* Corresponding Author
ANTI DIABETIC FLAVANONE COMPOUND FROM THE LEAVES OF Artocarpus communis
https://doi.org/10.22146/ijc.21524 Puspa D.N. Lotulung(1*), Sofa Fajriah(2), Andini Sundowo(3), Euis Filaila(4)
(1) Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK, Serpong, Tangerang, Banten
(2) Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK, Serpong, Tangerang, Banten
(3) Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK, Serpong, Tangerang, Banten
(4) Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPIPTEK, Serpong, Tangerang, Banten
(*) Corresponding Author
Abstract
The Flavanone compound with anti diabetic activity was isolated from ethyl acetate extract of Artocarpus communis leaves using column chromatography techniques. The structure of the flavanone compound was elucidated on the basic of spectroscopic evidence and comparison to published values. This compound, 8-geranyl-4,5,7-trihydroxyflavone, showed strong anti diabetic activity on α-glucosidase inhibition assay with IC50 18.120 µg mL-1.
Keywords
Full Text:
Full Text PDFReferences
[1] Corry, D.B., and Tuck M.L., 2000, Curr. Hypertens. Rep., 2,154-9.
[2] Sratton, I.M., Adler, A.I., Neil, H.A., Matthews, D.R., Manley, S.E., Cull, C.A., 2000, Br. Med. J., 321, 405-12.
[3] Zimmet, P., Alberti, K., and Shaw, J., 2001, Nature, 414, 782-787.
[4] slagle, m., 2004, South Med. J., [cited 2004 June 18], http://static.highbem.com/s/southernmedicaljournal/january012002/alphaglucosideinhibitorsmedicationupdatebriefart/index.html
[5] Bayer, 2004, precose (Acarbose Tablets). http://www.drugs.com/PDR/Precose/Tablets.html
[6] Jarvill-Taylor, K.J., Anderson, R.A., and Graves, D.J., 2001, J. Am. Coll. Nutr., 20, 4, 327-336.
[7] Maroo, J., Vasu, V.T., Aalinkeel, R., and Gupta, S., 2002, J. Ethnopharmacol., 81, 317-320.
[8] Elder, C., 2003, Altern. Ther. Health Med., 10, 1, 44-50.
[9] Grover, J.K., Yadav, S., and Vats, V., 2002, J. Ethnopharm., 81, 81-100.
[10] Dawra, R.K., Makkar, H.P., and Singh, B., 1988, Anal. Biochem., 170, 1, 50-53.
[11] Suryanarayana, P., Kumar, P.A., Saraswat, M., Petrash, J.M., and Reddy, G.B., 2004, Mol. Vision, 10, 148-154.
[12] Hanefeld, M., and Temelkova-Kurktschiev, T., 2002, Nutr. Metab. Cardiovasc. Dis., 12, 98-107.
[13] Vats V., Grover, J.K., and Rathi, S.S., 2002, J. Ethnopharm., 79, 95-100.
[14] McCue, P., and Shetty, K., 2004, J. Clin. Nutr., 13, 1, 101-106
[15] McCue, P., Vatten, D., and Shetty K., 2004, J. Clin. Nutr., 13, 4, 401-408.
[16] Lemmens, R.H.M.J., Soerianegara, I., and Wong, W.C., editors, 1995, Plant resources of South-East Asia No. 5 (2), timber trees: minor commercial timbers. Indonesia: Prosea Bogor. ISBN Number: 979-8316-18-5
[17] Nomura, T., Hano, Y., and Aida, M., 1998, Heterocycles., 47, 1179-1205.
[18] Boonlaksiri, C., Oonanant, W., Kongsaeree, P., Kittakoop, P., Tanticharoen, M., and Thebtaranonth, Y., 2000, Phytochem., 54, 415-417.
[19] Likhitwitayawuid, K. and Sritularak, B., 2001, J. Nat. Prod., 64, 11, 1457-1459.
[20] Shimizu, K., Fukuda, M., Kondo, R., and Sakai, K., 2000, Planta Med., 66, 1, 16-19.
[21] Shimizu, K., Kondo, R., Sakai, K., Lee, S.H., and Sato, H., 1998, Planta Med., 64, 408-412.
[22] Lee, D.S. and S.H. Lee., 2001, FEBS Lett., 501, 84-86.
[23] Koshihara, Y., Fujimoto, Y., and Inoue, H., 1988, Biochem. Pharmacol., 37, 2161-2165.
[24] McLean, S., Reynolds, W.F., Tinto, W.F., Chan, W.R., and Shepherd, V., 1996, Magn. Reson. Chem., 34, 719-722.
DOI: https://doi.org/10.22146/ijc.21524
Article Metrics
Abstract views : 1369
| 
views : 1132
Copyright (c) 2010 Indonesian Journal of Chemistry
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Indonesian Journal of Chemistry (ISSN 1411-9420 /e-ISSN 2460-1578) - Chemistry Department, Universitas Gadjah Mada, Indonesia.