Calophyllum inophyllum: A Comprehensive Analysis of its Ethnobotanical, Phytochemical, and Pharmacological Properties

https://doi.org/10.22146/mot.87488

Sofa Farida(1), Riris Istighfari Jenie(2), Nanang Fakhrudin(3*)

(1) *) Master of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Sleman 55281, Yogyakarta *) Research Center for Pharmaceutical Ingredient and Traditional Medicine, National Agency of Research and Innovation, Cibinong, Bogor 16915, West Java
(2) *) Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Universitas Gadjah Mada, Sleman 55281, Yogyakarta *) Cancer Chemoprevention Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Sleman 55281
(3) *) Department of Pharmaceutical Biology, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Sleman 55281, Yogyakarta *) Medicinal Plants and Natural Products Research Center, Faculty of Pharmacy, Universitas Gadjah Mada, Sekip Utara, Sleman 55281, Yogyakarta
(*) Corresponding Author

Abstract


Nyamplung (Calophyllum inophyllum L.) is reported to have ethnomedicinal benefits in traditional medicine systems. Leaves, fruit, seeds, flowers, stems, roots and essential oils are the parts that are often used. Previous scientific studies revealed that this plant part is a valuable resource of secondary metabolites and exhibits a wide range of biological activities. The purpose of this review is to deliver thorough and detailed insights into the traditional uses, chemical ingredients, biology, and pharmacological studies as scientific evidence about the useful efficacy of C. inophyllum in the development of modern medicine. Traditional use shows C. inophyllum is widely used to treat skin diseases, wounds, boils, vaginal discharge, bleeding, gonorrhea, chronic bronchitis, sore eyes, heatstroke, and headaches. C. inophyllum is rich in phenols, polyphenols, flavonoids, xanthones, coumarins, and terpenoids. Several research results show that C. inophyllum possesses a multitude of pharmacological properties including anti-cancer, anti-inflammatory, antimicrobial, antioxidant, antiplatelet, antiviral, and antidiabetic activities.


Keywords


Tamanu; biological activity; secondary metabolites; ethnopharmacology; drug discovery;

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DOI: https://doi.org/10.22146/mot.87488

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