Evaluation of Antibiotic Use in the Internal Medicine Ward and ICU at Universitas Tanjungpura Hospital Pontianak with ATC/DDD

https://doi.org/10.22146/jmpf.92330

Dzuria Adhana Rifdah(1), Hariyanto Ih(2), Delima Fajar Liana(3*), Mardhia Mardhia(4), Mahyarudin Mahyarudin(5)

(1) Pharmacy Study Program, Faculty of Medicine, Tanjungpura University, Pontianak, West Kalimantan
(2) Pharmacy Study Program, Faculty of Medicine, Tanjungpura University, Pontianak, West Kalimantan
(3) 1) Department of Microbiology, Faculty of Medicine, Tanjungpura University, Pontianak, West Kalimantan 2) Universitas Tanjungpura Hospital, Pontianak, West Kalimantan, Indonesia
(4) Department of Microbiology, Faculty of Medicine, Tanjungpura University, Pontianak, West Kalimantan
(5) Department of Microbiology, Faculty of Medicine, Tanjungpura University, Pontianak, West Kalimantan
(*) Corresponding Author

Abstract


Background: Evaluating the wise use of antibiotics is needed to control antibiotic resistance in hospitals.

Objectives: This study aimed to analyze patient characteristics, antibiotic profiles, and quantitative use of antibiotics in inpatients prescribed by internal medicine specialists in the internal medicine ward and Intensive Care Unit (ICU) at Universitas Tanjungpura Hospital Pontianak from August to October 2022.

Methods: This study method is descriptive observational, and data collection was done retrospectively using a purposive sampling technique. There were 143 samples that met the inclusion criteria, and then using the Anatomical Therapeutic Chemical (ATC)/Defined Daily Dose (DDD) method, the samples were analyzed quantitatively.

Results: Most patient characteristics were female patients (60.14%), patients aged 56-65 (26.57%), and the most common diagnosis was typhoid fever (32.74%). Of the 13 types of antibiotics used, cephalosporin was the most commonly prescribed antibiotic group to patients (58.48%), with the most types of antibiotics in ceftriaxone (42,69%) and intravenous administration of antibiotics was the standard route given to patients. The results of the quantitative analysis of all antibiotic prescriptions obtained a total value of 88.55 DDD/100 patient-days. Antibiotics with the most considerable DDD/100 patient-days value were ceftriaxone (44.71), followed by meropenem (10.46) and levofloxacin (9.28). Furthermore, the value of DDD/100 patient-days is not an indicator in determining the rational use of antibiotics, so further study must be done using the Gyssens method.

Conclusion: The value of DDD/100 patient-days is not an indicator in determining the rational use of antibiotics, so further study must be done using the Gyssens method as qualitative evaluation to obtain information regarding the rationality of prescribing antibiotics.


Keywords


Anatomical Therapeutic Chemical; Defined Daily Dose; Sefalosporin; Seftriakson; Rumah Sakit Universitas Tanjungpura

Full Text:

