Keracunan Coklat (Theobroma Cacao) pada Anjing: Manajemen Terapi dan Pencegahan
Yanuartono Yanuartono(1*), Alfarisa Nururrozi(2), Soedarmanto Indarjulianto(3), Slamet Raharjo(4), Hary Purnamaningsih(5), Nurman Haribowo(6)
(1) Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Hewan Universitas Gadjah Mada
(2) Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Hewan Universitas Gadjah Mada
(3) Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Hewan Universitas Gadjah Mada
(4) Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Hewan Universitas Gadjah Mada
(5) Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Hewan Universitas Gadjah Mada
(6) Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran Hewan Universitas Gadjah Mada
(*) Corresponding Author
Abstract
susceptible. Contributing factors include indiscriminate eating habits and readily available sources of chocolate.
In general, the poisoning resulted from a lack of public knowledge of the health hazard to dogs that may be
imposed by these products. Chocolate is derived from the seeds of the plant Theobroma cacao, and the main toxic
components are the methylxanthine alkaloids theobromine and caffeine, causing gastrointestinal, cardiovascular
and central nervous signs. Diagnosis is based on history of exposure, along with clinical signs. Amphetamine or
cocaine toxicosis, and ingestion of antihistamines, antidepressants, or other CNS stimulants should be considered
in the differential diagnosis. Stabilization of symptomatic animals is a priority in treating chocolate toxicosis.
Although there is no specific antidote, supportive management includes induction of vomiting and administration
of activated charcoal, oxygen, and intravenous fluids. Preventing exposure is the key to reducing the incidence
of these poisoning episodes. Therefore, it is important to increase the knowledge of dogs owners with regard to
foodstuffs that must not be fed to dogs and should be stored outside their reach. This paper aims to briefly describe
the clinical symptoms, treatment and prevention of chocolate poisoning in dogs.
Keywords
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Ackar, D., Landic, K.V., Valek, M., Subaric,D., Milicevic, B., Babic, J. and Nedic,H. (2013). Cocoa polyphenols : can weconsider cocoa and chocolate as potentialfunctional food. Journal of Chemistry. 2013( Article ID 289392): 1-7. http://dx.doi.org/10.1155/2013/289392
Agudelo, C.F., Filipejova, Z. and Schanilec, P.(2013). Chocolate ingestion-induced noncardiogenic pulmonary oedema in a puppy:a case report. Veterinarni Medicina, 58 (2):109–112. DOI:10.17221/6703-vetmed
Ahlawat, A.R., Ghodasara, S.N., Dongre, V.B. and Gajbhiye, P.U. (2014). Chocolate Toxicity In A Dog. Ind. J. Vet. & Anim. Sci. Res., 43(6): 452 – 453.
Albretsen, J.C. (2004). Methylxanthines. In:Plumlee KH (ed.): Veterinary Clinical Toxicology. 1st ed. Mosby Inc., St. Louis,
MO. 322–326.
Aly, Z.H. 1981. Untersuchungenüber coffein undtheobromin bei schafen III. Mitteilung:Verfütterung von Kakoschalen. Zbl. Vet.
Mrd. A 28 (9-10): 711-719. https://doi.org/10.1111/j.1439-0442.1981.tb01242.x
Aregheore, E.M. (2002). Chemical evaluation adn digestibilityt oc cocoa (Theobroma cacao) bypbroducts fed to goats. Tropical Animal. Health and Production. 34(4): 339-348. DOI:10.1023/a:1015638903740
Atkinson, M. (2008). Suspected case of Angel’s near ‘death by chocolate’ experience. https://www.vettimes.co.uk › uploads › wppost-to-pdf-enhanced-cache › s. Beasley, V. (1999). Toxicants associated with stimulation or seizures. In: VeterinaryKeracunan Coklat (Theobroma Cacao) pada Anjing: Manajemen Terapi dan Pencegahan toxicology. Beasley V, editor. Ithaca NY:International Veterinary information service
Berny, P., Caloni, F., Croubels, S., Sachana,M., Vandenbroucke, V., Davanzo, F.and Guitart, R. (2010). Animal poisoning in Europe. Part 2: Companion animals. Vet J. 183(3):255-9. doi: 10.1016/j.
tvjl.2009.03.034.
Black, D.J.G. and Barron, N.S. (1943). Observations on the feeding of a cacao waste product to poultry. The Veterinary
Record. 55: 166-167.
