Indeks massa tubuh, asupan vitamin D, dan serum 25-hydroxyvitamin D pada pasien kanker payudara

https://doi.org/10.22146/ijcn.17243

Amilia Yuni Damayanti(1*), Dono Indarto(2), Brian Wasita(3), Tonang Dwi Ardyanto(4)

(1) Program Studi Gizi, Fakultas Ilmu Kesehatan Universitas Darussalam Gontor
(2) Pascasarjana Universitas Sebelas Maret Surakarta
(3) Pascasarjana Universitas Sebelas Maret Surakarta
(4) Pascasarjana Universitas Sebelas Maret Surakarta
(*) Corresponding Author

Abstract


Background: Breast cancer is the most common malignancy in women in the world. Vitamin D helps control the majority of gene expression in female reproductive tissues. Body mass index (BMI) influences the bioavailability of vitamin D. Diet is one of the main sources of vitamin D and it is directly converted into 25-hydroxyvitamin D [25 (OH) D] in the liver.

Objective: This study aimed to analyze the relationship between BMI and vitamin D intake and 25 (OH)D serum in patients with breast cancer.

Method: Analytic observational with cross sectional design was used in this study. A total of 37 breast cancer patient visited Dr. Moewardi Hospital in Surakarta was selected as research subjects using a purposive sampling technique. BMI data was obtained by measuring body weight and height. Vitamin D intake was determined using 1 x 24-hour food recall and semi-quantitative food frequency questionnaire. While, 25(OH)D serum was measured using enzyme-linked immunoabsorbent assay. Data analysis used Spearman correlation test.

Results: The averages of BMI, vitamin D intake and 25(OH)D serum of breast cancer patients were 21.96±3.63 kg/m², 3.50±3.30 µg/day and 16.01±14.67 ng/mL respectively. Most breast cancer patients had less vitamin D intake and 25(OH)D serum deficiency. There was a weak relationship between BMI (r=0.188, p=0.266) and vitamin D (r=0.113, p=0.507) and 25 (OH)D serum in breast cancer patients.

Conclusion: There were no significant correlations between BMI and vitamin D intake with 25(OH)D serum in breast cancer patients. Further study is required on the effect of chemotherapy regimens on vitamin D metabolism.


