A PRENYLATED FLAVONE FROM THE HEARTWOOD OF Artocarpus scortechinii King (Moraceae)
Aliefman Hakim(1*)
(1) Study Program of Chemistry Education, Faculty of Teacher Training and Education, University of Mataram Jl. Majapahit 62 Mataram, Indonesia
(*) Corresponding Author
Abstract
Two prenylated flavones have been successfully isolated from the methanol extract of the heartwood Artocarpus scortechinii King. They were determined as artelastisin and artelastin. It has been reported that artelastisin and artelastin were obtained from Artocarpus elasticus. The cytotoxicity toward cell murine leukemia P-388 showed that artelastisin is active with IC50 3.0 µg/mL. In addition, artelastin is inactive with IC50 5.75 µg/mL. The structures of isolated compounds were determined based on spectroscopy data including UV, IR, 1H and 13C-NMR. These compounds are reported for the fist time from this plant.
Keywords
Full Text:
Full Text PDFReferences
[1] Achmad, S.A., Hakim, E.H., Juliawaty, L.D., Makmur, L., Kusuma, S., and Syah, Y.M., 1995, Eksplorasi Kimia Tumbuhan Tropis Indonesia, Seminar Nasional Etnobotani II, Yogyakarta, 112-113.
[2] Heyne, K., 1987, Tumbuhan Berguna Indonesia II, Terjemahan, Penerbit Badan Litbang Kehutanan, Jakarta, 645-646.
[3] Nomura, T., Hano, S., and Aida M., 1998, Heterocycles, 47 (2), 1179-1205.
[4] Syah, Y.M., Achmad, S.A., Ghisalberti, E.L., Hakim, E.H., Makmur, L., and Mujahidin, D., 2002, Artoindonesianins Q–T, four isoprenylated flavones from Artocarpus champeden Spreng. (Moraceae), Phytochemistry, 61, 949-953.
[5] Hakim, E.H., Achmad, S.A., Juliawaty, L.D., Makmur, L., Syah, Y.M., Aimi N., Kitajima, M., Takayama, H., and Ghisalberti, E.L., 2006, J. Nat. Med., 60, 161–184.
[6] Alley, M.C., Dominic A., Scudiere, Anne M., Miriam L.H., Maciej, J., Czerwinski, Donald L.F., Betty J.A., Joseph G.M., Robert H.S., and Boyd, M.R., 1988, Cancer Res., 48, 589-601.
[7] Kijjoa, A., Cicade, H.M., Pinto, M.M.M., Gonzales, M.J.T.G., Anantachoke, C., Gedris T.C., and Herz W. 1996, Phytochemistry, 43 (3), 681-689.
DOI: https://doi.org/10.22146/ijc.21577
Article Metrics
Abstract views : 2001 | views : 6039Copyright (c) 2010 Indonesian Journal of Chemistry
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Indonesian Journal of Chemistry (ISSN 1411-9420 /e-ISSN 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.
View The Statistics of Indones. J. Chem.