FORMULA OPTIMATION OF SENGGUGU ROOT BARK EXTRACT LOZENGES (Clerodendrum serratum (L.) Moon.) AS MUCOLYTIC AGENT WITH LACTOSE – SORBITOL FILLER COMBINATION

https://doi.org/10.22146/tradmedj.8075

Wahyono Wahyono(1*), Luthfia Hanifah Kurniati(2), TN Saifullah Sulaiman(3)

(1) Faculty of Pharmacy, Universitas Gadjah Mada
(2) Faculty of Pharmacy, Universitas Gadjah Mada
(3) Faculty of Pharmacy, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Senggugu root bark has mucolytic activity and has been used empirically, so it needs to be formulated as lozengeswhich can be used practically and comfortable for the patients. Senggugu root bark powder was extracted by maceration using aethanol 70%. Lozenges was optimized using lactose-sorbitol filler mix through three formulas, formula A ( 100% lactose), formula B (100% sorbitol), formula C (50% lactose-50% sorbitol). Lozenges was made by wet granulation method. The optimum formula was obtained from theresults of physical granul test and lozenges using SLD, and analyzed by its granul flow, hardness, dissolution time, and taste responsiveness, and also qualitative and quantitative analysis. The results show that lactose-sorbitol filler mix can increase hardness and taste responsiveness, decrease granul flow and dissolution time. The oprimum formula from this research is 100% sorbitol:0% lactose.

 


Keywords


senggugu, lactose, sorbitol, simplex lattice design, lozenges



References

Ansel, H. C., 1989, Pengantar Bentuk Sediaan Farmasi, Edisi IV, 225-271, 607-608, UI Press, Jakarta

Banker, G. S., and Anderson, N.R., 1986, Tablet, in Lachman, L., Lieberman, H.A., and Kanig, J. L. (Eds.), The Theory and Practise of Industrial Pharmacy, 3rd Ed., 683-703, UI Press, Jakarta

Cooper, J. W., and Gunn, C., 1975, Dispensing for Pharmaceutical Student,6th Ed., 186-202, Pitman Medical Publishing Co., Ltd., London

Gunsel, W.C., and Kanig, J.L., 1976, Tablet, in Lachman, L., Lieberman, H.A., and Kanig, J.L. (Eds.), The Theory and Practice of Industrial Pharmacy, 2nd Ed., 321, 327-329, Lea and Febinger, Philadelphia

Harborne, J.B., 1984, Metode Fitokimia : Penuntun Cara Modern Menganalisis Tumbuhan, diterjemahkan oleh Kosasih Padmawinata dan Iwang Soediro, Edisi II, 70-72, Penerbit ITB, Bandung

Haslinda, 1999, Uji Aktivitas Mukolitik Ekstrak Kulit Akar Senggugu (Clerodendrum serratum Spreng) Secara Invitro dan Identifikasi Senyawa Utamanya, Skripsi, Fakultas Farmasi Universitas Gadjah Mada, Yogyakarta

Robinson, T., 1995, Kandungan Organik Tumbuhan Tinggi, diterjemahkan oleh Kosasih Padmawinata, 191 – 213, Penerbit ITB, Bandung

Sastrohamidjojo, H., 2002, Kromatografi, Edisi II, 6-18, Penerbit Liberty, Yogyakarta

Wahyono, 1998, Isolasi Senyawa Bioaktif dari Kulit Akar dan Kulit Batang Clerodendron serratum Spreng yang Berkhasiat Sebagai Mukolitik, Laporan Penelitian, Universitas Gadjah Mada, Yogyakarta

Wahyono, 2004, Isolasi dan Karakterisasi Senyawa Berkhasiat Trakeospasmolitik dari Kulit Akar Senggugu (Clerodendron serratum Spreng), Laporan Penelitian Que Project Fakultas Farmasi, Universitas Gadjah Mada, Yogyakarta



DOI: https://doi.org/10.22146/tradmedj.8075

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