Bonati, M., Latini, R., Sadurska, B., Riva, E.,Galletti, F., Borzelleca, J. F., Tarka, S.M., Arnaud, M.J. and Garattini, S, (1984). Kinetics and metabolism of theobromine in male rats. Toxicology 30(4): 327–341. doi:10.1016/0300-483X(84)90143-4
Buchweitz, J.P., Raverty, S.A., Johnson, M.B. and Lehner, A.F. 2014. Fatal diphenhydramine poisoning in a dog. Can Vet J. 55(11):1089–1092. PMCID: PMC4204843
Caloni, F., Berny, P., Croubels, S., Sachana, M. and Guitart, R. (2012). Epidemiology of animal poisonings in Europe. 2nd ed In: Gupta RC, editor., editor. Veterinary Toxicology: Basic and Clinical Principles. San Diego, CA: Elsevier Inc. pp. 88–97
Campbell, A. (2007). Grapes, raisins and sultanas, and other foods toxic to dogs.UK Vet Companion Animal 12(1): 77-79.
https://doi.org/10.1111/j.2044-3862.2007.tb00121.x
Carson, T.L. (2006). Methylxanthines. In:Peterson ME, Talcott PA (eds.) Small Animal Toxicology. 2nd ed. Saunders, St.Louis, MO. 845–852
Chin, E., Miller, K.B., Payne, M.J., Hurst, W.J.and Stuart, D.A. (2013). Comparison of antioxidant activity and flavanol content
of cocoa beans processed by modern and traditional esoamerican methods.Heritage Science 1(1) : 1-7. http://dx.doi.org/10.1186/2050-7445-1-9
Cortinovis, C. and Caloni, F. (2016). Household Food Items Toxic to Dogs and Cats. Front. Vet. Sci. 3 (26): 1-7. doi: 10.3389/
fvets.2016.00026
Craft, E.M. and Powell, L.L. (2010). Chocolate and caffeine. In: Osweiler GD, Hovda LR, Brutlag AG, Lee JA, editors. Blackwell’s
Five-Minute Veterinary Consult Clinical Companion: Small Animal Toxicology. Ames, IA: Wiley-Blackwell p. 421–428.
Cruz, J.F.M., Leite, P.B., Soares, S.E. and da Silva Bispo, E. (2015). Bioactive compounds in different cocoa (Theobroma cacao, L) cultivars during fermentation. Food Sci. Technol, Campinas. 35(2): 279-284. DDOI:http://dx.doi.org/10.1590/1678-457X.6541
Hanington, E. and Bell, H. (1972). Suspected chocolate poisoning of calves. Vet. Rec. 90 (14): 408-409. DOI:10.1136/vr.90.14.408
Decker, R.A. and Myers, G.H. (1972). Theobromine poisoning in a dog. J Am Vet Med Assoc. 161(2):198-199. PMID:5036186
Diniz, P.P., Sousa, M.G, Gerardi, D.G. and TinucciCosta, M. 2003). Amphetamine poisoning in a dog: Case report, literature review and veterinary medical perspectives. Vet hum toxicol. 45(6):315-317. PMID:14640484
Dolder, L.K. (2013). Methylxanthines: caffeine, theobromine, theophylline. 3rd ed. In:Petersen ME, Talcott PA, editors. Small
Animal Toxicology. St. Louis, MO.Saunders p. 647–52.
Erling, P. and Mazzaferro, E.M. (2008). Left-sided congestive heart failure in dogs: treatment and monitoring of emergency patients. Compendium on Continuing Education for the Practicing Veterinarian 30: 94–104.
Eteng, M.U., Eyong, E.U., Akpanyung,E.O., Agiang, M.A. and Aremu, C.Y. (1997). Recent advances in caffeine and theobromine toxicities: a review. Plant Foods Hum Nutr. 51(3):231–243. DOI:10.1023/a:1007976831684
Farbman, D.B. (2000). 10 Common toxicant exposures in animals, part I. Champaign, IL,Parkland Coll Fall Conf Proc, October 7.
Farbman, D.B. (2001). Death by Chocolate ?Methylxanthine Toxicosis. Vet Tech 146-147
Finlay, F. (2005). Chocolate poisoning. BMJ.331(7517): 633. PMCID: PMC1215566
Gans, J.H., Korson, R., Cater, M.R. and Ackerly, C.C. (1980). Effects of shortterm and longterm theobromine administration to male dogs. Toxicol Appl Pharmacol. 53(3):481-496. https://doi.
org/10.1016/0041-008X(80)90360-9
Gwaltney-Brant, S.M. 2001. Chocolate intoxication. Vet Med. 96:108-111.
Gwaltney-Brant S.M. 2012. Toxicology V.Epidemiology of animal poisonings in the United States: Elsevier: 80–87.
