Suplementasi Calcitriol Menurunkan Risiko Osteoporosis Tikus Ovariektomi
Hartiningsih .(1*), Devita Anggraeni(2)
(1) Departemen Ilmu Bedah dan Radiologi, Fakultas Kedokteran Hewan, UGM
(2) Departemen Ilmu Bedah dan Radiologi, Fakultas Kedokteran Hewan, UGM
(*) Corresponding Author
Abstract
terlihat mempunyai lebih sedikit jaringan adiposit dan lebih banyak spikulum trabekula dibanding tikus KOV. Dari hasil penelitian disimpulkan bahwa suplementasi calcitriol 100ng/hari selama delapan minggu pada tikus ovariektomi menurunkan risiko osteoporosis.
Keywords
References
Daftar Pustaka
Anderson, G.L., Chlebowski, R.T. and Rossouw,
J.E. (2006) Prior hormone therapy and breast
cancer risk in the women's health initiative
randomized trial of estrogen plus progestin.
Maturutas. 55: 103-115.
Anderson, G.L., Limacher, M. and Assaf, A,R,
(2004) Effects of conjugated equine estrogen in
postmenopausal women with hysterectomy: the
women's health initiative randomized
controlled trial. JAMA. 291: 1701-1712.
Chang, K.L., Hu, Y.C., Hsieh, B.S., Cheng, H.L.,
Hsu, H.W., Huang, L.W. and Su, S.J. (2013)
Combined effect of soy isoflavones and vitamin
D3 on bone loss in ovariectomized rats.
Nutrition. 29: 250-257.
Cigiela, U., Folwarczna, J., Pytlik, M. and Zgorka,
G. (2012) Effect of extracts from Trifolium
medium L and Trifolium pratense L. on
development of estrogen deficiency-induced
osteoporosis in rats. Hindawi Publishing
Corporation. Based Complemantary and
Alternative Medicine. Article ID. 921684.
Goltzman, D. (2002) Discoveries, drugs and skeletal
disorders. Nat Rev drug Discov. 1: 784-796.
menurunkan
et al.
Hartiningsih dan Anggraeni, D. (2013) Kombinasi
calcitriol dan ethynil ethyl estradiol untuk
mencegah osteoporosis tikus ovariektomi.
Penelitian pengembangan bagian 2013
Fakultas Kedokteran Hewan Universitas
Gadjah Mada.
Hartiningsih, Anggraeni, D. dan Aji, D. (2012)
Respon metafisis tulang femur distalis tikus
ovariektomi yang mengkonsumsi kalsitriol. J.
Kedokteran Hewan 6: 92-98.
Hughes, D.E., Dai, A., Tiffee, J.C., Li, H.H., Mundy,
G.R. and Boyce, B.F. (1996) Estrogen promotes
apoptosis of murine osteoclasts mediated by
TGF-beta. Nat Med. 2: 1132-1136.
, J., Stenderus, K., Ebbesen, E.N.,
Moseklide, L., Steinche, T. and Kassem, M.
(2001) Adipocyte tissue volume in bone
marrow is increased with aging and in patients
with osteoporosis. Biogerontolog. 2(3): 165-
Karsdal, M.A., Martin, T.J., Bollerslev, J.,
Christiansen, C. and Henriksen, K. (2007) Are
nonresorbing osteoclasts sources of bone
anabolic activity ? J. Bone Miner. Res. 22: 487-
Kong, J. and Li, Y.C. (2006) Molecular mechanism
of 1, 25-dihydroxyvitamin D3 inhibition of
adipogenesis in 3T3-L1 cells. Am. J. Physiol.
Endocrinol. Metab. 290: E916–E924.
Martin, T.J. and Sims, N.A. (2005) Osteoclast
derived activity in the coupling of bone
formation to resorption. Trend. Mol. Med. 11:
-81.
Nakamura, M., Udagawa, N., Matsuura, S., Mogi,
M., Nakamura, H., Horiuchi, H., Saito, N.,
Hiraoka, B.Y., Kobayashi, Y., Takaoka, K.,
Ozawa, H., Miyazawa, H. and Takahashi, N.
(2003) Osteoprotegerin regulates bone
formation through a coupling mechanism with
bone resorption. Endocrinology. 144: 5441-
Justesen
Mohr, S.B., Garland, C.F., Gorham, E.D., Grant,
W.D. and Garland, F.C. (2007) Is ultraviolet B
irradiance inversely associated with incidence
rates of endometrial cancer: an ecological study
of 107 countries. Prev. Med. 45: 327-331.
Hartiningsih dan Devita Anggraeni
Palmer, N. (1993) Bones and Joints. In Pathology of
domestic animals. Jubb, KVF., Kennedy PC,
and Palmer N. ed. Academic Press, Inc,
Harcourt Brace Jovanovich publishers, San
Diego: 1-181.
