Faktor risiko loss to follow up terapi ARV pada pasien HIV

https://doi.org/10.22146/bkm.12732

Listy Handayani(1*), Riris Andono Ahmad(2), Yanri Wijayanti Subronto(3)

(1) Departmen Biostatistik, Epidemiologi, dan Kesehatan Populasi, Fakultas Kedokteran, Universitas Gadjah Mada
(2) Departmen Biostatistik, Epidemiologi, dan Kesehatan Populasi, Fakultas Kedokteran, Universitas Gadjah Mada
(3) Departemen Ilmu Penyakit Dalam, Fakultas Kedokteran, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Risk factors for loss to follow up of antiretroviral therapy in HIV patients

Purpose

This study aimed to determine risk factors for loss to follow-up of antiretroviral therapy among HIV-infected patients in Dr. Sardjito Yogyakarta, 2011-2014.

Methods

A retrospective cohort study was conducted involving 499 HIV patients. Observations were conducted for four years using medical records. Data analysis was performed using Kaplan-Meier and Cox proportional hazards regression tests.

Results

There were 190 loss to follow-up patients. Risk factors for loss to follow-up of ARV therapy were: a student (AHR = 2.42; 95% CI = 1.20-4.89), the distance ≥ 10 km (AHR = 1.58; 95% CI = 1:09 to 2:31), using health insurance (AHR = 1.67; 95% CI = 1:11 to 2:51) and homosexual as a protective factor of loss to follow-up of antiretroviral therapy (HR = 0:49; 95% CI = 0.30-0.80).

Conclusion

Being a college student, the distance between home and ARV service ≥10 km and using health insurance were the risk factors for loss to follow-up of ARV treatment. Adherence counseling for students, cooperation with the drug taking supervisor and decentralization ARV service, as well as effective and efficient services for patients who use health insurance need to be strengthened.