PDF


References

  1. Octavianty C, Yulia R, Herawati F, Wijono H. Profil Penggunaan Antibiotik Profilaksis pada Pasien Bedah di Salah Satu RS Swata Kota Surabaya. Media Kesehatan Masyarakat Indonesia. 2021;20(3):168-172. doi:10.14710/mkmi.20.3.168-172
  2. World Health Organization. Global Antimicrobial Resistance and Use Surveillance System (GLASS) Report. World Health Organization; 2021.
  3. Anggraini W, Sugihantoro H, Ludfiyah F. Evaluasi Kuantitatif Penggunaan Antibiotik di Ruang Perawatan Airlangga dan Peta Kuman RSUD Kanjuruhan Malang Periode Juli-Desember 2018. Indonesian Journal of Clinical Pharmacy. 2021;10(2):90-99. doi:10.15416/ijcp.2021.10.2.90
  4. Kementerian Kesehatan Republik Indonesia. Peraturan Menteri Kesehatan Republik Indonesia Nomor 8 Tahun 2015 Tentang Program Pengendalian Resistensi Antimikroba Di Rumah Sakit. Kementerian Kesehatan Republik Indonesia; 2015.
  5. Rukminingsih F, Apriliyani A. ANALISIS PENGGUNAAN ANTIBIOTIK PADA PASIEN ANAK DI RUANG THERESIA RUMAH SAKIT ST. ELISABETH SEMARANG DENGAN METODE ATC/DDD. Jurnal Riset Kefarmasian Indonesia. 2021;3(1):26-34. doi:10.33759/jrki.v3i1.110
  6. Rachmawati S, Fazeri RL, Norcahyanti I. Gambaran Penggunaan Antibiotik di Bangsal Penyakit Dalam RSUD Bangil Kabupaten Pasuruan. JPSCR: Journal of Pharmaceutical Science and Clinical Research. 2020;5(1):12-21. doi:10.20961/jpscr.v5i1.35254
  7. Hollingworth S, Kairuz T. Measuring Medicine Use: Applying ATC/DDD Methodology to Real-World Data. Pharmacy. 2021;9(1):60. doi:10.3390/pharmacy9010060
  8. Hadi U, Duerink DO, Lestari ES, et al. Audit of antibiotic prescribing in two governmental teaching hospitals in Indonesia. Clinical Microbiology and Infection. 2008;14(7):698-707. doi:10.1111/j.1469-0691.2008.02014.x
  9. Zaccone V, Tosoni A, Passaro G, et al. Sepsis in Internal Medicine wards: current knowledge, uncertainties and new approaches for management optimization. Ann Med. 2017;49(7):582-592. doi:10.1080/07853890.2017.1332776
  10. Suarmayasa IN. POLA KUMAN PADA MANSET SPHYGMOMANOMETER : STUDI DESKRIPTIF DI RSD MANGUSADA. Jurnal Riset Kesehatan Nasional. 2023;7(2):163-168. doi:https://doi.org/10.37294/jrkn.v7i2.481
  11. Taslim E, Maskoen TT. Pola Kuman Terbanyak Sebagai Agen Penyebab Infeksi di Intensive Care Unit pada Beberapa Rumah Sakit di Indonesia. Majalah Anesthesia & Critical Care. 2016;34(1):33-39. https://macc.perdatin.org/index.php/my-journal/article/view/89
  12. Dirga D, Khairunnisa SM, Akhmad AD, Setyawan IA, Pratama A. Evaluasi Penggunaan Antibiotik pada Pasien Rawat Inap di Bangsal Penyakit Dalam RSUD. Dr. H. Abdul Moeloek Provinsi Lampung. Jurnal Kefarmasian Indonesia. 2021;11(1):65-75. doi:10.22435/jki.v11i1.3570
  13. Woro OQL, Suryani D, Dewi NMAR. Quantitative Evaluation Of Antibiotic Usage In ICU Ward at West Nusa Tenggara Province Hospital in 2018. Jurnal Kedokteran Syiah Kuala. 2023;23(1):152-157. doi:10.24815/jks.v23i1.24796
  14. Inez A, Nurmainah, Susanti R. Evaluation of Antibiotic Rationality for Pediatric Inpatient at Hospital of Tanjungpura University Period January–June 2018. Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN. 2019;4(1):1-15. https://jurnal.untan.ac.id/index.php/jmfarmasi/article/view/37615
