Evaluation of Compounding Sterile Preparations for Hospitalized Pediatric Patients in "X" Hospital Semarang City, Indonesia

https://doi.org/10.22146/jmpf.34783

Melviya Sudianto(1), Dina Christin Ayuningputri(2), Sri Hartati Yuliani(3*)

(1) Sanata Dharma University
(2) Sanata Dharma University
(3) Sanata Dharma University
(*) Corresponding Author

Abstract


Compounding sterile preparation, especially for hospitalized pediatric patients, needs more concern due to dose adjustment. Things to be concerned about are compounding personnel, utilization of aseptic technique, and facilitation that affects the quality of sterile preparations. The aims of this study were to observe compounding process and to quality the sterile preparations for hospitalized pediatric patients in “X” Hospital, Semarang City, Indonesia. This research is an observational analitic with incidentally sampling research. Subject in this research was personnel who performed sterile preparations for hospitalized pediatric patients. Results from 114 sterile preparations which were observed in pediatric ward showed that compounding personnel (100%), facilities & infrastuctures, and sterile preparations procedure were not suitable with the Mixing Guideline for injectable drug and cytostatic (2009), hence it could impact the quality of sterile preparations. In addition, even after implementing appropriate solvent, compounding procedures, and aseptic technique had been utilized (100%), the physical incompatibility occurred was 8.77%. The pH of Ceftriaxone and Cefotaxime was similar with those in the literature, but for Omeprazole’s pH and based on sterility test, there were no bacterial growth.