Hammerstone, J.F., Lazarus, S.A., Mitchell, A.E.,Rucker, R. and Schmitz, H.H. (1999). Identification of procyanidins in cocoa
(Theobroma cacao) and chocolate using high-perfomance liquid chromatography/mass spectrometry. J. Agric. Food Chem.
(2): 490-496. DOI:10.1021/jf980760h
Hansen, S., Trammel, H., Dunayer, E., Gwaltney,S., Farbman, D. and Khan, S. (2003). Cocoa bean mulch as a cause of methylxanthine toxicosis in dogs. Journal of toxicology
Clinical toxicology.41: 720. doi:10.1081/CLT-120024368
Hensel, M., Pashmakova, M. and Porter, B.F.(2017). Fatal caffeine intoxication in a dog.
Braz J Vet Pathol. 10(2): 65 – 68. DOI:10.24070/bjvp.1983-0246.v10i2p65-68
Hooser, S.B. and Beasley, V.R. (1986).Methylxanthine poisoning (chocolate and caffeine toxicosis). In: Current Veterinary
Therapy small animal practice IX, R.W: Kirk (Ed.), W.B. Saunders, Philadelphia,Pennsylvania, pp. 191-192.
Hornfeldt, C.S. (1987). Chocolate toxicity in dogs. Mod Vet Pract. 68:552-554.
Hovda, L.R. and Kingston, R.L. (1994). Cacao bean mulch poisoning in dogs. Vet Muman Toxicol. 36:3.
Hudd, A. (1997). Chocolate Poisoning in the Dog. Veterinary Nursing Journal. 12(2):54-55,DOI: 10.1080/17415349.1997.11012885
Iannaccone, J. (1999). Chocolate Toxicity. https://www.addl.purdue.edu › newsletters › spring› choc
Jansson, D.S., Galgan, V., Schubert, B. and Segerstad, C.H. (2001). Theobromine Intoxication in a Red Fox and a
European Badger in Sweden. Journal of Wildlife Diseases, 37(2): 362–365.DOI:10.7589/0090-3558-37.2.362
Johnston, J.J. (2005). Evaluation of coca- and coffee-derived methylxanthines as toxicants for the control of pest coyotes. J Agric. Food. Chem. 53: 4069-4075.
Kang, M.H. and Park, H.M. 2012. Application of carvedilol in a dog with pseudoephedrine toxicosis-induced tachycardia. Can Vet J.
(7):783–786. PMCID: PMC3377463
Kelly, W.R. and Lambert, M.B. (1978). The use of cocoa-bean mealin the diets of horses:Pharmacology and pharmacokinetics
of theobromine. Br. Vet. J. 134(2): 171-180. https://doi.org/10.1016/S0007-1935(17)33542-X
Kovalkovicova, N., Sutiakova, I., Pistl, J. and Sutiak, V. (2009). Some food toxic for pets.Interdiscip Toxicol. 2 (3): 169-176. https://doi.org/10.2478/v10102-009-0012-4
Kowalska, J. and Sidorczuk, A. (2007). Analysis of the effect of technoligical processing on changes antioxidant properties of cocoa processed Products. Pol J Food Nutr Sci.57 (2A): 95-99.
Lee, K.W., Yamato, O., Tajima, M., Kuraoka,M., Omae, S. and Maede, Y. (2000).Hematologic changes associated with
the appearance of eccentrocytes after intragastric administration of garlic extract to dogs. Am J Vet Res. 61(11): 1446–1450.
https://doi.org/10.2460/ajvr.2000.61.1446
Loeffler, B. 2000. Untersuchungen zur Pharmakokinetik von Coffein, Theophyllin und Theobromin beim Hund nach
Aufnahme von Kaffee, Tee und Schokolade. Dissertation. Aus dem Institut für Pharmakologie, Pharmazie und Toxikologie
der Veterinärmedizinischen Fakultät der Universität Leipzig. 104 pp.
Luiz, J.A. and Heseltine, J. (2008). Five common toxins ingested by dogs and cats. Compend Contin Educ Vet. 30(11): 578 –587.
