Comparison between plasma lactate and lactate clearance with the impact of acute phase complication in burn injury patient

Abstract

Severe burn can cause rapid loss of intravascular volume with resultant a
decrease in peripheral blood flow which reduces tissue oxygen transport and in
turn, increases plasma lactate. Plasma lactate and lactate clearance are useful
parameters to compare complicated and uncomplicated burn patients in the
acute phase. The study aimed to evaluate the initial and 24-h plasma lactate
levels as well as lactate clearance as useful parameters to assess acute phase
complications of burn patients. This was a cross-sectional study involving
35 burn patients who admitted at Abdul Wahab Sjahranie District Hospital,
Samarinda during the period of September 2018 to September 2019. The
study was immediately begun after admission of the patients. Plasma lactate
levels were measured at admission and24-h after the first measurement. The
acute phase complication was assessed 72 h after burns from the laboratory
parameter. Fisher’s exact test and t test using SPSS software version 24were
applied for statistical analysis. The 24-h plasma lactate level (p= 0.001) and
plasma lactate clearance (p = 0.002) were significantly correlated with the
occurrence of acute phase complications of burns. However, the initial plasma
lactate level was not significantly correlated (p = 0.609). In conclusion, there is
a significantly correlation between 24-h plasma lactate level and plasma lactate
clearance are with the occurrence of acute phase complications of burns.