Pengaruh puasa intermiten 5:2 terhadap kadar malondialdehida pada karyawan pria dewasa dengan obesitas

https://doi.org/10.22146/ijcn.61765

Karima Yudhistina(1), Erfi Prafiantini(2), Novi Silvia Hardiany(3*)

(1) Departemen Ilmu Gizi, Fakultas Kedokteran Universitas Indonesia, Jakarta
(2) Departemen Ilmu Gizi, Fakultas Kedokteran Universitas Indonesia, Jakarta
(3) Departemen Biokimia dan Biologi Molekuler, Fakultas Kedokteran Universitas Indonesia, Jakarta
(*) Corresponding Author

Abstract


Effect of intermittent fasting 5:2 on plasma malondialdehyde levels in adult male employees with obesity

Background: Obesity is a major risk factor for various non-communicable diseases such as type 2 diabetes mellitus and cardiovascular disease. In obesity, the free radical product will be produced, such as malondialdehyde (MDA) which plays a role in the pathogenesis of various diseases. Intermittent fasting (IF) is an alternative way to reduce free radical levels in the body therefore it can prevent complications of obesity. However, the effect of IF on MDA level in an obese adult male in Jakarta has not been reported.

Objective: The objective of this study was to determine the effect of IF on malondialdehyde levels in adult male employees with obesity in Jakarta.

Methods: This study used a randomized controlled clinical trial. The subjects were men aged 19-59 years with a body mass index (BMI) ≥ 25 kg/m2, divided into fasting and control groups, each group consists of 25 subjects. Intermittent fasting 5:2 is calorie restriction up to 20-25% was done every Monday and Thursday, and not allowed to eat and drink during 14 hours of fasting. Before the intervention, both groups were given education about balanced nutrition. Association of intermittent fasting with MDA and catalase was analyzed by means of difference formula with a significance limit of 5%.

Results: MDA levels post-intervention significantly decreased compared to the pre-intervention both in the fasting group [1,3(0,9-2) nmol/mL to 0,4(0,3-0,6) nmol/mL] and in the control groups [1,4(0,9-1,9) nmol/mL to 0,5(0,3-0,7) nmol/mL]. MDA level post-intervention in the fasting group was significantly lower (p<0,05) compared to the control group.

Conclusions: Intermittent fasting 5:2 during 8 weeks can decrease MDA levels in adult males with obesity in Jakarta.


Keywords


intermittent fasting; malondialdehyde; obesity; oxidative stress

Full Text:

PDF


References

  1. Marseglia L, Manti S, D’Angelo G, Nicotera A, Parisi E, Di Rosa G, et al. Oxidative stress in obesity: a critical component in human diseases. Int J Mol Sci. 2015;16(1):378-400. doi: 10.3390/ijms16010378
  2. World Health Organization. Fact sheet: what causes overweight and obesity?. South-East Asia: WHO; 2011.
  3. World Health Organization. Regional Office for South-East Asia. Noncommunicable diseases in the South-East Asia Region, 2011: situation and response. [series online] 2012 [cited 2020 April 21]. Available online: URL: https://apps.who.int/iris/handle/10665/205578
  4. Kementerian Kesehatan RI. Hasil utama Riskesdas penyakit tidak menular 2018. Jakarta: Kemenkes RI; 2018.
  5. Nurwanti E, Uddin M, Chang JS, Hadi H, Syed-Abdul S, Su ECY, et al. Roles of sedentary behaviors and unhealthy foods in increasing the obesity risk in adult men and women: a cross-sectional national study. Nutrients. 2018;10(6):704. doi: 10.3390/nu10060704
  6. Monica. Perbedaan shift kerja, asupan zat gizi makro, work family conflict self efficacy dan faktor lainnya pada kejadian obesitas kalangan pekerja PT X tahun 2017 [Skripsi]. Jakarta: FKM Universitas Indonesia; 2017.
  7. Lestari DI. Pengaruh kebiasaan merokok terhadap obesitas dan overweight pada karyawan universitas di Jakarta. Jurnal Muara. 2017;1(1):204-9.doi: 10.24912/jmstkik.v1i1.431
  8. Anton S, Leeuwenburgh C. Fasting or caloric restriction for healthy aging. Exp Gerontol. 2013;48(10):1003-5. doi: 10.1016/j.exger.2013.04.011
  9. Sutton EF, Beyl R, Early KS, Cefalu WT, Ravussin E, Peterson CM, et al. Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes. Cell Metab. 2018;27(6):1212-21.e3. doi: 10.1016/j.cmet.2018.04.010
  10. Stockman M, Thomas D, Burke J, Apovian CM. Intermittent fasting : is the wait worth the weight ?. Curr Obes Rep. 2018;7(2):172-85. doi: 10.1007/s13679-018-0308-9
  11. Teng NIMF, Shahar S, Rajab NF, Manaf ZA, Johari MH, Ngah WZW. Improvement of metabolic parameters in healthy older adult men following a fasting calorie restriction intervention. Aging Male. 2013;16(4):177-83. doi: 10.3109/13685538.2013.832191
  12. World Health Organization. Regional Office for the Western Pacific. The Asia-Pacific perspective: redefining obesity and its treatment. [series online] 2000 [cited 2020 April 21]. Available online: URL: https://apps.who.int/iris/handle/10665/206936
  13. Patterson RE, Laughlin GA, Sears DD, LaCroix AZ, Marinac C, Gallo LC, et al. Intermittent fasting and human metabolic health. J Acad Nutr Diet. 2015;115(8):1203-12. doi: 10.1016/j.jand.2015.02.018
  14. Craig CL, Marshall AL, Sjöström M, Bauman AE, Booth ML, Ainsworth BE, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003;35(8):1381-95. doi: 10.1249/01.MSS.0000078924.61453.FB
  15. Tsikas D. Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges. Anal Biochem. 2017;524:13-30. doi: 10.1016/j.ab.2016.10.021
  16. Hardiany NS, Sucitra, Paramita R. Profile of malondialdehyde (MDA) and catalase specific activity in plasma of elderly woman. Heal Sci J Indones. 2019;10(2):132-6. doi: 10.22435/hsji.v12i2.2239
  17. Longo VD, Mattson PM. Fasting: molecular mechanism and clinical application. Cell Metab. 2014;19(2):181-92. doi: 10.1016/j.cmet.2013.12.008
  18. Lee C, Longo VD. Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients. Oncogene. 2011;30(30):3305-16. doi: 10.1038/onc.2011.91
  19. Hartman AL, Rubenstein JE, Kossoff EH. Intermittent fasting: a “new” historical strategy for controlling seizures?. Epilepsy Res. 2013;104(3):275-9. doi: 10.1016/j.eplepsyres.2012.10.011
  20. Anton SD, Moehl K, Donahoo WT, Marosi K, Lee SA, Mattson MP, et al. Flipping the metabolic switch: understanding and applying the health benefits of fasting. Obesity (Silver Spring). 2018;26(2):254-68. doi: 10.1002/oby.22065
  21. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Shimomura I, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2004;114(12):1752-61. doi: 10.1172/JCI21625
  22. Matsuda M, Shimomura I. Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. Obes Res Clin Pract. 2013;7(5): e330-41. doi: 10.1016/j.orcp.2013.05.004



DOI: https://doi.org/10.22146/ijcn.61765

Article Metrics

Abstract views : 7556 | views : 6924

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2021 Jurnal Gizi Klinik Indonesia

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Jurnal Gizi Klinik Indonesia (JGKI) Indexed by:
 
  

  free web stats View My Stats