* Corresponding Author
Analisis Kualitas Hidup Pasien Diabetes Melitus Tipe 2 Berdasarkan Pola Peresepan Antidiabetik dan Komplikasi
https://doi.org/10.22146/jmpf.45862 Pande Made Desy Ratnasari(1*), Tri Murti Andayani(2), Dwi Endarti(3)
(1) Magister Farmasi Klinik, Fakultas Farmasi, Universitas Gadjah Mada,Yogyakarta
(2) Fakultas Farmasi, Universitas Gadjah Mada,Yogyakarta
(3) Fakultas Farmasi, Universitas Gadjah Mada,Yogyakarta
(*) Corresponding Author
Abstract
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease that requires lifelong therapy to control blood glucose. The long term use and different mechanism of action antidiabetic have the potential cause side effects and discomfort that affects the quality of life. This study aimed to determine differences in the quality of life of patients with T2DM based on antidiabetic prescribed and complications at the Outpatient of Panembahan Senopati Bantul Yogyakarta Hospital in September 2017. This research is observational with a cross-sectional design. Quality of life data is taking concurrently using the Diabetes Quality of Life Clinical Trial Questionnaire and patient's medical record. This study involved 200 T2DM patients who received antidiabetic at least 3 months before study, aged ≥18 years and agreed to inform concent. Sociodemographic data, antidiabetic prescribed and complications were described descriptively. Differences in the quality of life based on antidiabetic prescribed and complications using the Kruskal Wallis test which was further analyzed using the post hoc by Mann Whitney test. The results showed the majority of patients received oral combination with insulin (48.5%) and dominated by macrovascular complications (19.5%). The average value of patient's quality of life is 65.7. There was difference quality of life based on antidiabetic prescribed in the domain of treatment satisfaction (p=0.000) between oral monotherapy with combination of oral and insulin (p=0.000) and insulin monotherapy with combination of oral and insulin (p=0.002). There were differences in quality of life based on complications in the mental health domain (p=0.003) between macrovascular and microvascular (p=0.011) and between microvascular and without complications (p=0.001).
Keywords
Full Text:
PDFReferences
1. Gregg EW. The Changing Tides of the Type 2 Diabetes Epidemic d Smooth Sailing or Troubled Waters Ahead ? Kelly West Award Lecture 2016. Diabetes Care. 2017;40:1289-1297.
2. Ogurtsova K, Rocha JD, Huang Y, Linnenkamp U, Guariguata L. IDF Diabetes Atlas : Global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract. 2017;128:40-50.
3. Inzucchi SE, Bergenstal RM, Buse JB, et al. Management of Hyperglycemia in Type 2 Diabetes, 2015: A Patient-Centered Approach: Update to a Position Statement of the American Diabetes Association and the European Association for the Study of Diabetes. Diabetes Care. 2015;38(1):140-149.
4. Davies MJ, Alessio DAD, Fradkin J, Kernan WN, Mathieu C. Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetologia. 2018.
5. American Diabetes Association. Standar of Medical Care in Diabetes-2018. Clin Diabetes. 2018;36(1):14-37.
6. Hayek AA Al, Robert AA, Saeed A Al, Alzaid AA, Sabaan FS Al. Factors Associated with Health-Related Quality of Life among Saudi Patients with Type 2 Diabetes Mellitus : A Cross-Sectional Survey. Diabetes Metab J. 2014;38:220-229.
7. Perwitasari DA, Adikusuma W, Rikifani S, Supadmi W. Quality of Life and Adherence of Diabetic Patients in Different Treatment Regimens Kualitas Hidup dan Kepatuhan Pasien Diabetes Melitus dengan Pengobatan yang Berbeda. Indones J Clin Pharm. 2014;3(4):107-113.
8. Goudswaard A, Furlong N, Rutten G, Stolk R, Valk G. Review : Insulin monotherapy and insulin combined with oral hypoglycemic agents provide similar glycemic control Review : Short-acting insulin analogues reduce glycosylated hemoglobin more than regular human insulin but only in adults with type 1 diabetes. Cochrane Database Syst Rev. 2005;142(3):62-63.
9. Sepulveda E, Poínhos R, Pais-ribeiro J, Freitas P, Carvalho D. Health-related quality of life in type 1 and type 2 diabetic patients in a Portuguese central public hospital. Diabetes Metab Syndr Obes. 2015;8:219-226.
10. Fatima M, Sadeeqa S, Ur S, Nazir R. Metformin and its gastrointestinal problems : A review . Biomed Res. 2018;29(11):2285-2289.
11. Gao X, Cai X, Yang W, Chen Y, Han X, Ji L. Meta-analysis and critical review on the ef fi cacy and safety of alpha-glucosidase inhibitors in Asian and non-Asian populations. J Diabetes Investig. 2018;9(2):321-331.
12. Yadav M, Saraswat N, Wal P, Rai A, Singh D. A Comparative Study of Drug Interaction and Side Effect of Drug for Treatment of Diabetes Mellitus: A Review. Int Res J Pharm. 2018;9(6):14-16.
