Comparing P-Selectin (CD62P) expression in patients receiving non-leukodepleted vs leukodepleted thrombocyte concentrates

https://doi.org/10.19106/JMedSci004903201704

Teguh Triyono(1*), Budi Mulyono(2), . Sutaryo(3), Abdul Salam Sofro(4)

(1) Departement of Clinical Pathology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta
(2) Departement of Clinical Pathology, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta
(3) Departement of Pediatry, Faculty of Medicine, Universitas Gadjah Mada,
(4) Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia
(*) Corresponding Author

Abstract


Thrombocyte concentrate (TC) transfusion is an important supportive therapy in patients with thrombocytopenia. The risks in platelet transfusions may be related to the content of TC including the contaminant leukocytes. The aim of this study was to assess the risk of increased level of P-Selectin (CD62P) expression of non-leukodepleted TC transfusions.This was a quasi-experimental study. Subjects were children patients aged 1-18 years who received a non-leukodepleted or a leukodepleted TC transfusions. Comparison of the proportion of  increased expression of CD62P in both groups expressed as relative risk. The subjects consisted of 51 patients who received non-leukodepleted and 52 patients who received leukodepleted TC transfusions. The risk of increased expression of CD62P in patients receiving non-leukodepleted TC transfusions were 2.38 (95%CI:1.60-3.53) times higher than those who received leukodepleted TC. Non-leukodepleted have significant higher risks of increased CD62P expression than leukodepleted  TC transfusions.

Keywords


thrombocyte conentrate – transfusion – CD62P expression - thrombocytopenia – adverse effect

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References

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DOI: https://doi.org/10.19106/JMedSci004903201704

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