Pengaruh pemberian jus jamur tiram terhadap kadar kolesterol, trigliserida, dan malondialdehid penderita hiperkolesterolemia

https://doi.org/10.22146/ijcn.40813

Fera Nofiartika(1*), Yunita Indah Prasetyaningrum(2)

(1) Program Studi Gizi, Universitas Respati Yogyakarta
(2) Program Studi Gizi, Universitas Respati Yogyakarta
(*) Corresponding Author

Abstract


The effect of white oyster mushroom juice (Pleurotus ostreatus) to total cholesterol, triglyceride, and malondialdehyde (MDA) levels in patients with hypercholesterolemia

Background: The high incidence of hypercholesterolemia due to the wrong diet is a health problem that needs to be addressed immediately. One food ingredient that is being cultivated and believed to have a hypocholesterolemic effect is a white oyster mushroom (Pleurotus ostreatus). These foods contain water-soluble fiber (β glucans) and lovastatin which are useful for improving lipid profiles.

Objective: To determine the effect of white oyster mushroom juice (Pleurotus ostreatus) to total cholesterol, triglyceride, and malondialdehyde (MDA) levels in patients with hypercholesterolemia.

Methods: This is a quasi-experimental study with a pretest and posttest design. This study was conducted by giving white oyster mushroom juice (Pleurotus ostreatus) for 14 days and then measured its effect on total cholesterol, triglyceride, and MDA levels. The location of the study in Pisangan Tridadi Sleman and the respondent was adults aged 18-55 years who had hypercholesterolemia. Data collection of lipid profiles was taken from venous plasma blood after 12 hours of fasting. While MDA levels were measured by using the thiobarbituric acid (TBA) method. The changes in cholesterol, triglycerides, and MDA levels after administration of white oyster mushroom juice analyzed using paired-t-test and Wilcoxon signed-rank test.

Results: The oyster mushroom juice affected decreasing triglyceride levels (2.27 mg/dL; p=0.023). There was no difference in the mean total cholesterol and MDA levels between before and after the intervention.

Conclusions: Consumption of white oyster mushroom juice for 14 days significantly reduce triglyceride levels in patients with hypercholesterolemia.


Keywords


hypercholesterolemia; malondialdehyde; total cholesterol; triglyceride; white oyster mushroom

