Antimicrobial and Anti-Oxidative Activities of 12-Arylbenzoacridines

Boonsong Wungsintaweekul; Kayoko Abe; Rintaro Koga; Yoshinori Katakura; Kohei Torikai

doi:10.22146/ijc.53411

Antimicrobial and Anti-Oxidative Activities of 12-Arylbenzoacridines

https://doi.org/10.22146/ijc.53411

Boonsong Wungsintaweekul^(1*), Kayoko Abe⁽²⁾, Rintaro Koga⁽³⁾, Yoshinori Katakura⁽⁴⁾, Kohei Torikai⁽⁵⁾

(1) School of Pharmacy, Walailak University, 222 Thaiburi, Thasala, Nakhon Si Thammarat 80161, Thailand
(2) Graduate School of Systems Life Sciences, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
(3) Department of Chemistry, Graduate School and Faculty of Science, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
(4) Faculty of Agriculture, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
(5) Department of Chemistry, Graduate School and Faculty of Science, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan
(*) Corresponding Author

Abstract

Searching biologically active compounds has been one of the major duties of organic chemists. We previously constructed a library of synthetic 12-arylbenzoacridines and found estrogenic and anti-estrogenic agents. With taking the shot-gun approach into consideration, further exploration for bioactive species in the above library was carried out. As a result, new antibacterial agents against S. aureus (MIC = 16 μM), E. coli (MIC = 7.8 μM), E. faecalis (MIC = 0.98 μM), and A. baumannii (MIC = 31 μM) were found. Moreover, we also unveiled that some of the tested compounds exhibit cell-based anti-oxidative activity. These results clearly show a good potential of 12-arylbenzoacridines as novel pharmacophores, which is useful to establish various medicines.

Keywords

benzoacridine; antibacterial; shotgun approach; antioxidant

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DOI: https://doi.org/10.22146/ijc.53411