  15. Putri SC, Untari EK, Yuswar MA. Profil Antibiotik pada Pasien Intensive Care Unit (ICU) di Rumah Sakit Dr. Soedarso Pontianak Periode Januari Juni 2019. Jurnal Mahasiswa Farmasi Fakultas Kedokteran UNTAN. 2019;4(1):1-7. https://jurnal.untan.ac.id/index.php/jmfarmasi/article/view/41437
  16. World Health Organization. ATC Index with DDDs. World Health Organization. Published 2023. Accessed January 10, 2023. http://www.whocc.no/atc-ddd-in-dex/
  17. Kementerian Kesehatan Republik Indonesia. Klasifikasi Umur Menurut Kategori. Direktorat Jenderal Pelayanan Kesehatan; 2009.
  18. Ridwan A, Narulita L, Widyadi ED, Suharjono S. Analisis Penggunaan Antibiotika pada Pasien Penyakit Dalam di RSUD Dr. H. Slamet Martodirdjo Pamekasan dengan Metode ATC/DDD. Jurnal Sains Farmasi & Klinis. 2019;6(3):237-242. doi:10.25077/jsfk.6.3.237-242.2019
  19. Rachmawati H, Muktamiroh M, Hasmono D, Kusumaningtyas AP, Yunita SL, Yusetyani L. Antibiotic Use Evaluation in ICU/HCU of Muhammadiyah University General Hospital Malang using DDD and Gyssens Methods. Jurnal Kedokteran Brawijaya. 2023;32(3):177-181. doi:10.21776/ub.jkb.2023.032.03.7
  20. Lestari PD, Utami ED, Suryoputri MW. Evaluation of Antibiotic Use in Ward of Internal Medicine RSUD Prof. Dr. Margono Soekarjo Purwokerto. Acta Phamaciae Indonesia. 2018;6(1):20-28. doi:10.5281/zenodo.3707171
  21. Díaz A, Beleña Á, Zueco J. The role of age and gender in perceived vulnerability to infectious diseases. Int J Environ Res Public Health. 2020;17(2):2-10. doi:10.3390/ijerph17020485
  22. Anggriani Y, Restinia M, Cikita Mitakda V, Kusumaeni T. Clinical Outcomes Penggunaan Antibiotik pada Pasien Infeksi Kaki Diabetik. Jurnal Sains Farmasi & Klinis. 2015;1(2):111-121. doi:https://doi.org/10.29208/jsfk.2015.1.2.27
  23. Kementerian Kesehatan Republik Indonesia. PERATURAN MENTERI KESEHATAN REPUBLIK INDONESIA NOMOR 28 TAHUN 2021 TENTANG PEDOMAN PENGGUNAAN ANTIBIOTIK.; 2021.
  24. Lestari DA, Wijaya V, Kuncoro H. Karakteristik dan Penggunaan Antibiotik Pasien Sepsis di Rumah Sakit Abdul Wahab Sjahranie Periode 2017. Proceeding of Mulawarman Pharmaceuticals Conferences. 2018;7(1):1-7. doi:https://doi.org/10.25026/mpc.v7i1.283
  25. Levani Y, Prastya AD. DEMAM TIFOID: MANIFESTASI KLINIS, PILIHAN TERAPI DAN PANDANGAN DALAM ISLAM. Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran. 2020;1(2):10-16. doi:10.26618/aimj.v3i1.4038
  26. Astutik AW, Annisa N, Rusli R, Ibrahim A. KAJIAN KESESUAIAN PEMILIHAN ANTIBIOTIK EMPIRIS PADA PASIEN SEPSIS DI INSTALASI RAWAT INAP RSUD ABDUL WAHAB SJAHRANIE SAMARINDA. Proceeding of the 5 th Mulawarman Pharmaceuticals Conferences. 2017;5(1):38-47. doi:https://doi.org/10.25026/mpc.v5i1.219
  27. Efliana M, Fadraersada J, Rijai L. KARAKTERISTIK DAN PENGOBATAN PASIEN PNEUMONIA DI INSTALASI RAWAT INAP RSUD ABDUL WAHAB SJAHRANIE SAMARINDA. Prosiding Seminar Nasional Kefarmasian Ke-4. 2016;4(1):205-214. doi:https://doi.org/10.25026/mpc.v4i1.183
