Formulation of Orally Disintegrating Tablet from Nifedipin-β-siklodekstrin Inclusion Complex using Kneading Method

Nur Aini Purnamasari; Pratama Anggi Saputra

doi:10.22146/farmaseutik.v15i1.45262

Formulation of Orally Disintegrating Tablet from Nifedipin-β-siklodekstrin Inclusion Complex using Kneading Method

https://doi.org/10.22146/farmaseutik.v15i1.45262

Nur Aini Purnamasari^(1*), Pratama Anggi Saputra⁽²⁾

(1) Fakultas Farmasi Universitas Setia Budi
(2) Fakultas Farmasi Universitas Setia Budi
(*) Corresponding Author

Abstract

Nifedipine is widely used for managing hypertension. The challenges of developing nifedipine oral preparation are its low solubility and unpleasant taste. The purpose of developing the Oral Disintegrating Tablet (ODT) dosage form from the Nifedipine-β-cyclodextrin inclusion complex is to increase the solubility of nifedipine and mask the unpleasant taste of the drug. Specific target: use of a superdisintegrant combination to increase the solubility of nifedipine and mask the bitter taste. The method used in the formation of Nifedipine inclusion complex with β-cyclodextrin was kneading method. Making ODT was done by direct pressing method. Characterization of nifedipine-β-cyclodextrin inclusion complex was analyzed by FTIR and DSC. ODT was tested for the physical properties of the tablet and its solution. Test results for ODT physical properties were analyzed and compared with the literature. Data obtained from the dissolution test results calculated the concentration of the active substance dissolved at 20 minutes (Q₂₀). The results showed that the formation of the Nifedipine-β-cyclodextrin inclusion complex increased solubility and masked the bitter taste. The combination of superdisintegrant Ac-Di-Sol-Crosspovidon accelerated the disintegration and dissolution time and improve the taste of Nifedipine ODT.

Keywords

Nifedipine, Orally Disintegrating Tablet (ODT), inclusion complex, superdisintegrant

Full Text:

PDF

References

Ayenew, Z., Puri, V., Kumar, L. and Bansal, A.K., 2008, Trends in Pharmaceutical Taste Masking Technologies: A Patent Review, Recent Patent on Drug Delivery and Formulation, 3: 26-39.

Croom, Katherine F, Wellington, Keri. Modified-release nifedipine: A review of the use of modified release formation in the treatment of hypertension and Angina pectoris. Drugs; 2006; 66 Suppl 4: 497-528.

Hiroyuki, O,. Atsuo, M,. Takurou, K,. Yuji, M,. Yosunori, I., Takashi, S., Shigeru, I., 2009, Frezee-dried nifedipine-lipid nanoparticles with long-term nano-dispersion stability after reconstitution. Int. J.Pharm., v.377, p.180-184.

Jain, C.P. and Naruka, P.S., 2009, Formulation and Evaluation of Fast Dissolving Tablets of Valsartan, International Journal of Pharmacy and Pharmaceutical Science, 1: 219-221.

Mangal, M., Thakral, S., Goswani, M. and Ghai, P., 2012, Superdisintegrant: An Update Review, International Journal of Pharmacy and Pharmaceutical Science, 2 (2): 26-35.

DOI: https://doi.org/10.22146/farmaseutik.v15i1.45262