Hubungan Kepatuhan Pengobatan Dengan Kualitas Hidup Pasien Gagal Ginjal Kronik Disertai Hipertensi dan Menjalani Hemodialisis

https://doi.org/10.22146/jmpf.69974

Agustina Nila Yuliawati(1*), Pande Made Desy Ratnasari(2), I Gusti Ayu Santhi Pratiwi(3)

(1) Program Studi Sarjana Farmasi, Sekolah Tinggi Farmasi Mahaganesha, Denpasar, Bali, Indonesia
(2) Program Studi Sarjana Farmasi, Sekolah Tinggi Farmasi Mahaganesha, Denpasar, Bali, Indonesia
(3) Program Studi Sarjana Farmasi, Sekolah Tinggi Farmasi Mahaganesha, Denpasar, Bali, Indonesia
(*) Corresponding Author

Abstract


End-stage renal disease (ESRD) patients undergoing hemodialysis (HD) could experience several problems, then reducing their quality of life (QOL). Medication adherence (MA), including HD is very important to improve the patient's QOL. This study aimed to analyze the correlation between MA and QOL and its related factors in ESRD patients. This cross-sectional study was conducted at a Public Hospital, Buleleng, Bali in September 2020. A sample of 89 people was obtained by the purposive sampling technique. The inclusion criteria for this study were ESRD patients aged ≥18 years, undergoing HD, filling out the questionnaire completely, and being able to communicate well. Data were collected using ERSD-AQ and EQ-5D-5L questionnaire, also medication records. Data analysis were performed by Perason’s rank correlation, Spearman’s rho, Kendall’s tau-b/c, Mann-Whitney U, or Kruskal Wallis test (CI 95%). Findings showed that mostly respondents were <60 years old (66.3%), male (71.9%), less than high school educational (68.5%), not working (69.7%), lower income (55.1%), having an ESRD duration of <3 years (67.4%), taking ≤6 item medicines (96.6%), having a mean (±SD) QOL-based on a utility value of 0.779±0.172 and a visual analog scale (VAS) of 60.79±18.04. Hence, there was no significant correlation between MA and QOL, as well as patient characteristics to MA (p>0.05).). Otherwise, patients aged <60 years, high levels of education and income, as well as the number of drug items received, tend to have a better QOL (p<0.05).


Keywords


Gagal ginjal kronik; hemodialisis; hipertensi; kepatuhan; kualitas hidup

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References

Abbafati C, Machado DB, Cislaghi B, Salman OM, Karanikolos M, McKee M, et al. Global Burden of 369 Diseases And Injuries in 204 Countries And Territories, 1990–2019: A Systematic Analysis For The Global Burden of Disease Study 2019. The Lancet. 2020;396:1204–1222.

National Kidney Foundation. Volume 2: End Stage Renal Disease. Am J Kidney Dis. 2021;77(4):S183-S598.

Kementerian Kesehatan Republik Indonesia. Laporan Nasional Riset Kesehatan Dasar 2018. Kementerian Kesehatan RI. Published online. 2018:174.

Luque A, Montenegro AJN, Aurioles EM, Sanchez JCC, Toro MCT, Gonzales J A, et al. Medication-Related Factors Associated With Health-Related Quality Of Life In Patients Older Than 65 Years With Polypharmacy. PloS ONE. 2017;12(2):1–16.

Perhimpunan Nefrologi Indonesia. 11th Report of Indonesian Renal Registry 2018. Pernefri. 2018;1–46.

Colvy J. Gagal Ginjal Tips Cerdas Mengenali dan Mencegah Gagal Ginjal. DAFA Publishing, Yogyakarta, Indonesia. 2010, dalam Rahayu F, Fernandoz T, Ramlis R. Hubungan Frekuensi Hemodialisis dengan Tingkat Stres pada Pasien Gagal Ginjal Kronik yang Menjalani Hemodialisis. J Keperawatan Silampari. 2018;1(2):139-153.

Manguma C, Kapantow GHM, Joseph WBS. Faktor-Faktor Yang Berhubungan Dengan Kepatuhan Pasien GGK. Universitas Sam Ratulangi. 2014, dalam Kusniawati K. Hubungan Kepatuhan Menjalani Hemodialisis Dan Dukungan Keluarga Dengan Kualitas Hidup Pasien Gagal Ginjal Kronik Di Ruang Hemodialisa Rumah Sakit Umum Kabupaten Tanggerang. J Med (Media Inf Kesehatan. 2018;5(2):206-233.

Roy L, White-Guay B, Dorais M, Dragomir A, Lessard M, Perreault S. Adherence To Antihypertensive Agents Improves Risk Reduction Of End-Stage Renal Disease. Kidney International. 2013;84(3):570–577.

Kusniawati K. Hubungan Kepatuhan Menjalani Hemodialisis Dan Dukungan Keluarga Dengan Kualitas Hidup Pasien Gagal Ginjal Kronik Di Ruang Hemodialisa Rumah Sakit Umum Kabupaten Tangerang. J Med (Media Inf Kesehatan). 2018;5(2):206-233.

Riyanto W. Hubungan antara Penambahan Berat Badan di antara Dua Waktu Hemodialisis terhadap Kualitas Hidup Pasien PGK yang Menjalani Terapi Hemodialisis di Unit Hemodialisa RSUP Fatmawati Jakarta. 2010, dalam Hadi, SW. Hubungan Lama Menjalani Hemodialisis dengan Kepatuhan Pembatasan Asupan Cairan pada Pasien GGK di RS PKU Muhammadiyah Unit II Yogyakarta. Igarss. 2014;1:1–5.