13. Akinci F, Yildirim A, Go H. Assessment of health-related quality of life ( HRQoL ) of patients with type 2 diabetes in Turkey. Diabetes Res Clin Pract. 2008;79:117-123.
14. Chappidi M, Shivananjiah S, Thirthahalli C, et al. Complications of diabetes mellitus among patients attending the out- patient department of a tertiary care hospital. Int J Community Med Public Heal. 2018;5(1):341-348.
15. Liu Z, Fu C, Wang W, Xu B. Prevalence of chronic complications of type 2 diabetes mellitus in outpatients - a cross-sectional hospital based survey in urban China. Health Qual Life Outcomes. 2010;8(62):1-9.
16. Younis B Bin, Arshad R, Yousuf H, Salman F, Masood J, Khurshid S. Impact of type 2 diabetes mellitus on quality of life in people with diabetes presenting to a specialist diabetes clinic. Turkish J Med Sci. 2017;47:123-126.
17. Andayani TM. Health-Related Quality of Life of Type 2 Diabetes Mellitus Outpatients at Dr . Sardjito Hospital , Yogyakarta , Indonesia : An Insulin-Based Therapy Approach Kualitas Hidup Terkait Kesehatan dari Pasien Diabetes Melitus Tipe 2 di Rumah Sakit Umum Pusat Dr. Indones J Clin Pharm. 2017;6(4):231-239.
18. Prajapati VB, Blake R, Acharya LD, Seshadri S. Assessment of quality of life in type II diabetic patients using the modified diabetes quality of life (MDQoL)-17 questionnaire. Brazilian J Pharm Sci. 2015;53(4):1-9.
19. Habib M, Pathik B, Maryam H. Research Methodology - Contemporary Practices: Guidelines for Academic Researchers. Cambridge Scholars Publishing; 2014.
20. Shen W, Kotsanos JG, Huster WJ, Mathias SD, Andrejasich CM, Patrick DL. Development and validation of the diabetes quality of life clinical trial questionnaire. Med Care. 1999;37(4):45-66.
21. Hartati T. Kualitas Hidup Penderita DM Tipe 2: Perbandingan Antara Penderita Kadar Gula Darah Terkendali dan Tidak Terkendali [tesis]. 2003.
22. Lu Y, Wang N, Chen Y, et al. Health-related quality of life in type-2 diabetes patients : a cross-sectional study in East China. BMC Endocr Disord. 2017;17(38):1-7.
23. Hestiana D. Jurnal of Health Education. J Heal Educ. 2017;2(2):138-145.
24. Harreiter J, Kautzky-willer A, Kautzky-willer A. Sex and Gender Differences in Prevention of Type 2 Diabetes. Front Endocrinol (Lausanne). 2018;9(5):1-15.
25. Nishtar S. Diabetes is a serious women’s health issue. Diabetes Voice. 2017;64(3):4-5.
26. Lascar N, Brown J, Pattison H, Barnett AH, Bailey CJ, Bellary S. Type 2 diabetes in adolescents and young adults. LANCET Diabetes Endocrinol. 2018;6(1):69-80.
27. Nandimath V, Swamy C, Nandimath S, Jatti G, Jadhav S. Evaluation of certain risk factors of type 2 diabetes mellitus : a case control study. Int J Med Sci Public Heal. 2016;5(7):3-8.
28. Al-saeed AH, Constantino MI, Molyneaux L, et al. An Inverse Relationship Between Age of Type 2 Diabetes Onset and Complication Risk and Mortality : The Impact of Youth Onset Type 2 Diabetes. Diabetes Care. 2016:1-7.
29. Song Y, Liu X, Zhu X, et al. Increasing trend of diabetes combined with hypertension or hypercholesterolemia : NHANES data analysis 1999-2012. Sci Rep. 2016;6(1):1-9.
30. Kassahun T, Gesesew H, Mwanri L, Eshetie T. Diabetes related knowledge, self-care behaviours and adherence to medications among diabetic patients in Southwest Ethiopia: a cross-sectional survey. BMC Endocr Disord. 2016;16(1):1-11.
31. Isnaini N, Ratnasari. Faktor risiko mempengaruhi kejadian Diabetes mellitus tipe dua Risk factors was affects of diabetes mellitus type 2. J Keperawatan dan Kebidanan Aisyiyah. 2018;14(1):59-68.
32. Falco G, Pirro P, Castellano E, M A, Borretta G, Gianotti L. The Relationship between Stress and Diabetes Mellitus. J Neurol Psychol. 2015;3(1):1-7.
33. Faridah IN, Dewintasari V. Quality of Life Analysis In Diabetes Mellitus Type 2 Patients Using Monotherapy and Combination Treatment of Medicine. Indones J Pharm. 2017;28(2):119.
34. Prachi D, Chirag D, Aarti P, Desai S. A Drug Prescribing Pattern Study in Diabetes Mellitus : An Outpatient Study. J Pharm Sci Biosci Res. 2015;5(1):115-118.
35. Rani J, Reddy S. Prescribing pattern of antidiabetic drugs in urban population of Hyderabad. Natl J Physiol Pharm Pharmacol. 2015;5(1):5.