Keywords


loss to follow-up; ARV; HIV



References

  1. WHO. 10 Facts on HIV/AIDS. Available at: http://www.who.int/features/factfiles/hiv/en/. [Diakses 29 Juli 2016].
  2. Ditjen PP & PL Kemenkes RI. (2015). Laporan Perkembangan Pengendalian HIV-AIDS Triwulan III. Jakarta: Kemenkes RI. 2015.
  3. KPA Provinsi DIY. (2015). Data Kasus HIV & AIDS DIY s.d. Triwulan 1 Tahun 2015, Available at: http://aidsyogya.or.id/category/data-hiv-aids/. [Diakses 29 Juli 2016].
  4. Permenkes RI No. 87 Tahun 2014 tentang Pedoman Pengobatan Antiretroviral. Kemenkes RI. Jakarta.
  5. Hønge BL, Jespersen S, Nordentoft PB, Medina C, da Silva D, da Silva ZJ, Østergaard L, Laursen AL, Wejse C, Bissau HIV cohort study group. Loss to follow-up occurs at all stages in the diagnostic and follow-up period among HIV-infected patients in Guinea-Bissau: a 7-year retrospective cohort study. BMJ open. 2013 Oct 1;3(10):e003499. Available at: http://www.ncbi.nlm.nih.gov [Diakses 28 Desember 2015].
  6. Odafe S, Idoko O, Badru T, Aiyenigba B, Suzuki C, Khamofu H, Onyekwena O, Okechukwu E, Torpey K, Chabikuli ON. Patients’ demographic and clinical characteristics and level of care associated with lost to follow‐up and mortality in adult patients on first‐line ART in Nigerian hospitals. Journal of the International AIDS Society. 2012 Apr 1;15(2). Available at: http://www.jiasociety.org/. [Diakses 14 Desember 2015].
  7. Bekolo CE, Webster J, Batenganya M, Sume GE, Kollo B. Trends in mortality and loss to follow-up in HIV care at the Nkongsamba Regional hospital, Cameroon. BMC research notes. 2013 Dec;6(1):512. Available at: http://www.biomedcentral.com/ [Diakses 7 September 2015].
  8. Zhou J, Tanuma J, Chaiwarith R, Lee CK, Law MG, Kumarasamy N, Phanuphak P, Chen YM, Kiertiburanakul S, Zhang F, Vonthanak S. Loss to followup in HIV-infected patients from Asia-Pacific region: Results from TAHOD. AIDS research and treatment. 2012;2012.. Available at: http://www.hindawi.com/ [Diakses 28 Desember 2015].
  9. Mahardining AB. Hubungan Antara Pengetahuan, Motivasi, Dan Dukungan Keluarga Dengan Kepatuhan Terapi Arv Odha. KEMAS: Jurnal Kesehatan Masyarakat. 2010;5(2). Available at: http://www.journal.unnes.ac.id.
  10. Widyanthini DN. Faktor-Faktor Yang Berhubungan Dengan Loss To Follow Up Pada ODHA Yang Menerima Terapi ARV Di Klinik Amertha Yayasan Kerti Praja Bali Tahun 2002-2012. Skripsi. Denpasar: Universitas Udayana. Available at: http://www.pps.unud.ac.id/[Diakses 24 Mei 2015].
  11. Togun T, Peterson I, Jaffar S, Oko F, Okomo U, Peterson K, Jaye A. Pre-treatment mortality and loss-to-follow-up in HIV-1, HIV-2 and HIV-1/HIV-2 dually infected patients eligible for antiretroviral therapy in The Gambia, West Africa. AIDS research and therapy. 2011 Dec;8(1):24. Available at: http://www.ncbi.nlm.nih.gov/ [diakses 28 Desember 2015].
  12. Ubra RR. Faktor-faktor yang Berhubungan dengan Kepatuhan Pengobatan Minum ARV pada Pasien HIV di Kabupaten Mimika–Provinsi Papua Tahun 2012. Universitas Indonesia. 2012.
  13. Saka B, Landoh DE, Patassi A, d’Almeida S, Singo A, Gessner BD, Pitché PV. Loss of HIV-infected patients on potent antiretroviral therapy programs in Togo: risk factors and the fate of these patients. Pan African Medical Journal. 2013;15(1). Available at: http://www.panafrican-med-journal.com/ [Diakses 28 Desember 2015].
  14. Ochieng-Ooko V, Ochieng D, Sidle JE, Holdsworth M, Wools-Kaloustian K, Siika AM, Yiannoutsos CT, Owiti M, Kimaiyo S, Braitstein P. Influence of gender on loss to follow-up in a large HIV treatment programme in western Kenya. Bulletin of the World Health Organization. 2010;88:681-8. Available at: http://www.ncbi.nlm.nih.gov/. [Diakses 7 September 2015].
  15. Sasaki Y, Kakimoto K, Dube C, Sikazwe I, Moyo C, Syakantu G, Komada K, Miyano S, Ishikawa N, Kita K, Kai I. Adherence to antiretroviral therapy (ART) during the early months of treatment in rural Zambia: influence of demographic characteristics and social surroundings of patients. Annals of clinical microbiology and antimicrobials. 2012 Dec;11(1):34. Available At: http://www.ann-clinmicrob.com/ [Diakses 22 Juli 2016].
  16. Krishnan S, Wu K, Smurzynski M, Bosch RJ, Benson CA, Collier AC, Klebert MK, Feinberg J, Koletar SL, ALLRT/A5001 Team. Incidence rate of and factors associated with loss to follow-up in a longitudinal cohort of antiretroviral-treated HIV-infected persons: an AIDS Clinical Trials Group (ACTG) Longitudinal Linked Randomized Trials (ALLRT) analysis. HIV clinical trials. 2011 Aug 1;12(4):190-200. Available at: http://www.ncbi.nlm.nih.gov/ [Diakses 28 Desember 2015].
  17. Amberbir A, Woldemichael K, Getachew S, Girma B, Deribe K. Predictors of adherence to antiretroviral therapy among HIV-infected persons: a prospective study in Southwest Ethiopia. BMC Public Health. 2008 Dec;8(1):265. Available at: http://www.biomedcentral.com/1471-2458/8/265. [Diakses 7 September 2015].
  18. Shaweno T, Shaweno D. When are patients lost to follow-up in pre-antiretroviral therapy care? a retrospective assessment of patients in an Ethiopian rural hospital. Infectious diseases of poverty. 2015 Dec;4(1):27. Available at: http://www.ncbi.nlm.nih.gov/. [Diakses 24 September 2015].
  19. Govindasamy D, Ford N, Kranzer K. Risk factors, barriers and facilitators for linkage to antiretroviral therapy care: a systematic review. Aids. 2012 Oct 23;26(16):2059-67. Available at: http://www.ncbi.nlm.nih.gov/ [Diakses 7 September 2015].
  20. Geng EH, Bangsberg DR, Musinguzi N, Emenyonu N, Bwana MB, Yiannoutsos CT, Glidden DV, Deeks SG, Martin JN. Understanding reasons for and outcomes of patients lost to follow-up in antiretroviral therapy programs in Africa through a sampling-based approach. Journal of acquired immune deficiency syndromes (1999). 2010 Mar;53(3):405., Available at: http://www.ncbi.nlm.nih.Gov/pmc/articles/PMC3606953/. [Diakses 22 Juli 2016].
  21. KPAN-UNAIDS.Penelitian Partisipatif: ODHA & Akses Pelayanan Kesehatan Dasar. 2005. Available at: http://spiritia.or.id/Dok/odhaakses.pdf. [Diakses 6 Agustus 2016].
  22. Hermanides H, Holman R, Gras L, Winkel C, Gerstenbluth I, de Wolf F, Duits A. Loss to follow-up and mortality rates in HIV-1-infected patients in Curaçao before and after the start of combination antiretroviral therapy. AIDS research and human retroviruses. 2013 Oct 1;29(10):1300-5. Available at: http://www.rug.nl/. [Diakses 24 September 2015].
  23. Tadesse K, Fisiha H. Predictors of Loss to Follow Up of Patients Enrolled on Antiretroviral Therapy: A Retrospective Cohort Study. J AIDS Clin Res. 2014;5(393):2. Available at: http://dx.doi.org/10.4172/2155-6113.1000393. [Diakses 24 September 2015].
  24. Mberi MN, Kuonza LR, Dube NM, Nattey C, Manda S, Summers R. Determinants of loss to follow-up in patients on antiretroviral treatment, South Africa, 2004–2012: a cohort study. BMC health services research. 2015 Dec;15(1):259. Available at: http://www.ncbi.nlm.nih.gov/
  25. Elzi L, Marzolini C, Furrer H, Ledergerber B, Cavassini M, Hirschel B, Vernazza P, Bernasconi E, Weber R, Battegay M. Treatment modification in human immunodeficiency virus–infected individuals starting combination antiretroviral therapy between 2005 and 2008. Archives of internal medicine. 2010 Jan 1;170(1):57-65.



DOI: https://doi.org/10.22146/bkm.12732

Article Metrics

Abstract views : 4437 | views : 2873

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2017 Berita Kedokteran Masyarakat

Creative Commons License
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.

Berita Kedokteran Masyarakat ISSN 0215-1936 (PRINT), ISSN: 2614-8412 (ONLINE).

Indexed by:

 

Web Analytics Visitor Counter