Sari A, Lestari NY, Perwitasari DA. Validasi ST European Quality of Life-5 Dimensions (EQ-5D) Versi Indonesia Pada Pasien Hipertensi di Puskesmas Kota Gede II Yogyakarta. Pharmaciana. 2015;5(2):131-138.

Mukakarangwa MC, Chironda G, Bhengu B, Katende G. Adherence to Hemodialysis and Associated Factors among End Stage Renal Disease Patients at Selected Nephrology Units in Rwanda: A Descriptive Cross-Sectional Study. Nursing Research and Practice. 2018;2018:1–8.

Kim Y, Evangelista LS, Philips LR, Pavlish C, Kopple JD. The End-Stage Renal Disease Adherence Questionnaire (ESRDAQ): Testing The Psychometric Properties in Patients Receiving In-Center Hemodialysis. Nephrol Nurs J. 2010; 37(4):377–393.

Waas T, Schulz A, Lotz J, et al. Distribution of estimated glomerular filtration rate and determinants of its age dependent loss in a German population-based study. Sci Rep. 2021;11(1):10165.

Weinstein JR, Anderson S. The Aging Kidney: Physiological Changes. Advances in Chronic Kidney Disease. 2010;17(4):302-307.

Isroin L, Y I, Soejono S. Manajemen Cairan pada Pasien Hemodialisis Untuk Meningkatkan Kualitas Hidup di RSUD Dr. Harjono Ponorogo. IJNP (Indonesian J Nurs Pract. 2014;1(2):146-156.

Hu D, Juarez DT, Yeboah, M, Castillo TP. Interventions to increase medication adherence in African-American and Latino populations: a literature review. Hawai’i Journal of Medicine & Public Health : A Journal of Asia Pacific Medicine & Public Health. 2014;73(1):11–8.

Lachaine J, Yen L, Beauchemin C, Hodgkins P. Medication Adherence And Persistence In The Treatment Of Canadian Ulcerative Colitis Patients: Analyses With The RAMQ Database. BMC Gastroenterology. 2013;13(1):1–8, dalam Edi I GMS. Faktor-Faktor Yang Mempengaruhi Kepatuhan Pasien Pada Pengobatan. J Ilmiah Medicamento. 2020;1(1):1–8.

Safnurbaiti DP, Andayani TM, Irijanto F. Analisis Biaya Dan Nilai Utilitas Pasien Hemodialisa Yang Diberikan Terapi Sevelamer Karbonat. Oceana Biomedicina Journal. 2018;1(2):79–89.

Surendra NK, Manaf MRA, Hooi LS, Bavandan S, Nor FSM, Khan SSF, et al. Health Related Quality Of Life Of Dialysis Patients In Malaysia: Haemodialysis Versus Continuous Ambulatory Peritoneal Dialysis. BMC Nephrology. 2019;20: 151-160.

Nurani VM, Mariyanti S. Gambaran Makna Hidup Pasien Gagal Ginjal Kronik Yang Menjalani Hemodialisa. J Psikol. 2013;11(1):1-13.

Purba FD, Hunfeld JAM, Iskandarsyah A, et al. The Indonesian EQ-5D-5L Value Set. PharmacoEconomics. 2017;35(11):1153-1165.

Karuniawati E, Supadmi W. Kepatuhan Penggunaan Obat dan Kualitas Hidup Pasien Hemodialisa di RS PKU Muhammadiyah Yogyakarta Periode Maret 2015. J Farm Sains dan Komunitas. 2016;13(2):73-80.

Puspasari S, Nggobe IW. Hubungan Kepatuhan Menjalani Terapi Hemodialisa Dengan Kualitas Hidup Pasien Di Unit Hemodialisa RSUD Cibabat-Cimahi. Holistik Jurnal Kesehatan. 2018;12(3):154–159.

Alfarisi AM. Hubungan Antara Kepatuhan Menjalani Hemodialisa Dengan Kualitas Hidup Pasien Chronik Kidney Disease (CKD) Di Rumah Sakit Umum Daerah Pandan Arang Boyolali. Universitas Muhammadiyah Surakarta. 2019;1-13.

Handayani RS, Rahmayati E. Faktor-faktor yang Berhubungan dengan Kualitas Hidup Pasien Chronic Kidney Disease (CKD) yang Menjalani Hemodialisis. J Keperawatan. 2015;9(2):238–245.

Puspitasari CE, Andayani TM, Irijanto F. Penilaian Kualitas Hidup Pasien Hemodialisis Rutin dengan Anemia di Yogyakarta. J Manaj dan Pelayanan Farm. 2019;9(3):182-191.

Manavalan M, Majumdar A, Kumar KTH, Priyamvada PS. Assessment of health-related quality of life and its determinants in patients with chronic kidney disease. Indian J Nephrol. 2017;27(1):37-43.

Sarastika Y, Kisan K, Mendrofa O, Siahaan JV. Faktor-Faktor Yang Mempengaruhi Kualitas Hidup Pasien Gagal Ginjal Kronik (Ggk) Yang Menjalani Terapi Hemodialisa Di RSU Royal Prima Medan. J Ris Hesti Medan Akper Kesdam I/BB Medan. 2019;4(1):53-60.

Dejvorakul S, Kumar R, Srirojanakul S, Panupichit N, Somrongthong R. Factors predicted with quality of life among hemodialysis patients in private hospital of Thailand. Hospital Practice. 2019;47(5):254-258.

De Brincat M. Medication adherence : patient education , communication and behaviour. J Malta Coll Pharm Pract. 2012;(18):3-5.

Winata LCWP, Putranto W, Fanani M. Association between Hemodialysis Adequacy, Family Support, and Quality of Life in Chronic Renal Failure Patients. Indones J Med. 2017;2(1):63-72.



DOI: https://doi.org/10.22146/jmpf.69974

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