PMID:19140100
Mahdi, A., and Van der Merwe, D. (2013). Dog and cat exposures to hazardous substances reported to the Kansas State Veterinary Diagnostic Laboratory: 2009-2012. J Med Toxicol. 9 (2): 207–11.10.1007/s13181-013-0289-8
Martínez-Pinilla, E., Oñatibia-Astibia, A. and Franco, R. (2015). The relevance of theobromine for the beneficial effects of
cocoa consumption. Front. Pharmacol. 6(30):1-5. doi: 10.3389/fphar.2015.00030
Mazzaferro, E.M., Eubig, P.A., Hackett, T.B., Legare, M.E., Miller, C., Wingfield, W.E.and Wise, L. (2004). Case report: Acute
renal failure associated with raisin or grape ingestion in 4 dogs. J Vet Emerg Crit Care. 14(3):203–212. DOI: 10.1111/j.1534-
2004.00114.x
McFarland, S.E., Mischke, R.H., Hopster-Iversen, C., von Krueger, X., Ammer, H., Potschka,H., Stürer A., Begemann, K., Desel, H. and Greiner, M. (2017). Systematic account of animal poisonings in Germany, 2012-2015. Vet Rec. 180(13):327. doi: 10.1136/
vr.103973.
Merck Veterinary Manual (2005). Chocolate Poisoning. (Toxicology/Food hazards section), Merk & Co., Inc.,
Merck Veterinary Manual (2019). Chocolate Toxicity. https://www.merckvetmanual.com › StandaloneMedia
Miller, G.E., Radulovic, L.L., Dewit, R.H., Brabec, M.J., Tarka, S.M. and Cornish, H.H. (1984). Comparative Theobromine Metabolism
In Five Mammalian Species. Drug Metab Dispos. 12(2): 154-160. PMID:6144479
Monteiro, J.P., Alves, M.G., Oliveira, P.F. and Silva, B.M. (2016). Structure-Bioactivity Relationships of Methylxanthines: Trying
to Make Sense of All the Promises and the Drawbacks. Molecules. 21(974): 1-32;doi:10.3390/molecules21080974
Mourya, S., Bodla, R., Taurean, R. and Sharma, A.(2019). Simultaneous estimation of xanthine alkaloids Theophylline, Theobromine and Caffeine by HPLC. International Journal
of Drug Regulatory Affairs 7(2): 35-41.DOI https://doi.org/10.22270/ijdra.v7i2.315
Noble, P.J.M., Newman, J., Wyatt, A.M., Radford,A.D. and Jones, P.H. (2017). Heightened risk of canine chocolate exposure at Christmas and Easter. Vet. Rec.181 (25): 1-2. http://
dx.doi.org/10.1136/vr.104762
Odunsi, A.A. and Longe, O.G. (1998). The nutritive value of hot water or cocoa pod ash solution treated cocoa bean cake for
broiler chicks. Br Poult. Sci. 39(4):519-525. DOI:10.1080/00071669888700
Othman, A., Ismail, A., Ghani, N.A. and Adenan, I. (2007). Antioxidant capacity and phenolic content of cocoa beans.
Food Chemistry. 100(4):1523-1530. DOI: 10.1016/j.foodchem.2005.12.021
Pittenger, S. (2002). Chocolate (methylxanthine) intoxication. Harris County Vet. Med. Assoc. Newsletter. pp2
Plumb, D.C. (1999). Veterinary Drug Handbook.3rd ed. Iowa State University Press, Ames,IA, pp. 118; 424.
Reddy, B.S., Reddy, L.S.S.V. and Sivajothi, S.(2013). Chocolate Poisoning in a Dog, Int J Vet Health Sci Res. 01(03): 16-17. doi:
http://dx.doi.org/10.19070/2332-2748-130004
Reich, M.R., Ohad, D.G., Overall, K.L. and Dunham. A.E. (2000). Electrocardiographic assessment of antianxiety medication in
dogs and correlation with serum drug concentration. J Am Vet Med Assoc. 216(10): 1571–1575. DOI:10.2460/javma.2000.216.1571
Reising, C.A., Chendrasekhar, A., Wall, P.L.,Paradise, N.F., Timberlake, G.A. and Moorman, D.W. (1999). Continuous dose
furosemide as a therapeutic approach to acute respiratory distress syndrome (ARDS).J Surg Res. 82(1): 56–60. DOI:10.1006/jsre.1998.5513Yanuartono, et. al.
Richelle, M., Tavazzi, I., Enslen, M.and Offord,E.A. (1999). Plasma kinetics in man of epicatechin from black chocolate. Eur J Clin Nutr. 53(1): 22-26. http://dx.doi.org/10.1038/ sj.ejcn.1600673.
Serafin, W.E. (1996). Drugs used in the treatment of asthma. In: Goodman and Gilman’s The Pharmacologic basis of Therapeutics, 9th ed. J.G.Hardman, et al, eds. McGraw Hill, New Yark, NY, pp. 672-678.
