Pengaruh puasa intermiten 5:2 terhadap kadar malondialdehida pada karyawan pria dewasa dengan obesitas
Karima Yudhistina(1), Erfi Prafiantini(2), Novi Silvia Hardiany(3*)
(1) Departemen Ilmu Gizi, Fakultas Kedokteran Universitas Indonesia, Jakarta
(2) Departemen Ilmu Gizi, Fakultas Kedokteran Universitas Indonesia, Jakarta
(3) Departemen Biokimia dan Biologi Molekuler, Fakultas Kedokteran Universitas Indonesia, Jakarta
(*) Corresponding Author
Abstract
Effect of intermittent fasting 5:2 on plasma malondialdehyde levels in adult male employees with obesity
Background: Obesity is a major risk factor for various non-communicable diseases such as type 2 diabetes mellitus and cardiovascular disease. In obesity, the free radical product will be produced, such as malondialdehyde (MDA) which plays a role in the pathogenesis of various diseases. Intermittent fasting (IF) is an alternative way to reduce free radical levels in the body therefore it can prevent complications of obesity. However, the effect of IF on MDA level in an obese adult male in Jakarta has not been reported.
Objective: The objective of this study was to determine the effect of IF on malondialdehyde levels in adult male employees with obesity in Jakarta.
Methods: This study used a randomized controlled clinical trial. The subjects were men aged 19-59 years with a body mass index (BMI) ≥ 25 kg/m2, divided into fasting and control groups, each group consists of 25 subjects. Intermittent fasting 5:2 is calorie restriction up to 20-25% was done every Monday and Thursday, and not allowed to eat and drink during 14 hours of fasting. Before the intervention, both groups were given education about balanced nutrition. Association of intermittent fasting with MDA and catalase was analyzed by means of difference formula with a significance limit of 5%.
Results: MDA levels post-intervention significantly decreased compared to the pre-intervention both in the fasting group [1,3(0,9-2) nmol/mL to 0,4(0,3-0,6) nmol/mL] and in the control groups [1,4(0,9-1,9) nmol/mL to 0,5(0,3-0,7) nmol/mL]. MDA level post-intervention in the fasting group was significantly lower (p<0,05) compared to the control group.
Conclusions: Intermittent fasting 5:2 during 8 weeks can decrease MDA levels in adult males with obesity in Jakarta.
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- Marseglia L, Manti S, D’Angelo G, Nicotera A, Parisi E, Di Rosa G, et al. Oxidative stress in obesity: a critical component in human diseases. Int J Mol Sci. 2015;16(1):378-400. doi: 10.3390/ijms16010378
- World Health Organization. Fact sheet: what causes overweight and obesity?. South-East Asia: WHO; 2011.
- World Health Organization. Regional Office for South-East Asia. Noncommunicable diseases in the South-East Asia Region, 2011: situation and response. [series online] 2012 [cited 2020 April 21]. Available online: URL: https://apps.who.int/iris/handle/10665/205578
- Kementerian Kesehatan RI. Hasil utama Riskesdas penyakit tidak menular 2018. Jakarta: Kemenkes RI; 2018.
- Nurwanti E, Uddin M, Chang JS, Hadi H, Syed-Abdul S, Su ECY, et al. Roles of sedentary behaviors and unhealthy foods in increasing the obesity risk in adult men and women: a cross-sectional national study. Nutrients. 2018;10(6):704. doi: 10.3390/nu10060704
- Monica. Perbedaan shift kerja, asupan zat gizi makro, work family conflict self efficacy dan faktor lainnya pada kejadian obesitas kalangan pekerja PT X tahun 2017 [Skripsi]. Jakarta: FKM Universitas Indonesia; 2017.
- Lestari DI. Pengaruh kebiasaan merokok terhadap obesitas dan overweight pada karyawan universitas di Jakarta. Jurnal Muara. 2017;1(1):204-9.doi: 10.24912/jmstkik.v1i1.431
- Anton S, Leeuwenburgh C. Fasting or caloric restriction for healthy aging. Exp Gerontol. 2013;48(10):1003-5. doi: 10.1016/j.exger.2013.04.011
- Sutton EF, Beyl R, Early KS, Cefalu WT, Ravussin E, Peterson CM, et al. Early time-restricted feeding improves insulin sensitivity, blood pressure, and oxidative stress even without weight loss in men with prediabetes. Cell Metab. 2018;27(6):1212-21.e3. doi: 10.1016/j.cmet.2018.04.010
- Stockman M, Thomas D, Burke J, Apovian CM. Intermittent fasting : is the wait worth the weight ?. Curr Obes Rep. 2018;7(2):172-85. doi: 10.1007/s13679-018-0308-9
- Teng NIMF, Shahar S, Rajab NF, Manaf ZA, Johari MH, Ngah WZW. Improvement of metabolic parameters in healthy older adult men following a fasting calorie restriction intervention. Aging Male. 2013;16(4):177-83. doi: 10.3109/13685538.2013.832191
- World Health Organization. Regional Office for the Western Pacific. The Asia-Pacific perspective: redefining obesity and its treatment. [series online] 2000 [cited 2020 April 21]. Available online: URL: https://apps.who.int/iris/handle/10665/206936
- Patterson RE, Laughlin GA, Sears DD, LaCroix AZ, Marinac C, Gallo LC, et al. Intermittent fasting and human metabolic health. J Acad Nutr Diet. 2015;115(8):1203-12. doi: 10.1016/j.jand.2015.02.018
- Craig CL, Marshall AL, Sjöström M, Bauman AE, Booth ML, Ainsworth BE, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003;35(8):1381-95. doi: 10.1249/01.MSS.0000078924.61453.FB
- Tsikas D. Assessment of lipid peroxidation by measuring malondialdehyde (MDA) and relatives in biological samples: analytical and biological challenges. Anal Biochem. 2017;524:13-30. doi: 10.1016/j.ab.2016.10.021
- Hardiany NS, Sucitra, Paramita R. Profile of malondialdehyde (MDA) and catalase specific activity in plasma of elderly woman. Heal Sci J Indones. 2019;10(2):132-6. doi: 10.22435/hsji.v12i2.2239
- Longo VD, Mattson PM. Fasting: molecular mechanism and clinical application. Cell Metab. 2014;19(2):181-92. doi: 10.1016/j.cmet.2013.12.008
- Lee C, Longo VD. Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients. Oncogene. 2011;30(30):3305-16. doi: 10.1038/onc.2011.91
- Hartman AL, Rubenstein JE, Kossoff EH. Intermittent fasting: a “new” historical strategy for controlling seizures?. Epilepsy Res. 2013;104(3):275-9. doi: 10.1016/j.eplepsyres.2012.10.011
- Anton SD, Moehl K, Donahoo WT, Marosi K, Lee SA, Mattson MP, et al. Flipping the metabolic switch: understanding and applying the health benefits of fasting. Obesity (Silver Spring). 2018;26(2):254-68. doi: 10.1002/oby.22065
- Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Shimomura I, et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest. 2004;114(12):1752-61. doi: 10.1172/JCI21625
- Matsuda M, Shimomura I. Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer. Obes Res Clin Pract. 2013;7(5): e330-41. doi: 10.1016/j.orcp.2013.05.004
DOI: https://doi.org/10.22146/ijcn.61765
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