36. Soelistijo S, Novida H, Rudijanto A, Soewondo P, Suastika K, Manaf A. Konsensus Pengelolaan Dan Pencegahan Diabetes Melitus Tipe 2 Di Indonesia 2015. Pengurus Besar Perkumpulan Endokrinologi Indonesia (PB PERKENI); 2015.
37. Siddiqui MA, Ul A, Siddiqui H, Rwelly F, Clay A. Frequency of diabetes , complications and vascular risk factors in male and female population of Al-Jouf , Saudi Arabia. Int J Med Dev Ctries. 2018;2(1):27-32.
38. Kim JH, Kim DJ, Jang HC, Choi SH. Epidemiology of Micro- and Macrovascular Complications of Type 2 Diabetes in Korea. Diabetes Metab J. 2011;35:571-577.
39. Rhee SY, Chon S, Kwon MK, et al. Prevalence of Chronic Complications in Korean Patients with Type 2 Diabetes Mellitus Based on the Korean National Diabetes Program. Diabetes Metab J. 2011;35(5):504.
40. Andayani TRIM, Izham M, Ibrahim M, Asdie AH. International Journal of Pharmacy and Pharmaceutical Sciences. 2010:139-145.
41. Maniarasu K, Muthunarayanan L. Prevalence of Certain Chronic Complications of Diabetes among Type 2 Diabetic Patients in Rural Population of Kancheepuram District, Tamil Nadu-A Cross Sectional Study. Int J Med Public Heal. 2017;7(1):41-46.
42. Zhuo X, Zhang P, Hoerger TJ. Lifetime Direct Medical Costs of Treating Type 2 Diabetes and Diabetic Complications. Am J Prev Med. 2013;45(3):253-261.
43. Selim S, Abougalambou I, Hassali MA, Azhar S, Sulaiman S, Abougalambou AS. Prevalence of Vascular Complications among Type 2 Diabetes Mellitus Outpatients at Teaching Hospital in Malaysia. J Diabetes Metab. 2011;2(1):2-5.
44. Jung HS. Review Article Clinical Implications of Glucose Variability : Chronic Complications of Diabetes. Endocrinol Metab. 2015;30:167-174.
45. Group UPDS (UKPDS). Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352(9131):837–853.
46. Sari R, Thobari J, Andayani T. Evaluasi Kualitas Hidup Pasien Diabetes Melitus Tipe 2 yang diterapi Rawat Jalan dengan Anti Diabetik Oral Di Rsup Dr. Sardjito. J Manaj dan Pelayanan Farm. 2011;1(1):35-42.
47. Adikusuma W, Perwitasari D, Supadmi W. Pengukuran Kualitas Hidup Pasien Diabetes Melitus Tipe 2 yang Mendapat Antidiabetik Oral Di Rumah Sakit PKU Muhammadiyah Bantul Yogyakarta. J Ilm Ibnu Sina. 2016;1(1):1-8.
48. Lau ANC, Tang T, Pharmd HH, Thorpe K, Mhsc CHYY. Initiating insulin in patients with type 2 diabetes. Can Med Assoc J. 2012;184(7):767-776.
49. Owens DR. Clinical Evidence for the Earlier Initiation of Insulin Therapy in Type 2 Diabetes. Diabetes Technol Ther. 2013;15(9):776-785.
50. Nasralla Saleh MS, Alwahedi Z. Quality of Life Predictors and Glycemic Control among Type 2 Diabetic Patients Attending Primary Health Care Centers in Qatar. Prim Heal Care Open Access. 2016;6(2):1-5.
51. Kiadaliri AA, Najafi B, Mirmalek-Sani M. Quality of life in people with diabetes: a systematic review of studies in Iran. J Diabetes Metab Disord. 2013;12(1):54.
52. Lyrakos G, Hatziagelaki2 E, Damigos D, Papazafiropoulou A, Bousboulas S, Batistaki C. Predictors of health-related quality of life in Diabetic Neuropathy type II diabetic patients in Greece. Heal Sci J. 2013;7(3):327-341.
53. Al-Shehri FS. Quality of Life among Saudi Diabetics. J Diabetes Mellit. 2014;4(3):225-231.
54. Lindsay G, Inverarity K, McDowell JRS. Quality of Life in People with Type 2 Diabetes in Relation to Deprivation, Gender, and Age in a New Community-Based Model of Care. Nurs Res Pract. 2011;2011:1-8.
55. Redekop W, Koopmanschap M, Stolk R, Rutten G, Niessen L. Health-Related Quality of Life and Treatment Satisfaction in Dutch Patients With Type 2 Diabetes. Diabetes Care. 2002;25(3):458-463.
56. Claudia A, Maia CDO, Braga ADA, et al. Comorbidity of Depression and Anxiety : Association with Poor Quality of Life in Type 1 and 2 Diabetic Patients. Clin Pract Epidemiol Ment Heal. 2013;9:136-141.
DOI: https://doi.org/10.22146/jmpf.45862
Article Metrics
Abstract views : 12727
| 
views : 14738
Refbacks
- There are currently no refbacks.
Copyright (c) 2019 JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice)
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