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References

  1. Kalim. Peranan statin pada sindroma koroner akut. Jakarta: Bagian Kardiologi FK UI – RSJN Harapan Kita; 2005.
  2. Jezovnik MK, Poredos P. Oxidative stress and atherosclerosis. E-Journal of Cardiology Practice. 2007;6(6):1-3.
  3. Kemenkes RI. Riset kesehatan dasar. Jakarta: Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan Republik Indonesia; 2013.
  4. Schneider I, Kressel G, Meyer A, Krings U, Berger RG, Hahn A. Lipid lowering effect of oyster mushroom (Pleurotus ostreatus) in humans. J Funct Foods. 2011; 3(1):17-24. doi: 10.1016/j.jff.2010.11.004
  5. Otunola GA, Oyelola BO, Adenike TO, Anton AA. Effect of diet-induced hypercholesterolemia on the lipid profil and some enzyme activities in female wistar rats. Afr J Biochem Res. 2010;4(6):149-54.
  6. Stapleton PA, Goodwill AG, James ME, Brock RW, Frisbee JC. Hypercholesterolemia and microvascular dysfungction: interventional strategies. J Inflamm. 2010;7:54. doi: 10.1186/1476-9255-7-54
  7. Setyaningsih M, Sri A. Kandungan kolesterol serum dan sifat digesta tikus Sprague dawley hiperkolesterolemia yang diberi pakan jamur tiram putih (Pleurotus ostreatus) olahan [Tesis]. Yogyakarta: Universitas Gadjah Mada; 2013.
  8. Purbaningrum L, Orbaniyah S. Pengaruh kapsul pleurotus ostreatus terhadap kadar kolesterol pada lanjut usia hiperkolesterolemia. Mutiara Medika. 2012;12(2):109-15.
  9. Salvado JS, Bullo M, Heraz AP, Ross E. Dietary fiber, nuts, and cardiovascular disease. BNJ. 2006;96(Suppl 2):S45-S51. doi: 10.1017/BJN20061863
  10. Santoso F, Priyo W, Elly W. Uji aktivitas antihiperkolesterol ekstrak beta glukan larut alkali jamur tiram putih pada hamster hiperkolesterolemia [Skripsi]. Jakarta: Universitas Muhammadiyah Prof Dr Hamka; 2013.
  11. Alarcón J, Aguila S, Arancibia-Avila P, Fuentes O, Zamorano-Ponce E, Hernández M. Production and purification of statins from Pleurotus ostreatus (Basidiomycetes) strains. 2003; Z Naturforsch C J Biosci. 2003;58(1-2):62-4. doi: 10.1515/znc-2003-1-211
  12. Newman DH. The statins in preventive cardiology. N Engl J Med. 2009;360(5):541. doi: 10.1056/NEJMc082218
  13. Singh UN, Kumar S, Dhakal S. Study of oxidative stress in hypercholesterolemia. International Journal of Contemporary Medical Research. 2017;4(5):1204-7.
  14. Lemeshow S, David WHJr. Besar sampel dalam penelitian kesehatan (terjemahan). Yogyakarta: Gadjahmada University Press; 1997.
  15. Hanson DS, Duane WC. Effects of lovastatin and chenodiol on bile acid synthesis, bile lipid composition, and biliary lipid secretion in healthy human subjects. J Lipid Res. 1994;35(8):1462-8.
  16. Chu J, Igbetar BD, Orfila C. Fibrous cellular structures are found in a commercial fruit smoothie and remain intact during simulated digestion. J Nutr Food Sci. 2017;7:576. doi: 10.4172/2155-9600.1000576
  17. Rogers PJ, Shahrokni R. A comparison of the satiety effects of a fruit smoothie, its fresh fruit equivalent and other drinks. Nutrients. 2018;10(4):E431. doi: 10.3390/nu10040431
  18. Miller M, Stone N, Ballantyne C, Bittner V, Criqui M, Ginsberg H, et al. Tryglicerides and cardiovascular disease: a scientific statement from the American Hearth Assosiation. Circulation. 2011;123(20):2292-333. doi: 10.1161/CIR.0b013e3182160726
  19. Byun J, Han Y, Lee S. The effects of yellow soybean, black soybean, and sword bean on lipid levels and oxidative stress in ovariectomized rats. Int J Vitam Nutr Res. 2010;80(2):97-106. doi: 10.1024/0300-9831/a000010
  20. Haring R, Baumeister S, Volzke H, Dorr M, Felix S, Wallaschofski H, et al. Prospective association of low total testosterone concentration with an adverselipid profile and increased incident dyslipidemia. Eur J Cardiovasc Prev Rehabil. 2011;18(1):86-96. doi: 10.1097/HJR.0b013e32833c1a8d
  21. Afiah, Rahayuningsih HM. Pengaruh pemberian sup jamur tiram putih (Pleurotus ostreatus) terhadap kadar kolesterol total subjek obesitas. Journal of Nutrition College. 2014;3(4):465-72. doi: 10.14710/jnc.v3i4.6828
  22. Bobek P, Ozdin L, Galbavy S. Dose and time-dependent hypocholesterolemic effect of oyster mushroom (Pleurotus ostreatus) in rats. Nutrition. 1998;14(3):282-6. doi: 10.1016/s0899-9007(97)00471-1
  23. Ericsson S, Eriksson M, Vitols S, Einarsson K, Berglund L, Angelin B. Influence of age on the metabolism of plasma low density lipoproteins in healthy males. J Clin Invest. 1991;87(2):591-6. doi: 10.1172/JCI115034
  24. Hardianto D. Tinjauan lovastatin dan aplikasinya. Jurnal Bioteknologi & Biosains Indonesia. 2014;1(1):38-44. doi: 10.29122/jbbi.v1i1.550
  25. Mowsumi FR, Choudhury MBK. Oyster mushroom: biochemical and medicinal prospects. Bangladesh J Med Biochem. 2010; 3(1):23-8. doi: 10.3329/bjmb.v3i1.13804
  26. Aida F, Shuhaimia M, Yazid M, Maaruf A. Mushroomas a potential source of prebiotics: a review. Trends Food Sci Tech. 2009;20(11-12):567-75. doi: 10.3329/bjmb.v3i1.13804
  27. Mursito B, Jenie UA, Mubarika S, Kardono LBS. Lowering cholesterol effect of beta glukans of isolated termitomyces eurrhizus extracts by oral administration to rats. Journal of Pharmacology and Toxicology. 2011;6:90-6. doi: 10.3923/jpt.2011.90.961



DOI: https://doi.org/10.22146/ijcn.40813

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