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Stres, Kecemasan dan Kadar Kortisol Serum Wanita dengan Sindrom Ovarium Polikistik (SOPK)
https://doi.org/10.22146/jkr.72468 Erna Yovi Kurniawati(1*), Suharyo Hadisaputro(2), Agus Suwandono(3)
(1) Politeknik Kesehatan Ummi Khasanah
(2) Politeknik Kesehatan Kemnkes Semarang
(3) Universitas Diponegoro
(*) Corresponding Author
Abstract
Latar Belakang: SOPK dikaitkan dengan risiko kesehatan mental jangka panjang seperti disfungsi seksual, gangguan kesehatan, gangguan mood, kecemasan, dan depresi. Kadar kortisol mempengaruhi fungsi endokrin lain dalam tubuh dan dapat mempengaruhi resistensi insulin dan anovulasi.
Tujuan: Mengetahui tingkat stress, tingkat kecemasan dan kadar kortisol serum wanita dengan sindrom ovarium polikistik (SOPK)
Metode: Penelitian deskriptif, metode sampel pusposive sampling dengan jumlah responden 30 wanita dengan sindrom ovarium polikistik di Yogyakarta. Instrumentasi menggunakan Kuesioner State Anxiety dan Trait Anxiety (STAI), Perceived Stress Scale-10 (PSS-10), dan Kadar kortisol serum dengan ELISA di LPPT UGM.
Hasil dan Pembahasan: Seluruh responden mengalami kecemasan, sebesar 53% responden mengalami kecemasan berat, dan seluruh responden mengalami tingkat stress berat. Rerata kadar kortisol serum 124.98 mcg/dl.
Kesimpulan: Faktor psikologis sebagai indikator psikologis yang perlu dicegah atau dikelola saat merawat SOPK. Kombinasi terapi fisik dan psikoterapi atau mindfulness diperlukan untuk efektivitas terapi yang optimal.
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1. Wahyuni A, Kusumawati W, Sedah Kirana K, Dwi Mayayus-tika C, Kedokteran dan Kesehatan Indonesia J. Family history of PCOS, obesity, low fiber diet, and low physical activity increase the risk of PCOS. JKKI : Jurnal Kedokteran dan Kesehatan Indonesia [Internet]. 2022 May 31 [cited 2023 Jun 22]; Available from: https://journal.uii.ac.id/JKKI/article/view/20990
2. Hoeger KM, Dokras A, Piltonen T. Update on PCOS: Consequences, Challenges, and Guiding Treatment. Journal of Clinical Endocrinology and Metabolism. 2021 Mar 1;106(3):E1071–83.
3. Cheol JP. Risk Factors for Depression, Anxiety, and Stress in Patients with Polycystic Ovary Syndrome. Journal of the Korea Convergence Society [Internet]. 2022 [cited 2024 Jan 23];13(3):337–43. Available from: https://doi.org/10.15207/JKCS.2022.13.03.337
4. Li X, Cui T, Song X, Tian W, Lin Y, Zhang H. Comparison of health-related quality of life in different polycystic ovary syndrome phenotypes: A cross-sectional study. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2022 Apr 1;271:189–94.
5. Kurniawati EY, Hadisaputro S, Suwandono A. The Effect of Holistic Programs on Cortisol Serum Levels in Polycistic Ovarium Syndrome. Indonesian Journal of Medicine [Internet]. 2019 [cited 2023 Jul 11];4(4):376–82. Available from: https://doi.org/10.26911/theijmed.2019.04.04.11
6. Muharam R, Purba JS, Hestiantoro A, Elvira SD. Profile on personality types and cortisol in polycystic ovarian syndrome. Middle East Fertil Soc J [Internet]. 2018 [cited 2023 Jun 30];23:189–94. Available from: https://doi.org/10.1016/j.mefs.2017.12.001
7. Benjamin JJ, Kuppusamy M, Koshy T, Kalburgi Narayana M, Ramaswamy P. Cortisol and polycystic ovarian syndrome–a systematic search and meta-analysis of case–control studies. Gynecological Endocrinology. 2021;37(11):961–7.
