Drug Interaction Potency on Type 2 Diabetes Mellitus Patient in Hospital X in South Tangerang

https://doi.org/10.22146/jmpf.34027

Yardi Saibi(1*), Delina Hasan(2), Verona Shaqila(3)

(1) Study Program of Pharmacy, Syarif Hidayatullah State Islamic University Jakarta
(2) Study Program of Pharmacy, Syarif Hidayatullah State Islamic University Jakarta
(3) Study Program of Pharmacy, Syarif Hidayatullah State Islamic University Jakarta
(*) Corresponding Author

Abstract


Drug interaction is an interaction among a drug with other ingredients that prevents the drug from giving certain or expected effect. Such interaction might happen between a drug and other drugs, drugs with food, as well as drugs and disease. Potential drug interaction in patients with type 2 diabetes mellitus in some hospitals had been reported by several previous publications. This study aimed to identify the potential of drug interactions in patients with type 2 diabetes mellitus at Hospital X, South Tangerang. This paper is a descriptive research with retrospective retrieval data. Data were obtained in the form of patient medical records from July 2014 to June 2015. Data analysis was done by descriptive statistic analysis using SPSS version 16. The results showed that there were 90 medical records that fulfilled the inclusion criteria. Of these, 57.7% was found to be potential drug interaction. There are 55 drug interactions that potentially cause hypoglycemia, and there are 21 times that potentially cause hyperglycemia. The severity of interaction in moderate category was 89.39% (total of 66), and the rest was in minor category. Major categories were not found. The potential for drug interactions in type 2 diabetes mellitus patients is quite common and these findings complement the findings of previous published studies. Physicians and pharmacists as health workers who are directly related to the treatment of patients need to increase awareness of the potency of interactions of these drugs.

Keywords


interaksi obat, obat antidiabets, diabetes melitus tipe 2,hipoglikemia, hiperglikemia

Full Text:

PDF


References

  1. Omudhome Ogbru P. Drug Interactions. https://www.rxlist.com/drug-interaction-checker.htm. Accessed March 17, 2018.
  2. Tatro DS. Drug Interaction Facts. 5th ed. Lippincott Williams & Wilkins; 2014.
  3. Guthrie B, Makubate B, Hernandez-Santiago V, Dreischulte T. The rising tide of polypharmacy and drug-drug interactions: population database analysis 1995-2010. BMC Med. 2015;13:74. doi:10.1186/s12916-015-0322-7.
  4. Salwe KJ, Kalyansundaram D, Bahurupi Y. A study on polypharmacy and potential drug-drug interactions among elderly patients admitted in department of medicine of a tertiary care hospital in puducherry. J Clin Diagnostic Res. 2016;10(2):FC06-FC10. doi:10.7860/JCDR/2016/16284.7273.
  5. D GGP. Potential drug-drug interactions among hospitalized patients in a developing country. 2017;8(3):282-288. doi:10.22088/cjim.8.4.282.
  6. May M. Clinically and pharmacologically relevant interactions of antidiabetic drugs. Ther Adv Endocrinol Metab. 2016;7(2):69-83. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4821002/#!po=1.85185.
  7. Talbert RL, Dipiro JT. Pharmacotherapy A Pathophysiologic Approach 9/E By Robert L. Talbert, Joseph T. DiPiro. New york: The McGraw-Hill Companies Inc
  8. Yuniar CT, Sukandar EY, Lisni I, Pembahasan H. Identifikasi Drug Therapy Problems (DTPs) Pada Pasien Diabetes Melitus Tipe 2 Rawat Jalan di Salah Satu RS Swasta di Bandung. 2012;XXXVII(2):59-63.
  9. Lira CP, Lolo WA, Wewengkang DS. POTENSI DRUG RELATED PROBLEMS ( DRPS ) PENGGUNAAN OBAT ANTIDIABETES PADA PASIEN DIABETES MELITUS TIPE 2 DI INSTALASI RAWAT INAP RUMAH SAKIT KALOORAN GMIM AMURANG. 2017;6(4).
  10. Farmasi D, Universitas F. Analisis Interaksi Obat Antidiabetik Oral Pada Pasien Rawat Jalan Di Rumah Sakit X Depok. 2008;4(1):8-14.
  11. Meryta A, Efrilia M, Panca P, Chandra B. Gambaran Interaksi Obat Hipoglikemik Oral (Oho) Dengan Obat Lain Pada Pasien Diabetes Melitus (Dm) Tipe Ii Di Apotek Imphi Periode Oktober 2014 Sampai Maret 2015. 2015;1(2):193-199.
  12. Arifin uce lestari; desi meliyani; helmi. Kajian Interaksi Obat pada Pasien Diabetes Mellitus Tipe 2 dengan Hiperlipidemia di RSUD Raden Mattaher Jambi ( Study of Drug Interaction on Type 2 Diabetes Mellitus - Hyperlipidemia Patient in. In: ; 2015:6-7.
  13. Fallis A. penanganan kejadian interaksi obat pada pasien DM tipe 2 dan mencegah kejadian interaksi obat yang tidak diinginkan. J Chem Inf Model. 2013;53(9):1689-1699. doi:10.1017/CBO9781107415324.004.
  14. Zaman Huri H, Chai Ling L. Drug-related problems in type 2 diabetes mellitus patients with dyslipidemia. BMC Public Health. 2013;13(1). doi:10.1186/1471-2458-13-1192.
  15. May M, Schindler C. Clinically and pharmacologically relevant interactions of antidiabetic drugs. Ther Adv Endocrinol Metab. 2016;7(2):69-83. doi:10.1177/2042018816638050.
  16. Sankar V, Saaed Y, Joseph R, Azizi H, Thomas P. Serious Drug-Drug Interactions in the Prescriptions of Diabetic Patients. Med Sci. 2015;3(4):93-103. doi:10.3390/medsci3040093.
  17. micromedex. Drug Interactions. http://www.micromedexsolutions.com/micromedex2/4.34.0/WebHelp/Tools/Interactions/Drug_Interactions_severity_definitions.htm. Published 2013. Accessed March 18, 2018.



DOI: https://doi.org/10.22146/jmpf.34027

Article Metrics

Abstract views : 7190 | views : 39171

Refbacks

  • There are currently no refbacks.


Copyright (c) 2018 JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice)

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Jurnal Manajemen dan Pelayanan Farmasi
Faculty of Pharmacy
Universitas Gadjah Mada
Creative Commons License
View My Stats