Tinjauan Sistematis dan Meta-Analisis: Analisis Dampak Intervensi Apoteker terhadap Clinical Outcome Pasien Epilepsi

https://doi.org/10.22146/jmpf.82901

Najmah Salsabila(1), Jason Merari Peranginangin(2*), Dian Marlina(3)

(1) Program Studi S-2 Ilmu Farmasi Universitas Setia Budi Surakarta Jl. Letjen Sutoyo, Mojosongo, Kec. Jebres, Kota Surakarta, Jawa Tengah 57127
(2) Program Studi S-2 Ilmu Farmasi Universitas Setia Budi Surakarta Jl. Letjen Sutoyo, Mojosongo, Kec. Jebres, Kota Surakarta, Jawa Tengah 57127
(3) Program Studi S-2 Ilmu Farmasi Universitas Setia Budi Surakarta Jl. Letjen Sutoyo, Mojosongo, Kec. Jebres, Kota Surakarta, Jawa Tengah 57127
(*) Corresponding Author

Abstract


People with epilepsy generally experience impaired social contact and decreased health. The role of pharmacists in the implementation of therapy for epilepsy patients is very important in providing pharmaceutical services. This research was conducted to examine the impact of pharmacist intervention on the clinical outcome of epilepsy patients. The research method was a systematic review and meta-analysis with a randomized controlled trial study design. Articles were obtained through electronic databases such as PubMed, Directory of Open Access Journals (DOAJ), SpringerLink, ScienceDirect, and Wiley. Items were selected using the PRISMA flowchart. Articles were analyzed using Review Manager 5.3. The results obtained were 10 articles from various countries, namely England, Singapore, China, Thailand, Colombia, America, and Nigeria. The data obtained showed that the pharmacist's intervention had a positive impact by increasing the clinical outcome of epilepsy patients compared to the absence of a pharmacist (SMD = 0.56; 95% CI = 0.03 to 1.10; p = 0.04). Then there was high heterogeneity (I2) between experiments (I2 = 96%; p <0.001), this was due to the different population variations. Furthermore, from the results of merging these 10 articles, it was found that there was publication bias as seen from the funnel plot graph which looked asymmetrical between the right and left plots. The interventions provided by pharmacists, namely consultation and counseling proved to have a positive impact on the clinical outcome of epilepsy patients in the form of increasing quality of life by decreasing seizure frequency and increasing knowledge of epilepsy patients.


Keywords


clinical outcome; epilepsy Pharmacist

Full Text:

PDF


References

  1. Nahdhiyah AA, Ismiyati, Mulyanto B. Perbandingan Monoterapi Dan Politerapi Epilepsi Terhdap Kualitas Hidup Pasien Epilepsi Di Rsu Muhammadiyah Siti Aminah Bumiayu Tahun 2020. Pharm Perad J. 2021;1(1):22-31.
  2. Sari TE, Chundrayetti E. Faktor-Faktor Yang Mempengaruhi Quality of Life Pasien Epilepsi Yang Kontrol Ke Poliklinik Anak. 2021;6(2):320-327.
  3. Novianae L, Sumarno S. Ligan SV2A sebagai Terapi Epilepsi. J Farm Udayana. 2020;9(1):01. doi:10.24843/jfu.2020.v09.i01.p01
  4. KEMENKES. PEDOMAN NASIONAL PELAYANAN KEDOKTERAN TATA LAKSANA EPILEPSI PADA ANAK. 2017;(1):43. doi:10.1017/CBO9781107415324.004
  5. WHO. Epilepsy.; 2019. https://www.who.int/news-room/fact-sheets/detail/epilepsy
  6. Suryoputri MW, Endriastuti NE, Ilma DL. Effects of Antiepileptic Drug Levels on Clinical Outcomes in Pediatric Patients Using Pharmacokinetics Approach. Indones J Clin Pharm. 2021;10(4):272-288. doi:10.15416/ijcp.2021.10.4.272
  7. Sakthong P, Sangthonganotai T. A randomized controlled trial of the impact of pharmacist-led patient-centered pharmaceutical care on patients’ medicine therapy-related quality of life. Res Soc Adm Pharm. 2018;14(4):332-339. doi:10.1016/j.sapharm.2017.05.001
  8. Saputra, Ryan. et al. PENGARUH PEMBERIAN KONSELING APOTEKER PADA PASIEN HIV- AIDS DI POLIKLINIK RAWAT JALAN RS BHAYANGKARA TK I R. SAID SUKANTO. 2022;7(1).
  9. Fogg A, Staufenberg EF, Small I, Bhattacharya D. An exploratory study of primary care pharmacist-led epilepsy consultations. Int J Pharm Pract. 2012;20(5):294-302. doi:10.1111/j.2042-7174.2012.00207.x
  10. Chen C, Lee DSH, Hie SL. The impact of pharmacist’s counseling on pediatric patients’ caregiver’s knowledge on epilepsy and its treatment in a tertiary hospital. Int J Clin Pharm. 2013;35(5):829-834. doi:10.1007/s11096-013-9817-5
  11. Tang F, Zhu G, Jiao Z, Ma C, Chen N, Wang B. The effects of medication education and behavioral intervention on Chinese patients with epilepsy. Epilepsy Behav. 2014;37:157-164. doi:10.1016/j.yebeh.2014.05.017
  12. Losada-Camacho M, Guerrero-Pabon MF, Garcia-Delgado P, Martínez-Martinez F. Impact of a pharmaceutical care programme on health-related quality of life among women with epilepsy: A randomised controlled trial (IPHIWWE study). Health Qual Life Outcomes. 2014;12(1):1-11. doi:10.1186/s12955-014-0162-8
  13. Albert DVF, Moreland JJ, Salvator A, et al. Seizure Action Plans for Pediatric Patients With Epilepsy: A Randomized Controlled Trial. J Child Neurol. 2019;34(11):666-673. doi:10.1177/0883073819846810
  14. Ma M, Peng Q, Gu X, et al. Pharmacist impact on adherence of valproic acid therapy in pediatric patients with epilepsy using active education techniques. Epilepsy Behav. 2019;98:14-18. doi:10.1016/j.yebeh.2019.06.003
  15. Eshiet U, Okonta J, Ukwe C. The efficacy of a pharmacist implemented educational treatment programme for people with epilepsy: A report of a randomised controlled trial. Seizure. 2019;69(February):147-153. doi:10.1016/j.seizure.2019.04.011
  16. Eshiet UI, Okonta JM, Ukwe CV. Impact of a pharmacist-led education and counseling interventions on quality of life in epilepsy: A randomized controlled trial. Epilepsy Res. 2021;174(November 2020):106648. doi:10.1016/j.eplepsyres.2021.106648
  17. Eshiet UI, Okonta JM, Ukwe CV. Evaluating the impact of pharmaceutical care services on the clinical outcomes of epilepsy: a randomised controlled trial. Ir J Med Sci. 2021;191(2):885-894. doi:10.1007/s11845-021-02599-y
  18. Alajmi R, Al-Aqeel S, Baz S. The impact of a pharmacist-led educational interview on medication adherence of Saudi patients with epilepsy. Patient Prefer Adherence. 2017;11:959-964. doi:10.2147/PPA.S124028
  19. Retnawati H, Apino E, Kartianom, Djidu H, Anazifa RD. Pengantar Analisis Meta (Edisi 1).; 2018.
  20. Wibowo A, Putri S. Pedoman Praktis Penyusunan Naskah Ilmiah Dengan Metode Systematic Review. Dep Adm dan Kebijak Kesehat Fak Kesehat Masy Univ Indones. 2021;(July):2-45. doi:10.13140/RG.2.2.17871.20640
  21. Murti B. Prinsip Dan Metode Riset Epidemiologi Edisi 4.; 2018.



DOI: https://doi.org/10.22146/jmpf.82901

Article Metrics

Abstract views : 1338 | views : 1626

Refbacks

  • There are currently no refbacks.


Copyright (c) 2023 JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Jurnal Manajemen dan Pelayanan Farmasi
Faculty of Pharmacy
Universitas Gadjah Mada
Creative Commons License
View My Stats