8. Dybciak P, Humeniuk E, Raczkiewicz D, Krakowiak J, Wdowiak A, Bojar I. Anxiety and Depression in Women with Polycystic Ovary Syndrome. Medicina 2022, Vol 58, Page 942 [Internet]. 2022 Jul 16 [cited 2024 Jan 23];58(7):942. Available from: https://www.mdpi.com/1648-9144/58/7/942/htm
9. Damone AL, Joham AE, Loxton D, Earnest A, Teede HJ, Moran LJ. Depression, anxiety and perceived stress in women with and without PCOS: a community-based study. Psychol Med [Internet]. 2019 Jul 1 [cited 2024 Jan 23];49(9):1510–20. Available from: https://www.cambridge.org/core/journals/psychological-medicine/article/abs/depression-anxiety-and-perceived-stress-in-women-with-and-without-pcos-a-communitybased-study/15A4D8B7B220768BC06639B4DAB98D72
10. Chen JY, Chin WY, Tiwari A, Wong J, Wong ICK, Worsley A, et al. Validation of the perceived stress scale (Pss-10) in medical and health sciences students in Hong Kong. Asia Pacific Scholar. 2021;6(2):31–7.
11. Correction to: The development of a six-item short-form of the state scale of the Spielberger State—Trait Anxiety Inventory (STAI) (British Journal of Clinical Psychology, (1992), 31, 3, (301-306), 10.1111/j.2044-8260.1992.tb00997.x). British Journal of Clinical Psychology. 2020 Jun 1;59(2):276.
12. Negdel T, Sengebaljir D, Munkhbayar B, Bilegsuren K, Ganbold A, Nanjid K, et al. Prevalence and Risk factors of Infertility in a Mongolian Population. Res Sq [Internet]. 2021 [cited 2023 Jun 25];1–17. Available from: https://doi.org/10.21203/rs.3.rs-26781/v3
13. Dobbie LJ, Pittam B, Zhao SS, Alam U, Hydes TJ, Barber TM, et al. Childhood, adolescent, and adulthood adiposity are associated with risk of PCOS: a Mendelian randomization study with meta-analysis. Hum Reprod [Internet]. 2023 Jun 1 [cited 2023 Jun 12];38(6):1168–82. Available from: http://www.ncbi.nlm.nih.gov/pubmed/37015099
14. Helvaci N, Okan Yildiz B. Polycystic ovary syndrome and aging: Health implications after menopause. Maturitas [Internet]. 2020 [cited 2023 Jun 30];139:12–9. Available from: https://doi.org/10.1016/j.maturitas.2020.05.013
15. Shaaban Z, Khoradmehr A, Jafarzadeh Shirazi MR, Tamadon A. Pathophysiological mechanisms of gonadotropins– and steroid hormones–related genes in etiology of polycystic ovary syndrome. Iran J Basic Med Sci [Internet]. 2019 Jan 1 [cited 2023 Jun 24];22(1):3. Available from: /pmc/articles/PMC6437453/
16. Teklemicheal AG, Kassa EM, Weldetensaye EK. Prevalence and correlates of infertility related psychological stress in women with infertility: a cross-sectional hospital based survey. BMC Psychol [Internet]. 2022 Dec 1 [cited 2024 Feb 16];10(1):1–8. Available from: https://bmcpsychology.biomedcentral.com/articles/10.1186/s40359-022-00804-w
17. Javed F, Ahmad M, Nasar Iqbal M. Resilience and Emotional Regulation Predicting Marital Satisfaction in Females Diagnosed with Polycystic Ovarian Syndrome (PCOS). Pak-Euro Journal of Medical and Life Sciences. 2022 Jun 30;5(2):391–8.
