Prevalensi infeksi virus Hepatitis B pada bayi dan anak yang dilahirkan ibu dengan HBsAg positif

https://doi.org/10.22146/bkm.26310

Nasir Ahmad(1*), Hari Kusnanto(2)

(1) Departemen Biostatistik, Epidemiologi dan Kesehatan Populasi, Fakultas Kedokteran, Universitas Gadjah Mada
(2) Departemen Biostatistik, Epidemiologi dan Kesehatan Populasi, Fakultas Kedokteran, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Purpose

This study aimed to examine the prevalence rate of Hepatitis B Virus (HBV) infection in infants aged more than 9 months born to HbsAg-positive mothers as well as the distribution of the cases in Magelang Regency for the years 2014-2016.

Method

The study used a survey approach with total sampling. The sample of this research consisted of infants aged more than 9 months born to HBsAG-positive mothers diagnosed from laboratory examination (Rapid Diagnostic Test) based on the report from the Health Office of Magelang Regency for the years 2014-2016. The method of analysis used was descriptive. The HBsAg of the sample was examined using HBsAg Rapid Test Cassette and confirmed using Enzyme-Linked Fluorescence Assay (ELFA) methods at a laboratory.

Results

The prevalence rate of Hepatitis B virus infection in infants born to HBsAG-positive mothers in Magelang Regency was 0 percent (0/61). The history of the administration of HB0 vaccine <12 hours to respondents reached 100 percent and the history of the administration of HBIg <12 hours was 68.85 percent. The history of respondents’ caesarean delivery was 37.7 percent. The history of therapy of respondents was by giving curcuma and Java ginger (temulawak). The price of HBIg is relatively expensive Rp. 1,000,000 – Rp. 4,999,999.

Conclusion

This study concludes that there was no vertical transmission with 100 percent history of the administration of HB0 vaccine.


Keywords


HBV; Hepatitis B; incidence; HBsAg



References

  1. Health Protection Surveillance Centre. Guidelines for the Emergency Management of Injuries. Ireland: Health Protection Surveillance Centre; 2012.
  2. CDC. Hepatitis B Information; 2016. Available at: http://www.cdc.gov/Hepatitis/hbv/ [Accessed Oktober 1, 2016].
  3. WHO. Hepatitis B; 2016. Available at: http://www.who.int/mediacentre/factsheets/fs204/en/ [Accessed Oktober 1, 2016].
  4. Infodatin. Situasi dan Analisis Hepatitis. Jakarta: Kementrian Kesehatan Republik Indonesia; 2014.
  5. CDC. Hepatitis B. Atlanta: Centers for Disease Control and Prevention; 2010.
  6. WHO. Hepatitis B. World Health Organization; 2002.
  7. Litbangkes. Riset Kesehatan Dasar 2007. Jakarta: Kementrian Kesehatan Republik Indonesia; 2007.
  8. Litbangkes. Riset Kesehatan Dasar 2013. Jakarta: Kementrian Kesehatan Republik Indonesia; 2013.
  9. Kemenkes RI. Pedoman Pengendalian Hepatitis Virus. Jakarta: Kementrian Kesehatan Republik Indonesia; 2012.
  10. Dinkes Kabupaten Magelang. Laporan Kesehatan Ibu 2016. Kota Mungkid: Dinas Kesehatan Kabupaten Magelang; 2016.
  11. Kemenkes RI. Kemenkes RI Lakukan Pengendalian Penyakit Hepatitis di Indonesia; 2013. Available at: http://www.depkes.go.id/ [Accessed Oktober 1, 2016].
  12. Varney. Buku Ajar Asuhan Kebidanan. Jakarta: EGC; 2006.
  13. IDAI, Satgas Imunisasi. Jadwal imunisasi rekomendasi IDAI. Sari Pediatri. 2000;2(1): 43-7.
  14. Biotest. Rightsign HBsAg Rapid test Cassette. Hangzhou: Hangzhou Biotest Co; 2015.
  15. Yolken, R. H., & Stopa, P. J. Enzyme-linked fluorescence assay: Ultrasensitive solid-phase assay for detection of human rotavirus. Journal of clinical microbiology. 1979;10(3), 317-321.
  16. Dwivedi, M., Misra, S. P., Misra, V., Pandey, A., Pant, S., Singh, R., & Verma, M. Seroprevalence of Hepatitis B infection during pregnancy and risk of perinatal transmission; 2011.
  17. American College of Obstetricians and Gynecologists. ACOG Practice Bulletin No. 86: Viral Hepatitis in pregnancy. Obstetrics and gynecology. 2007;110(4), 941.
  18. Shepard, C. W., Simard, E. P., Finelli, L., Fiore, A. E., & Bell, B. P. Hepatitis B virus infection: epidemiology and vaccination. Epidemiologic reviews. 2006;28(1), 112-125.
  19. Lu, Y., Liang, X. F., Wang, F. Z., Yan, L., Li, R. C., Li, Y. P., ... & Zhuang, H. Hepatitis B vaccine alone may be enough for preventing Hepatitis B virus transmission in neonates of HBsAg (+)/HBeAg (−) mothers. Vaccine. 2017;35(1), 40-45.
  20. Beasley, R. P., George, C. Y. L., Roan, C. H., Hwang, L. Y., Lan, C. C., Huang, F. Y., & Chen, C. L. Prevention of perinatally transmitted Hepatitis B virus infections with Hepatitis B immune globulin and Hepatitis B vaccine. The Lancet. 1983;322(8359), 1099-1102.
  21. Kang, G., Ma, F., Chen, H., Yang, Y., Guo, S., Wang, Z., ... & Zhang, L. Efficacy of antigen dosage on the Hepatitis B vaccine response in infants born to Hepatitis B-uninfected and Hepatitis B-infected mothers. Vaccine. 2015; 33(33), 4093-4099.
  22. Kiire, C. F. The epidemiology and prophylaxis of Hepatitis B in sub-Saharan Africa: a view from tropical and subtropical Africa. Gut. 1996;38(Suppl 2), S5-12.
  23. Yeoh, E. K., Chang, W. K., Ip, P., Chan, K. H., Chan, E., & Fung, C. Efficacy and safety of recombinant Hepatitis B vaccine in infants born to HBsAg-positive mothers. Journal of Infection. 1986;13, 15-18.
  24. Chen, S. M., Kung, C. M., Yang, W. J., & Wang, H. L. Efficacy of the nationwide Hepatitis B infant vaccination program in Taiwan. Journal of Clinical Virology. 2011;52(1), 11-16.
  25. Pan, C. Q., Zou, H. B., Chen, Y., Zhang, X., Zhang, H., Li, J., & Duan, Z. Cesarean section reduces perinatal transmission of Hepatitis B virus infection from Hepatitis B surface antigen–positive women to their infants. Clinical Gastroenterology and Hepatology. 2013;11(10), 1349-1355.
  26. Infopom. Gerakan Nasional Minum Temulawak. Jakarta: BPOM RI; 2005.
  27. Kim, H. J., Yoo, H. S., Kim, J. C., Park, C. S., Choi, M. S., Kim, M., & Ahn, J. K. Antiviral effect of Curcuma longa Linn extract against Hepatitis B virus replication. Journal of ethnopharmacology. 2009;124(2), 189-196.



DOI: https://doi.org/10.22146/bkm.26310

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