Shively, C.A. and Tarka, S.M. (1984). Methylxanthine composition and consumption patterns of cocoa and chocolate products. Prog. Clin. Biol. Res. 158: 149-78. DOI:10.1201/9780429126789-7
Smit, H.J. (2011). Theobromine and the pharmacology of cocoa. In: Fredholm BB (ed.): Methylxanthines, Handbook
of Experimental Pharmacology. 1st ed. Springer Verlag, Berlin, Heidelberg. 201–234
Stavric, B. (1988). Methylxanthines: Toxicity to humans, theobromine, paraxanthine and the combined effects of ethylxanthines. Food Chem. Toxicol. 26(8): 725-733.
DOI:10.1016/0278-6915(88)90073-7
Stidworthy, M.F., Bleakley, J.S., Cheeseman, M.T.and Kelly, D.F. (1997). Chocolate poisoning in dog. Vet. Rec. 141(1): 28. PMID:9248028
Strachan, E.R. and Bennett, A. (1994). Theobomine poisoning in dogs. Vet. Rec. 134(11): 284.http://dx.doi.org/10.1136/vr.134.11.284
Sutton, N.M., Bates, N. and Campbell, A. (2009). Factors influencing outcome of Vitis vinifera (grapes, raisins, currants and
sultanas) intoxication in dogs. Vet Rec. 164 (14): 430–431. DOI: 10.1136/vr.164.14.430
Tarka, S.M., Applebaum, R.S. and Borzelleca,J.F. (1986). Evaluation of the teratogenic potential of cocoa powder and
theobromine in New Zealand white rabbis.Food ChemToxicol. 24(5): 363-374.DOI:10.1016/0278-6915(86)90200-0
Tawde, S.N., Puschner, B., Albin, T., Stump, S.and Poppenga, R.H. (2012). Death by Caffeine: Presumptive Malicious Poisoning
of a Dog by Incorporation in Ground Meat.J. Med. Toxicol. 8:436–440 DOI 10.1007/s13181-012-0254-y
Tazzeo, T., Bates, G., Roman, H.N., Lauzon,A.M., Khasnis, M.D., Eto, M. and Janssen,L.J. (2012). Caffeine relaxes smooth muscle
through actin depolymerization. Am J Physiol Lung Cell Mol Physiol. 303(4):L334-342.doi: 10.1152/ajplung.00103.2012
Thomas, E.K., Drobatz, K.J. and mandell, D.C.(2014). Presumptive cocaine toxicosis in 19 dogs: 2004–2012. J Vet Emerg and
Crit care. 24(2):201-207. https://doi.org/10.1111/vec.12159
Thompson, A. (2012). Canine toxicology in the home environment. Veterinary Nursing Journal. 27(10): 380-382, DOI:
1111/j.2045-0648.2012.00226.x
Torres-Moreno, M., Torrescasana, E., SalasSalvado, J. and Blanch, C. (2015).Nutritional composition and fatty acids
profile in cocoa beans and chocolates with different geographical origin and processing conditions. Food Chem. 166:125–132. doi:
1016/j.foodchem.2014.05.141
Trognitz, B., Cros, E., Assemat, S., Davrieux, F., Forestier-Chiron, N., Ayestas, E.,Kuant, A., Scheldeman, X. and Hermann,
M. (2013). Diversity of cacao trees in Waslala, Nicaragua: Associations between genotype spectra, product quality and yield potential. PLoS ONE. ;8:e54079. doi:10.1371/journal.pone.0054079.
Wahyudi, T., Pujiyanto and Misnawi.(2015) Kakao: Sejarah, Botani, Proses Produksi, Pengolahan, dan Perdagangan (Yogyakarta: Gadjah Mada University Press)
Yamato, O., Kasai, E., Katsura, T., Takahashi, S.,Shiota, T., Tajima, M., Yamasaki, M. and Maede, Y. (2005). Heinz body hemolytic anemia with eccentrocytosis from ingestion of Chinese chive (Allium tuberosum) and garlic (Allium sativum) in a dog.
J Am Anim Hosp Assoc. 41(1): 68–73.
DOI:10.5326/0410068
Yang, H., Kerbger, J.A., Pettigrew, J.E., Johnston,L.J. and Walker, R.D. (1997). Evaluation of milk chocolate product as a substitute for whey in pig starter diets. J. Anim. Sci. 75(2):
429. DOI:10.2527/1997.752423x
Zoumas, B.L., Kreiser, W.R. and Martin, R.(1980).Theobromine And Caffeine Content Of Chocolate Products. J
Food Sci. 45(2): 314-316. https://doi.org/10.1111 j.1365-2621.1980.tb02603.x
DOI: https://doi.org/10.22146/jsv.60154
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