The effect of 0.03% flurbiprofen and 0.1% indomethacin eye drops and oral indomethacin on the pupil diameter in the extracapsular cataract surgery

Abstract

Background: Intraocular surgery releases prostaglandin. Prostaglandin caused miosis and inflammatory reaction. Flurbiprofen and Indomethacin are antiprostaglandin agents.
Objectives: This study was aimed to compare the effects of flurbiprofen and indomethacin eye drop and flurbiprofen tablet orally in preventing surgically induced miosis to dilated pupils during extracapsular cataract surgery.
Methods: Measurement of the diameter of dilated pupil before and during extracapsular cataract surgery. Analysis variance and Tukey Studentized Rest Test were used to analyse the result.
Results: No statitical significant difference was found in pupil diameter among the three groups except the stage of capsulotomy and inspiration-aspiration among those who received flurbiprofen and indomethacin eye drops.
Conclusion: Flurbiprofen 0.03% eye drop was significantly stronger than Indomethacine eye drop 0.1% in preventing surgically induced miosis at extracapsular cataract surgery especially in both stage of capsulotomy and inspiration-aspiration and type manipulation.

Keywords: cataract surgery - anterior capsulotomy - lens extraction - insiparition-aspiration - miosis -antiprostaglandin