18. Surya Rakasiwi & Achmad Kautsar L, Keuangan KE. Pengaruh Faktor Demografi dan Sosial Ekonomi terhadap Status Kesehatan Individu di Indonesia. Kajian Ekonomi dan Keuangan [Internet]. 2021 Aug 24 [cited 2024 Feb 16];5(2):146–57. Available from: https://fiskal.kemenkeu.go.id/ejournal/index.php/kek/article/view/1008
19. Parker J, O’brien C, Hawrelak J, Gersh FL. Polycystic Ovary Syndrome: An Evolutionary Adaptation to Lifestyle and the Environment. International Journal of Environmental Research and Public Health 2022, Vol 19, Page 1336 [Internet]. 2022 Jan 25 [cited 2024 Jan 25];19(3):1336. Available from: https://www.mdpi.com/1660-4601/19/3/1336/htm
20. Sharma P, Kaur M, Kumar S, Khetarpal P. A cross-sectional study on prevalence of menstrual problems, lifestyle, mental health, and PCOS awareness among rural and urban population of Punjab, India. Journal of Psychosomatic Obstetrics & Gynecology [Internet]. 2022 [cited 2024 Jan 25];43(3):349–58. Available from: https://www.tandfonline.com/doi/abs/10.1080/0167482X.2021.1965983
21. Wang Y, Zhu Q, Dang X, He Y, Li X, Sun Y. Local effect of bisphenol A on the estradiol synthesis of ovarian granulosa cells from PCOS. https://doi.org/101080/0951359020161184641 [Internet]. 2016 Jan 2 [cited 2023 Jun 24];33(1):21–5. Available from: https://www.tandfonline.com/doi/abs/10.1080/09513590.2016.1184641
22. Guyansyah A, Wratsangka R, Dhanardono D, Ghazali MF, Edy HJ, Widyatama HG, et al. Primary infertility of male and female factors, polycystic ovary syndrome and oligoasthenoteratozoospermia dominate the infertile population in agricultural and industrial areas in Karawang Regency, West Java Province, Indonesia. Bali Medical Journal [Internet]. 2021 Apr 28 [cited 2023 Jun 30];10(1):167–73. Available from: https://www.balimedicaljournal.org/index.php/bmj/article/view/2281
23. Mizgier M, Jarząbek-Bielecka G, Wendland N, Jodłowska-Siewert E, Nowicki M, Brożek A, et al. Relation between inflammation, oxidative stress, and macronutrient intakes in normal and excessive body weight adolescent girls with clinical features of polycystic ovary syndrome. Nutrients. 2021 Mar 1;13(3):1–16.
24. Risdiyaningsih V, Kurniawati EY, Darmawati D, Kesehatan P, Khasanah U. FAKTOR RISIKO TERJADINYA SINDROM OVARIUM POLIKISTIK (SOPK). Jurnal Ilmu Kebidanan [Internet]. 2023 Jun 30 [cited 2024 Feb 16];9(2):107–11. Available from: http://jurnalilmukebidanan.akbiduk.ac.id/index.php/jik/article/view/209
25. Naz MSG, Tehrani FR, Lak TB, Mohammadzadeh F, Nasiri M, Badr FK, et al. Quality of life and emotional states of depression, anxiety and stress in adolescents with polycystic ovary syndrome: A cross-sectional study. Psychol Res Behav Manag [Internet]. 2020 [cited 2024 Jan 23];13:203–9. Available from: https://www.tandfonline.com/action/journalInformation?journalCode=dprb20
26. Jaralba JR, Baldovino R, Co H. A Machine Learning Approach for Initial Screening of Polycystic Ovarian Syndrome (PCOS). Lecture Notes in Networks and Systems [Internet]. 2021 [cited 2024 Feb 16];183:517–29. Available from: https://link.springer.com/chapter/10.1007/978-3-030-66840-2_39
27. Xu H, Feng G, Shi L, Han Y, Huang Q, Li R. PCOSt: A non-invasive and cost-effective screening tool for polycystic ovary syndrome. 2023 [cited 2024 Feb 16]; Available from: https://doi.org/10.1016/j.xinn.2023.100407
28. Lin H, Liu M, Zhong D, Ng EHY, Liu J, Li J, et al. The Prevalence and Factors Associated With Anxiety-Like and Depression-Like Behaviors in Women With Polycystic Ovary Syndrome. Front Psychiatry. 2021 Oct 20;12:709674.
