pada Pasien yang Mendapatkan Terapi Warfarin

https://doi.org/10.22146/farmaseutik.v18i4.66925

Lina Wati Lubis⁽¹⁾, Fita Rahmawati^(2*), I Dewa Putu Pramantara⁽³⁾

(1) Universitas Gadjah Mada
(2) Universitas Gadjah Mada
(3) RSUP dr. Sardjito
(*) Corresponding Author

Abstract

Keberhasilan penggunaan warfarin yang aman dan efektif dapat dicapai melalui pemberian informasi dan edukasi yang relevan sesuai dengan kebutuhan pasien. Informasi mengenai sejauh mana pemahaman pasien terhadap obat warfarin sangat diperlukan. Penelitian bertujuan mengidentifikasi tingkat pengetahuan pasien mengenai penggunaan obat antikoagulan warfarin. Penelitian ini merupakan studi prospektif cross-sectional yang melibatkan 83 pasien yang mendapatkan terapi warfarin di dua instalasi rawat jalan rumah sakit pemerintah. Modifikasi Oral Anticoagulant Knowledge (MOAK) yang telah reliabel dan valid digunakan untuk menilai pengetahuan pasien tentang warfarin. Hasil penelitian menunjukkan tingkat pengetahuan pasien tergolong rendah dengan rerata skor pengetahuan 28,5% (SD±19,07). Sejumlah 11 responden (13,3%) memiliki kategori rendah (rerata skor MOAK > 50%), 70 responden (84,3%) memiliki pengetahuan kategori sedang (rerata skor MOAK 50%-30%), dan 2 responden (2,4%) memiliki kategori baik (rerata skor MOAK < 30%). Pengetahuan yang paling dikuasai oleh pasien adalah pengetahuan mengenai indikasi obat warfarin (82,85%) sementara itu pengetahuan terendah adalah pada pertanyaan mengenai interaksi obat warfarin dengan vitamin K (12,85%) dan cara melakukan diet selama mengkonsumsi warfarin (12,85%). Mayoritas pengetahuan pasien tergolong masih rendah sehingga diperlukan peran yang lebih aktif dari tenaga kesehatan khususnya farmasi dalam memberikan informasi dan edukasi yang lebih berfokus kepada kesenjangan pengetahuan terbanyak yang dialami oleh pasien.