  28. Wahidah LK, Wahyuni NT, Putri DM. EVALUASI PENGGUNAAN ANTIBIOTIK PNEUMONIA DENGAN METODE ATC/DDD PADA PASIEN PEDIATRI DI INSTALASI RAWAT INAP RSUD. DR. A. DADI TJOKRODIPO BANDAR LAMPUNG TAHUN 2019. Jurnal Farmasi Lampung. 2020;9(2):99-108. doi:10.37090/jfl.v9i2.338
  29. World Health Organization. GLASS: Manual on the Management of Antimicrobial Consumption Data. World Health Organization; 2020.
  30. World Health Organization. Guidelines for ATC Classification and DDD Assignment 2023. World Health Organization; 2022.
  31. Carolina M, Widayati A. EVALUASI PENGGUNAAN ANTIBIOTIKA DENGAN METODE DDD (DEFINED DAILY DOSE) PADA PASIEN ANAK RAWAT INAP DI SEBUAH RUMAH SAKIT PEMERINTAH DI YOGYAKARTA PERIODE JANUARI – JUNI 2013. Media Farmasi: Jurnal Ilmu Farmasi. 2014;11(1):81-89. doi:10.12928/mf.v11i1.1400
  32. Muslim Z, Novrianti A, Irnameria D. RESISTANCE TEST OF BACTERIAL CAUSES OF URINARY TRACT INFECTION AGAINST CIPROFLOXACIN AND CEFTRIAXONE ANTIBIOTICS. SANITAS: Jurnal Teknologi dan Seni Kesehatan. 2020;11(2):203-212. doi:https://doi.org/10.36525/sanitas.2020.19
  33. Oktaviana F, Noviana P. Efektivitas Terapi Antibiotika Demam Tifoid Pada Pediatrik Di Rumah Sakit X Kota Kediri. Journal Syifa Sciences and Clinical Research. 2021;3(2):63-70. doi:10.37311/jsscr.v3i2.11688
  34. Sonda TB, Horumpende PG, Kumburu HH, et al. Ceftriaxone use in a tertiary care hospital in Kilimanjaro, Tanzania: A need for a hospital antibiotic stewardship programme. Francis JM, ed. PLoS One. 2019;14(8):1-11. doi:10.1371/journal.pone.0220261
  35. Durham SH, Wingler MJ, Eiland LS. Appropriate Use of Ceftriaxone in the Emergency Department of a Veteran’s Health Care System. Journal of Pharmacy Technology. 2017;33(6):215-218. doi:10.1177/8755122517720293
  36. Baldwin CM, Lyseng-Williamson KA, Keam SJ. Meropenem: A Review of its Use in the Treatment of SeriousBacterial Infections. Drugs. 2008;68(6):803-838. doi:10.2165/00003495-200868060-00006
  37. Mosichuk AP, Smith JS, Tatarniuk DM, Troy JR, Kreuder AJ. Meropenem Administered via Intravenous Regional Limb Perfusion for Orthopedic Sepsis in Horses: A Clinical Retrospective Study. Front Vet Sci. 2021;8:1-10. doi:10.3389/fvets.2021.629627
  38. Andarsari MR, Norachuriya Z, Nabila SM, Aryani T, Rosyid AN. Assessment of Antibiotic Use in ICU Patients with Pneumonia Using ATC/DDD as a Quantitative Analysis Method. JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA. 2022;9(2):138-145. doi:10.20473/jfiki.v9i22022.138-145
  39. Ningsih S, Andriani Y, Rahmadevi R. Penggunaan Antibiotik Restriksi pada Pasien Ulkus, Abses dan Batu Kandung Kemih di Bangsal Bedah RSUD H. Abdul Manap Kota Jambi Periode 2017-2019. Jurnal Sains dan Kesehatan. 2021;3(3):359-364. doi:10.25026/jsk.v3i3.297



DOI: https://doi.org/10.22146/jmpf.92330

Article Metrics

Abstract views : 54 | views : 55

Refbacks

  • There are currently no refbacks.


Copyright (c) 2024 JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Jurnal Manajemen dan Pelayanan Farmasi
Faculty of Pharmacy
Universitas Gadjah Mada
Creative Commons License
View My Stats