Potu, B.K., Nampurath, G.K., Chamallamudi, M.R.,
Prasad, K., Nayak, S.R., Dharmavarapu, P.K.,
Kedage, V. and Bath, K.M. (2009) Evidencebased
assesment antiosteoporotic activity of
petrolium ether extract of ossus quadrangularis
linn : on ovariectomy-induced osteoporosis.
Ups. J. Med. Sci. 114: 140-148.
Qu, Q., Perala-Heape, M., Kapanen, A., Dahllund, J.,
Salo, J., Vaananen, H.K. and Harkonen, P.
(1998) Estrogen enhances differentiation of
osteoblasts in mouse bone marrow culture.
Bone. 22: 201-209.
Rodan, G.A. and Martin, T.J. (2000) Therapeutic
approaches to bone diasease. Science. 289:
-1514.
Rossouw, J.E, Anderson, G.L., Prentilce, R.L.,
LaCroix, A.Z., Kooperberg, C., Stefanick,
M.L., Jackson, R.D., Beresford, S.A., Howard,
B.V., Johnson, K.C., Kotchen, J.M. and
Ockene, J. (2002) Risk and benefits of estrogen
plus progestin in healthy postmenopausal
women:principal results from the Women's
Health Inisiative randomized controlled trial.
JAMA. 288: 321-333.
Salazar-Martinez, E., Lazcano-Ponce, E., Sanchez-
Zamorano, L. M., Gonzales-Lira, G., Escudero-
DE Los R.P. and Hernandes-Avila, M. (2005)
Dietary factors and endometrial cancer risk.
Results of a case-control study in Mexico. In J.
Gynecol. Cancer. 15: 938-945.
Seeman, E., Vellas, B., Benhamou, C., Aquino, J.P.,
Semler, J., Kaufman, J.M., Hoszowski, K.,
Varela, A.R., Fiore, C., Brixen, K., reginster,
J.Y. and Boonen, S. (2006) Strontium ranelate
reduce the risk of vertebral and nonvertebral
fractures in women eighty years of age and
older. J. Bone Miner. Res. 21: 1113-1120.
Shiraishi, A., Takeda, S., Masaki, T., Higuchi, Y.,
Uchiyama, Y., Kubodera, N., Sato, K., Ikeda,
K., Nakamura, T., Matsumoto, T. and Ogata, E.
(2000) Alfacalcidol inhibits bone resorption
and stimulates formation in an ovariectomized
rat model of osteoporosis: distinct actions from
estrogen. J. bone Miner .Res. 15: 235-244.
Shuid, A.N., Ping, L.L., Muhammad, N. and
Soelaiman, I.N. (2011) The effects of labisia
pumila var alata on bone markers and bone
calcium in a rat model of post-menopausal
osteoporosis. Ehnopharmacol. 133(2): 538-
Strait, K.Y., Li, Y., Dillehay, D.L. and Weitzmann,
M.N. (2008) Supression of NF-Kappa B
activation blocks osteoclastic bone resorption
during estrogen deficiensy. Int. J. Mol. Med.
(4): 521-525.
Sun, X. and Zemel, M.B. (2004) Role of uncoupling
protein 2 (UCP2) expression and 1alpha, 25-
dihydroxyvitamin D3 in modulating adipocyte
apoptosis. Faseb. J. 18: 1430-1432.
Teitelbaum, S.L. (2000) Bone resorption by
osteoclasts. Science. 289: 1504-8
Teitelbaum, S.L. and Ross, F.P. (2003) Genetic
regulation of osteoclast development and
function. Nat. Rev. Genet. 4: 638-649.
Verma, S., Rajaratnam J.H., Denton J., Hoyland J.A.
and Byers R.J. (2002) Adipocytic proportion of
bone marrow is inversely related to bone
formation in osteoporosis. J. Clin. Pathol. 55:
-698.
Weisberg, S.P. McCann, D., Desai, M., Rosenbaum,
M., Leibel, R.L. and Ferrante, A.W. (2003)
Obesity is associated with macrophage
accumulation in adipose tissue. J. Clin. Invest.
(12): 1785-1808.
Zarate, A., Hernandez-Valencia, M., Saucedo, R.,
Basurto, L. and Manuel-Apolinar, L. (2014)
Current position about the use of estrogen
therapy in women during the menopause
period. Rev. Med. Inst. 52(1): 66-69.
Zhou, Y.S., Liu, Y.S. and Tan, J.G. (2006) Is 1, 25-
dihydroxyvitamin D3 an ideal substitute for
dexamethasone for inducing osteogenic
differentiation of human adipose tissue-derived
stromal cells in vitro? Chin. Med. J. (Engl). 119:
-1286.
DOI: https://doi.org/10.22146/jsv.17887
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