Keywords

antikoagulan; pengetahuan; warfarin

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References

Alphonsa, A. dkk. (2015) ‘Knowledge Regarding Oral Anticoagulation Therapy among Patients with Stroke and Those at High Risk of Thromboembolic Events’, Journal of Stroke and Cerebrovascular Diseases, 24(3), pp. 668–672. doi: 10.1016/j.jstrokecerebrovasdis.2014.11.007. Ansell, J., Hirsh, J. and Poller, L. (2004) ‘The Pharmacology and Management of the Vitamin K Antagonists The Seventh ACCP Conference on Antithrombotic and Thrombolytic’, CHESTLEG, 126(3), pp. 204S-233S. doi: 10.1378/chest.126.3. Chang, C. H. et al. (2014) ‘A practical approach to minimize the interaction of dietary vitamin K with warfarin’, Journal of Clinical Pharmacy and Therapeutics, 39(1), pp. 56–60. doi: 10.1111/jcpt.12104. Chenot, J. et al. (2014) ‘Safety relevant knowledge of orally anticoagulated patients without self-monitoring : a baseline survey in primary care’, pp. 1–8. Hernández Madrid, A. et al. (2016) ‘Differences in attitude, education, and knowledge about oral anticoagulation therapy among patients with atrial fibrillation in Europe: Result of a self-assessment patient survey conducted by the European Heart Rhythm Association’, Europace, 18(3), pp. 463–467. doi: 10.1093/europace/euv448. Jani, Y. H., Hirani, B. and Livingstone, C. (2021) ‘Evaluation of patients’ knowledge about oral anticoagulant medicines and use of alert cards by community pharmacists’, International Journal of Clinical Pharmacy, 43(1), pp. 203–211. doi: 10.1007/s11096-020-01134-w. Kagansky, N. et al. (2004) ‘Safety of anticoagulation therapy in well-informed older patients’, Archives of Internal Medicine, 164(18), pp. 2044–2050. doi: 10.1001/archinte.164.18.2044. Khatib, R. et al. (2019) ‘Vitamin K for reversal of excessive Vitamin K antagonist anticoagulation: A systematic review and meta-analysis’, Blood Advances, 3(5), pp. 789–796. doi: 10.1182/bloodadvances.2018025163. Li, X. et al. (2018) ‘Assessment of patients’ Warfarin Knowledge and Anticoagulation Control at a Joint Physician-and Pharmacist-Managed Clinic in China’, Patient Preference and Adherence, 12, pp. 783–791. doi: 10.2147/PPA.S156734. Lurie, Y. et al. (2010) ‘Warfarin and vitamin K intake in the era of pharmacogenetics’, British Journal of Clinical Pharmacology, 70(2), pp. 164–170. doi: 10.1111/j.1365-2125.2010.03672.x. Matalqah, L. et al. (2013) ‘Relationship between patients’ warfarin knowledge and anticoagulation control: results of a validated tool in Malaysia. Affiliation’, J Pharm Biomed Sci, 30(30), pp. 967–974. Mavri, A. et al. (2015) ‘New educational approach for patients on warfarin improves knowledge and therapy control’, Wiener Klinische Wochenschrift, 127(11–12), pp. 472–476. doi: 10.1007/s00508-015-0713-y. Moore, N., Pollack, C. and Butkerait, P. (2015) ‘Adverse drug reactions and drug – drug interactions with over-the-counter NSAIDs’, Therapeutics and Clinical Risk Management, pp. 1061–1075. Ogston, S. A. et al. (1991) ‘Adequacy of Sample Size in Health Studies.’, Biometrics, 47(1), p. 347. doi: 10.2307/2532527. Pernod, G. et al. (2008) ‘EDUC’AVK: Reduction of oral anticoagulant-related adverse events after patient education: A prospective multicenter open randomized study’, Journal of General Internal Medicine, 23(9), pp. 1441–1446. doi: 10.1007/s11606-008-0690-1. Rahmani, P. et al. (2016) ‘Association between patient knowledge of anticoagulation, INR control, and warfarin-related adverse events’, Journal of Pharmacy Technology, 32(4), pp. 150–159. doi: 10.1177/8755122516644622. Shrestha, S. et al. (2015) ‘Evaluation of patients ’ knowledge on warfarin in outpatient pharmacy of a tertiary care cardiac center’, BMC Research Notes, pp. 1–5. doi: 10.1186/s13104-015-1416-1. Shrestha, S. et al. (2020) ‘Impact of Pharmacists ’ Counseling in Patients ’ Knowledge of Warfarin in a Tertiary Care Cardiac Centre : A Prospective Randomized Controlled Study’, 13(2). doi: 10.5530/ijopp.13.2.26. Viola, R., Fekete, H. and Csoka, I. (2017) ‘Patients ’ knowledge on oral anticoagulant treatment in Hungary’, International Journal of Clinical Pharmacy, 39(6), pp. 1265–1272. doi: 10.1007/s11096-017-0544-1. Violi, F. et al. (2016) ‘Interaction between dietary Vitamin K intake and anticoagulation by Vitamin K antagonists: is it really true?: A systematic review’, Medicine (United States), 95(10), pp. 1–7. doi: 10.1097/MD.0000000000002895. Wang, Y. et al. (2014) ‘Knowledge, satisfaction, and concerns regarding warfarin therapy and their association with warfarin adherence and anticoagulation control’, Thrombosis Research, 133(4), pp. 550–554. doi: 10.1016/j.thromres.2014.01.002. Zahid, I. et al. (2020) ‘Are patients on oral anticoagulation therapy aware of its effects ? A cross ‑ sectional study from Karachi , Pakistan’, BMC Research Notes, pp. 1–8. doi: 10.1186/s13104-020-05119-w.

DOI: https://doi.org/10.22146/farmaseutik.v18i4.66925