29.Mirzohidovna HE. OBESITY AS A RISK FACTOR FOR RECURRENT POLYCYSTIC OVARY DISEASE. Asian journal of pharmaceutical and biological research [Internet]. 2021 Oct 15 [cited 2024 Jan 15];10(3). Available from: https://www.ajpbr.org/index.php/ajpbr/article/view/41
30. Chappell NR, Gibbons WE, Blesson CS. Pathology of hyperandrogenemia in the oocyte of polycystic ovary syndrome. Steroids. 2022 Apr 1;180:108989.
31. Chauvin S, Cohen-Tannoudji J, Guigon CJ. Estradiol Signaling at the Heart of Folliculogenesis: Its Potential Deregulation in Human Ovarian Pathologies. International Journal of Molecular Sciences 2022, Vol 23, Page 512 [Internet]. 2022 Jan 3 [cited 2023 Jun 24];23(1):512. Available from: https://www.mdpi.com/1422-0067/23/1/512/htm
32. Arpita Roy; Gohwar Rashid; Nihad Ashraf Khan. Polycystic Ovary Syndrome (PCOS) and Our Biological Clock. In: Arpita Roy; Gohwar Rashid; Nihad Ashraf Khan, editor. Polycystic Ovarian Syndrome and Our Biological Clock [Internet]. 1st ed. New York: Arpita Roy; Gohwar Rashid; Nihad Ashraf Khan; 2023 [cited 2024 Feb 16]. p. 1–323. Available from: https://www.researchgate.net/profile/Haleema-Ahmad-3/publication/377078011_Several_Diagnostic_Tools_and_Tests_For_The_Analysis_of_PCOS_and_Their_Current_Advancements/links/659465b06f6e450f19c48ac7/Several-Diagnostic-Tools-and-Tests-For-The-Analysis-of-PCOS-and-Their-Current-Advancements.pdf#page=109
33. Kr N, Nataraj R. Hormones of HPG-axis and their Active Role during Chronic Stress and PCOS Induction: A Review. International Journal of Basic and Applied Sciences [Internet]. 2022 [cited 2024 Feb 16];11(1):1–8. Available from: https://doi-ds.org/doilink/10.2020-51948721/
34. Burnatowska E, Wikarek A, Oboza P, Ogarek N, Glinianowicz M, Kocelak P, et al. Emotional Eating and Binge Eating Disorders and Night Eating Syndrome in Polycystic Ovary Syndrome—A Vicious Circle of Disease: A Systematic Review. Nutrients. 2023 Jan 1;15(2).
35. Anand S, Jahan N, Manglani A. Eating Behaviour, Sleep Quality, and Emotional Disturbance in women with Poly Cystic Ovary Syndrome (PCOS) Eating Behaviour, Sleep Quality, and Emotional Disturbance in women with Poly Cystic Ovary Syndrome (PCOS). NeuroQuantology [Internet]. 2022 [cited 2024 Jan 22];20(2):634–9. Available from: www.neuroquantology.com.https://orcid.org/0000-0001-7903-9415.https://orcid.org/0000-0001-9672-4801
36. Naillat F. From Ovarian Development to Folliculogenesis: Essential Networks Sustaining the Ovarian Reserve. OBM Genetics 2022, Vol 6, 153 [Internet]. 2022 Apr 26 [cited 2023 Jun 24];6(2):1–17. Available from: https://www.lidsen.com/journals/genetics/genetics-06-02-153
DOI: https://doi.org/10.22146/jkr.72468
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