Keywords


BMI; breast cancer; vitamin D intake; 25(OH)D serum

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References

  1. World Health Organization (WHO). Latest world cancer statistics global cancer burden rises to 14.1 million new cases in 2012: Marked increase in breast cancers must be addressed. [series online] IARC 2012 [cited 2016 Jan 25]. Available from: URL: https://www.iarc.fr/en/media-centre/pr/2013/pdfs/pr223_E.pdf
  2. Kementerian Kesehatan Republik Indonesia (Kemenkes RI). Pusat data dan informasi (infodatin). [series online] 2015 [cited 2016 Jan 25]. Available from: URL: http://www.depkes.go.id>infodatin-kanker
  3. Rekam Medik RSUD Dr. Moewardi Surakarta. Data pasien kanker payudara rawat jalan tahun 2014-2015. Surakarta: RSUD Dr. Moewardi; 2015.
  4. Kementerian Kesehatan Republik Indonesia (Kemenkes RI). Panduan nasional penanganan kanker nasional “kanker payudara”. Komite Penanggulangan Kanker Nasional. [series online] 2015 [cited 2016 Jan 25]. Available from: URL: http://www.depkes.go.id>kanker-payudara.
  5. Peto R, Davies C, Godwin J, Gray R, Pan HC, et al. Comparisons between different polychemotherapy regimens for early breast cancer: meta-analyses of long-term outcome among 100,000 women in 123 randomised trials. Lancet 2012;379(9814):432-44.
  6. Shao T, Klein P, Grossbard ML. Vitamin D and breast cancer. Oncologist 2012;17(1):36-45.
  7. Krishnan AV, Swami S, Feldman D. The potential therapeutic benefits of vitamin D in the treatment of estrogen receptor positive breast cancer. Steroids 2012;77(11):1107-12.
  8. Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr 2005;135(2):317-22.
  9. Jorde R, Sneve M, Emaus N, Figenschau Y, Grimnes G. Cross-sectional and longitudinal relation between serum 25-hydroxyvitamin D and body mass index: the Tromso study. Eur J of Nutr 2010;49(7):401-7.
  10. Drincic AT, Armas LA, Van Diest EE, Heaney RP. Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity. Obesity 2012;20(7):1444-8.
  11. Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000;72(3):690-3.
  12. Vashi P, Lammersfeld CA, Braun DP, Gupta D. Serum 25-hydroxyvitamin D is inversely associated with body mass index in cancer. J Nutr 2011;1(10):51.
  13. Jacobs ET, Thomson CA, Flatt SW, Newman VA, Rock CL, Pierce JP. Correlates of 25-hydroxyvitamin D and breast cancer stage in the women’s healthy eating and living study. Nutr Cancer 2013;65(2):188-94.
  14. Shirazi L, Almquist M, Malm J, Wirfält E, Manjer J. Determinants of serum levels of vitamin D: a study of life-style, menopausal status, dietary intake, serum calcium, and PTH. BMC Women's Health 2013;1(13):33.
  15. Departemen Kesehatan Republik Indonesia (Depkes RI). Peraturan Menteri Kesehatan Republik Indonesia nomor 75 tahun 2013 tentang angka kecukupan gizi yang dianjurkan bagi Bangsa Indonesia. [series online] 2013 [cited 2016 Jan 25]. Available from: URL: http://gizi.depkes.go.id/download/Kebijakan%20Gizi/PMK%2075-2013.pdf.
  16. Moan J, Lagunova Z, Lindberg FA, Porojnicu AC. Seasonal variation of 1,25-dihydroxyvitamin D and its association with body mass index and age. J Steroid Biochem Mol Biol 2009;113(3-5):217-21.
  17. Vuolo L, Somma CD, Faggiano A, Colao A. Vitamin D and cancer. Front Endocrinol 2012;3(1):58.
  18. Morton ML, Thompson CL. Decreasing 25-hydroxy-vitamin D levels account for portion of the effect of increasing body mass index on breast cancer mortality. Mol Nutr Food Res 2013;57(2):260-6.
  19. Vilarrasa N, Maravall J, Estepa A, Sanchez R, Masdevall C, Navarro MA, et al. Low 25-hydroxyvitamin D concentrations in obese women: their clinical significance and relationship with anthropometric and body composition variables. J Endocrinol Invest 2007;30(8):653-8.
  20. Yildizhan R, Kurdoglu M, Adali E, Kolusari A, Yildizhan B, Sahin HG, et al. Serum 25-hydroxyvitamin D concentrations in obese and non-obese women with polycystic ovary syndrome. Arch Gynecol Obstet 2009;280(4):559-63.
  21. Yousef FM, Jacobs ET, Kang PT, Hakim IA, Going S, Yousef JM, et al. Vitamin D status and breast cancer in saudi arabian women: case control study. Am J Clin Nutr 2013;98(1):105-10.
  22. Alco G, Igdem S, Dincer M, Ozmen V, Saglam S, Selamoglu D, et al. Vitamin D levels in patients with breast cancer: importance of dressing style. Asian Pac J Cancer Prev 2014;15(3):1357-62.
  23. Vashi PG, Lammersfeld CA, Braun DP, Gupta D. Serum 25-hydroxyvitamin D is inversely associated with body mass index in cancer. Nutr J 2011;10(1):51.
  24. La Vecchia C, Giordano SH, Hortobagyi GN, Chabner B. Overweight, obesity, diabetes, and risk of breast cancer: interlocking pieces of the puzzle. Oncologist 2011;16(6):726-9.
  25. Kaaks R, Berrino F, Key T, Rinaldi S, Dossus L, Biessy C, et al. Serum sex steroids in premenopausal women and breast cancer risk within the European prospective investigation into cancer and nutrition (EPIC). J Natl Cancer Inst 2005;97(10):755-65.
  26. Jarde T, Perrier S, Vasson MP, Caldefie-Cheze F. Molecular mechanisms of leptin and adiponectin in breast cancer. Eur J Cancer 2011;47(1):33-43.
  27. Kruger MC, Schollum LM, Kuhn-Sherlock B, Hestiantoro A, Wijanto P, Li-Yu J, et al. The effect of a fortified milk drink on vitamin D status and bone turnover in post-menopausal women from South East Asia. Bone 2010;46(3):759-67.
  28. Dinizulu T, Griffin D, Carey J, Mulkerrin E. Vitamin D supplementation versus combined calcium and vitamin D in older female patients - an observational study. J Nutr Health Aging 2011;15(8):605-8.
  29. Lopes N, Paredes J, Costa JL, Ylstra B, Schmitt F. Vitamin D and the mammary gland: a review on its role in normal development and breast cancer. Breast Cancer Res 2012;14(3):211.
  30. Mohr SB, Gorham ED, Alcaraz JE, Kane CI, Macera CA, Parsons JK, et al. Does the evidence for an inverse relationship between serum vitamin D status and breast cancer risk satisfy the Hill criteria?. Dermatoendocrinol 2012;4(2):152-7.
  31. Rulianti MR, Almasdy D, Murni AW. Hubungan depresi dan sindrom dispepsia pada pasien penderita keganasan yang menjalani kemoterapi di RSUP Dr. M. Djamil Padang. Jurnal Kesehatan Andalas 2013;2(3);137-40.
  32. Bidgoli SA, Azarshab H. Role of vitamin D deficiency and lack of sun exposure in the incidence of premenopausal breast cancer: a case control study in Sabzevar, Iran. Asian Pac J Cancer Prev 2014;15(8):3391-6.
  33. Tsiaras WG, Weinstock MA. Factors influencing vitamin D status. Acta Derm Venereol 2011;91(2):115-24.
  34. Bhutto A, Morley JE. The clinical significance of gastrointestinal changes with aging. Curr Opin Clin Nutr Metab Care 2008;11(5):651-60.
  35. Deeb KK, Trump DL, Johnson CS. Vitamin D signalling pathways in cancer: potential for anti cancer therapeutics. Nature 2007;7(1):684-700.
  36. Norman AW. Minireview: vitamin D receptor: new assignments for an already busy receptor. Endocrinology 2006;147(12):5542-8.
  37. Garland CF, Garland FC, Gorham ED, Lipkin M, Newmark H, Mohr SB, et al. The role of vitamin D in cancer prevention. Am J Public Health 2006;96(2):252-61.
  38. Ko BJ, Kim YS, Kim SG, Park JH, Lee SH, Jeong SW, et al. Relationship between 25-hydroxyvitamin D levels and liver fibrosis as assessed by transient elastography in patients with chronic liver disease. Gut Liver 2016;10(5):818-25.
  39. Ko EJ, Kim BH, Jeong HY, Soe SU, Yang DH, Lee SY. Serum 25-hydroxyvitamin D as a predictor of hospitalization-free survival in predialysis and dialysis patients with chronic kidney disease: a single-center prospective observational analysis. Kidney Res Clin Pract 2016;35(1):22-8.
  40. Klaus KW, Rowena B, John G, Maria F, Paton HA, Jamil JE, et al. Effects of vitamin D on cardiac function in patients with chronic hf: the Vindicate study. J Am Coll Cardiol 2016;67(22):2593-603.



DOI: https://doi.org/10.22146/ijcn.17243

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