Plasma Angiotensin II Levels In Women With Type 2 Diabetes With Or Without Hypertension

https://doi.org/10.22146/acta%20interna.3872

Etra Ariadno(1*)

(1) 
(*) Corresponding Author

Abstract


ABSTRACT

 

Background. Hypertension is a major risk for the development and progressivity complication of macro and microvascular of diabetes mellitus. Renin-angiotensin-aldosteron system (RAAS), insulin resistance, endothelial dysfunction and autonomic nervous dysfunction play an important part in the pathogenesis of hypertension and type 2 diabetes mellitus. In RAAS, increased angiotensin II constricts arterioles, raises total peripheral resistance and blood volume. The rise in intravascular volume increases risk of hypertension. Glucotoxicity or hyperglycemia in type 2 diabetes mellitus can increases angiotensin II levels.

Aim. To evaluate plasma angiotensin II levels in type 2 diabetes mellitus women with or without hypertension.

Methods. Cross sectional design was conducted on subjects from outpatients’ women with type 2 diabetes mellitus at endocrinology clinic, Dr. Sardjito General Hospital, Yogyakarta. Hypertension was assessed using criteria from Seventh Joint National Committee (2003). ELISA sandwich method was used to measure plasma angiotensin II levels from blood vein. Differences between groups were compared by student’s unpaired t-test and Mann-Whitney test.

Results. Among 60 subjects, there are 30 with hypertension (50%) and 30 without hypertension (50%). Mean age were 54.11 ± 3.36 years old. Plasma angiotensin II levels was higher in women with type 2 diabetes mellitus with hypertension than without hypertension although significance was not reached (0.30 ± 0.15 ng/mL vs. 0.28 ± 0.18 ng/mL, p= 0.93).

Conclusion. The plasma angiotensin II levels are not significantly different between type 2 diabetes mellitus women with or without hypertension.

 

Key words: hypertension, plasma angiotensin II, type 2 diabetes mellitus, women


Full Text:

PDF


References

Atlas, SA. Renin-Angiotensin Aldosteron System: Pathophysiological Role and Pharmacological Inhibition. Supplement to Journal of Managed Care Pharmacy, 2007; 13 (8): 9-20.

Bennet, CM. Guo, M. Dharmage, SC. HbA1c as a screening tool for detection of Type 2 Diabetes: a systematic review. Diabetic Medicine, 2007; 24: 333-43.

Kaplan, NM. Primary Hypertension: Pathogenesis. In: Kaplan’s Clinical Hypertension, 9th edition. Philadelphia. Lippincot Williams & Wilkins, 2006; 50-121.

Matsubara, M. Genetic Determination of Human Essential Hypertension. Tohoku J Exp Med, 2000; 192: 19-33.

Setiati, S. Laksmi, PW. Kesehatan Perempuan. Dalam: Aru WS, Bambang S, Idrus A, Marcellus SK, Siti S (eds). Buku Ajar Ilmu Penyakit Dalam. Edisi ke-4. Fakultas Kedokteran Universitas Indonesia, 2009: 102-09.

Dahlan, MS. Besar Sample dalam Penelitian Kedokteran dan Kesehatan. Dalam: Seri Evidence Based Medicine, 2006: 19-70.

Govindarajan, G, Sowers JR, Stump CS. Hypertension and Diabetes Mellitus. Europ Cardiovasc Diseas, 2006; 3: 1-7.

Bluher, M. Kratzsch, J. Paschke, R. Plasma Levels of Tumor Necrosis Factor-ά, Angiotensin II, Growth Hormone, and IGF-I are not elevated in Insulin-Resistant Individualis With Impaired Glucose Tolerance and Diabetes Mellitus. Diabetes Care, 2001; 24: 328-34.



DOI: https://doi.org/10.22146/acta%20interna.3872

Article Metrics

Abstract views : 868 | views : 692

Refbacks

  • There are currently no refbacks.




Copyright (c) 2013 Acta Interna The Journal of Internal Medicine

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Acta Interna The Journal of Internal Medicine Indexed by:

 

 Indonesia Onesearch Google Scholar IPI Indonesian Publication Index

 website statistics View My Stats  

 

 

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.