Keywords


Sediaan steril, pediatri, inkompatibilitas, stabilitas

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References

  1. Pedersen CA, Schneider PJ, Scheckelhoff DJ. ASHP national survey of pharmacy practice in hospital settings: Dispensing and administration - 2014. Am J Heal Pharm. 2015;72(13):1119-1137. doi:10.2146/ajhp150032
  2. Khalili H, Sheikhbabayi M, Samadi N, Jamalifar H, Dalili D, Samadi N. Bacterial contamination of single-and multiple-dose vials after multiple use and intravenous admixtures in three different hospitals in Iran. Iran J Pharm Res. 2013;12(1):205-209.
  3. Rich D, Fricker Jr M, Cohen M, Levine S. Guidelines for the Safe Preparation of Sterile Compounds: Results of the ISMP Sterile Preparation Compounding Safety Summit of October 2011. Hosp Pharm. 2013;48(4):282-294. doi:10.1310/hpj4804-282
  4. Surahman E, Mandalas E, Kardinah EI. Evaluasi Penggunaan Sediaan Farmasi Intravena untuk Penyakit Infeksi pada Salah Satu Rumah Sakit Swasta di Kota Bandung. Pharm Sci Res. 2012;5(1):21-39. http://psr.ui.ac.id/index.php/journal/article/view/3416%0Ahttp://psr.ui.ac.id/index.php/journal/article/download/3416/494.
  5. Pandini IP. Profil Pencampuran Sediaan Steril Injeksi di Rumah Sakit Umum Daerah Cilacap Tahun 2016,. Univ Muhammadiyah Purwokerto. 2016.
  6. Lucida H, Armal K, Harefa, et al. Prosiding Seminar Nasional dan Workshop “Perkembangan Ter kini Sains Farmasi dan Kl inik IV” tahun 2014. 2014:220-227.
  7. Maharani L, Astuti A, Achmad A. Parenteral Admixture Compatibility in Neurosurgery Ward in Prof. Dr. Margono Soekarjo Regional Public Hospital. Indones J Clin Pharm. 2014;3(1):1-9. doi:10.15416/ijcp.2014.3.1.1
  8. Menteri Kesehatan RI. Peraturan Menteri Kesehatan Nomor 72 Tahun 2016 Tentang Standar Pelayanan Kefarmasian Di Rumah Sakit.; 2016.
  9. Costa LA, Valli C, Alvarenga AP. Medication dispensing errors at a public pediatric hospital. Rev Lat Am Enfermagem. 2008;16(5):812-817. doi:10.1590/S0104-11692008000500003
  10. Taxis K, Barber N. Causes of intravenous medication errors - Observation of nurses in a German hospital. J Public Health (Bangkok). 2004;12(2):132-138. doi:10.1007/s10389-004-0019-4
  11. Allegaert K, Anderson B, Vrancken M. Impact of a paediatric vial on the magnitude of systematic medication errors in neonates. Paediatr Perinat Drug Ther. 2006;7:59–63.
  12. Gorski LA, Hagle ME, Bierman S. Intermittently Delivered IV Medication and pH: Reevaluating the Evidence. J Infus Nurs. 2015;38(1):27-46. doi:10.1097/NAN.0000000000000081
  13. Staven V, Wang S, Grønlie I, Tho I. Development and evaluation of a test program for Y-site compatibility testing of total parenteral nutrition and intravenous drugs. Nutr J. 2016;15(1):1-18. doi:10.1186/s12937-016-0149-x
  14. Bülbül A, Kunt A, Selalmaz M, Sözeri Ş, Uslu S, Nuhoğlu A. Assessment of knowledge of pediatric nurses related with drug administration and preparation. Turk Pediatr Ars. 2014;49(4):333-339. doi:10.5152/tpa.2014.1751
  15. Austin P, Elia M. A systematic review and meta-analysis of the risk of microbial contamination of aseptically prepared doses in different environments. J Pharm Pharm Sci. 2009;12(2):233-242. doi:10.18433/J3JP4B
  16. Depkes RI. Pedoman Pencampuran Obat Suntik dan Penggunaan Sediaan Sitostatika. 2009:1-57.
  17. Chedoe I, Molendijk HA, Dittrich STAM, et al. Incidence and Nature of Medication Errors in Neonatal Intensive Care with Strategies to Improve Safety. Drug Saf. 2007;30(6):503-513. doi:10.2165/00002018-200730060-00004
  18. Lukas S. Formulasi Steril,. 2011. CV Andi Offset, Yogayakarta, pp45-46
  19. Buchanan EC, Schneider PJ. Peracikan Sediaan Steril, Ed.2,. Vol 2.; 2009. diterjemahkan oleh: Amalia H. Hadinata dan July Manurung, Penerbit Buku Kedokteran EGC, Jakarta, pp. 20, 78-79.
  20. Perz JF, Thompson ND, Schaefer MK, Patel PR. US Outbreak Investigations Highlight the Need for Safe Injection Practices and Basic Infection Control. Clin Liver Dis. 2010;14(1):137-151. doi:10.1016/j.cld.2009.11.004
  21. Nagaraju, A., Deepak, A,S., Aruna, C., Swathi, K., Reddy, P., Devi, S., & Purushothaman, M. Assessment Of Intravenous Admixtures Incompatibilities & The Incidence Of Intravenous Drug Administration Errors. World J Pharm Pharm Sci. 2015;4(8):1227-1237.
  22. Ong WM, Subasyini S. Medication errors in intravenous drug preparation and administration. Med J Malaysia. 2013;68(1):52-57. doi:10.4172/2167-1168.1000285
  23. Trissel LA. Handbook on Injectable Drugs Ed 16th.; 2011. American Society of Health System Pharmacists.
  24. Gray A, Wright J, Goodey V, Bruce L. Injectable Drugs Guide.; 2011. Pharmaceutical Press, London, pp. 136-137, 127-129, 617-619.
  25. Newton DW. Drug incompatibility chemistry. Am J Heal Pharm. 2009;66(4):348-357. doi:10.2146/ajhp080059
  26. Allen L V. Handbook of Pharmaceutical Excipients, Sixth Edition.; 2009. London, Pharmaceutical Press and American Pharmacists Assosiation, p. 181.



DOI: https://doi.org/10.22146/jmpf.34783

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