LOZENGES FORMULATION OF MIXED EXTRACT OF Curcuma xanthorrhiza Roxb AND Kaempferia galanga L USING COMBINATION OF FILLER AGENTS MANITOL – MALTODEXTRIN

https://doi.org/10.22146/tradmedj.7748

Widodo Ndaru Prasetyo(1), Mufrod Mufrod(2*)

(1) Faculty of Pharmacy, Universitas Gadjah Mada
(2) Faculty of Pharmacy, Universitas Gadjah Mada
(*) Corresponding Author

Abstract


Mixture of temulawak and kencur is usually used to increase appetite, but the usual dosage form is less practical and unstable. It is therefore will be better to make it into lozenges, that will be more practical and acceptable. This research aims to determine the effect of filler agent manitol-maltodextrin variations to the physical characteristics of granule, tablet, and the flavor of the tablet. The extracts of temulawak and kencur were made by percolation using ethanol 70%, wet granulated, and made for three formulas of combination manitol-maltodextrin (100:0, 85:15, 70:30). Results showed that the combination of manitol-maltodextrin had affected the time of flow, physical behavior of granule and lozenges compactibility, except for appearance test. The result of flavor test showed respondents stated formula I was sour, and the formula II and III were bitter.

Keywords


C. xanthorrhiza, K. galanga, filler agent, lozenges



References

Anonim, 1985. Tanaman Obat Indonesia I. Departemen Kesehatan RI, Jakarta. 45

Anonim, 1979. Farmakope Indonesia, Edisi III. Departemen Kesehatan Republik Indonesia, Jakarta. 654

Anwar, E., Joshita, Yanuar, A., Bahtiar, A. 2004. Pemanfaatan Maltodextrin Pati Terigu Sebagai Eksipien dalam Formulasi Sediaan Tablet dan Niosom. Majalah Ilmu Farmasi.1: 34-37

Armstrong, N.A. 2006. Gelatin, Magnesium stearat, Asam sitrat, Laktosa, in Rowe, R.C., Sheskey, P.J., Owe, S.C., (Eds.). 2006. Handbook of Pharmaceutical Excipients, American Pharmaceutical Association, Washington DC. 185-187, 295-298, 430-433, 385-388

Puryanto, W. 2004. Dosis Efektif Campuran Suspensi Ekstrak Etanolik Temulawak dan Kencur terhadap Peningkatan BB Tikus Putih Jantan Wistar serta Identifikasi Kandungan Kimianya, Skripsi, Universitas Gadjah Mada, Yogyakarta

Rahmat, E.S., dan Setianingrum. 2001. Pengaruh Ekstrak Temu Lawak (Curcuma xanthorrhiza Roxb) untuk Meningkatkan Nafsu Makan pada Penderita Anoreksia Primer, Laporan Penelitian, Fakultas Kedokteran Universitas Diponegoro

Wulandari, N.A.N., Sugihartini, N., Mufrod. 2003. Formulasi Tablet Kunyah Klorokuin Difosfat dengan Bahan Pengisi Kombinasi Manitol-Laktosa. Media Farmasi : Jurnal Ilmu Farmasi.2:1-8



DOI: https://doi.org/10.22146/tradmedj.7748

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