Phytochemistry and Biological Activities of  Amomum  Species

Deden Indra Dinata; Rani Maharani; Fauzan Zein Muttaqin; Unang Supratman

doi:10.22146/ijc.95402

Phytochemistry and Biological Activities of Amomum Species

https://doi.org/10.22146/ijc.95402

Deden Indra Dinata⁽¹⁾, Rani Maharani⁽²⁾, Fauzan Zein Muttaqin⁽³⁾, Unang Supratman^(4*)

(1) Faculty of Pharmacy, Bhakti Kencana University, Jl. Soekarno Hatta No. 754, Bandung 40614, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
(2) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia; Central Laboratory of Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
(3) Faculty of Pharmacy, Bhakti Kencana University, Jl. Soekarno Hatta No. 754, Bandung 40614, Indonesia
(4) Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia; Central Laboratory of Universitas Padjadjaran, Jl. Raya Bandung-Sumedang Km. 21, Jatinangor, Sumedang 45363, Indonesia
(*) Corresponding Author

Abstract

Amomum is a pungent and aromatic plant genus that contains 150–180 species, where Southeast Asia is the center of endemism, with Indonesia indigenous to 24 breeds. These species are used as spices and traditional medicine for the treatment of various diseases. This paper aims to provide Amomum species summarized data regarding phytochemistry and biological activities. Several studies have been carried out on the fruits, seeds, roots, rhizomes, and leaves of Amomum species from 1999 to 2024, as approximately 127 metabolites were isolated as flavonoid, diterpenoid, diarylheptanoid, monoterpenoid, sesquiterpenoid, phenylpropanoid, phenolic, and steroid groups. Besides cytotoxicity, anti-oxidant, and anti-inflammatory potentials; it also has an owed tendency for use as a chemical marker. The extracts and compounds obtained from the Amomum species were evaluated for biological activities, including cytotoxicity, anti-oxidant, anti-cancer, anti-proliferative, anti-inflammatory, anti-fungal, anti-microbial, neuroprotective, platelet anti-aggregation, and anti-diabetic properties. Tsaoko arilon (neolignane) had anti-proliferative and cytotoxic activity, with the highest reactions considered as lead compounds for further development. The findings highlighted the significance of using compounds from the Amomum genus in traditional medicine and the discovery of new medicines. Therefore, the results supported the concept of utilizing Amomum species as a potential source for producing biologically active compounds.

Keywords

Amomum; biological activities; phytochemistry; Zingiberaceae

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DOI: https://doi.org/10.22146/ijc.95402