Formulation and Evaluation of Water Fraction Hair tonic Containing Flavonoids from Ethanolic Extract of Green Tea Leaves (Camellia sinensis L.)

https://doi.org/10.22146/mot.53665

Elsa Fitria Apriani(1*), Adik Ahmadi(2), Vini Noviani(3)

(1) Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Sriwijaya University, South Sumatra, Indonesia
(2) Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Sriwijaya University, South Sumatra, Indonesia
(3) Magister of Pharmaceutical Sciences, Faculty of Pharmacy, Pancasila University, Jakarta, Indonesia, 12640
(*) Corresponding Author

Abstract


Hair growth tonics containing herbal and synthetic ingredients have been developed to overcome hair loss and baldness. Advanced technological developments made many Indonesians prefer to use herbal products compared to synthetic products due to their fewer side effects. Green tea leaves (Camellia sinensis L.) is a plant believed to increase hair growth rates due to its flavonoid compounds. The purpose of this study is to formulate hair tonic from water fraction ethanolic extract green tea leaves, to look at the activity of hair growth-promoting, and also to look at physical stability, irritation tests, and microbial contamination.  The positive control used is 2% Minoxidil. The hair growth activity test was carried out by applying a hair tonic to rabbits. Hair growth measurement data were statistically tested by the ANOVA test. The formulated green tea leaves tonic met the physical properties test. The tonic produces similar growth activities with the positive control (significance difference (p> 0.05)). In addition, the tonic does not have a skin irritation effect on rabbit skin and is free from bacteria.


Keywords


Green tea leaves; hair growth activity; water fraction; ethanolic extract; hair tonic formula

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References

Amin J., Simamora ELP., Anwar E., Djajadisastra J., 2014, Green Tea (Camellia sinensis, L.) Ethanolic Extract As Hair Tonic In Nutraceutical: Physical Stability, Hair Growth Activity On Rats, And Safety Test, International Journal of Pharmacy and Pharmaceutical Sciences, 6 (5), 94-99.

Amin SS., Sachdeva S., 2013, Alopecia areata: A review, Journal of the Saudi Society of Dermatology & Dermatologic Surgery, 17 (2), 37-45.

Bassino E., Gasparri F., Munaron L., 2020, Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review, Int. J. Mol. Sci, 21 (523), 1-17.

BPOM, 2014, Peraturan Kepala Badan Pengawasan Obat dan Makanan Republik Indonesia nomor 7 tahun 2014 tentang Pedoman Uji Toksisitas Nonklinik secara In Vivo, Badan Pengawasan Obat dan Makanan Republik Indonesia, Jakarta, pp. 55.

Kim HK., Choi SY., Chang HK., et al, 2012, Human skin safety test of green tea cell extracts in condition of allergic contact dermatitis, Toxicol Res, 28 (2), 113-116.

Kumar S., Singh N., Shweta, Archana, 2012, Green Tea Polyphenols : Versatile Cosmetic Ingredient, IJARPB, 2 (3), 348-362.

Lamria E., 2013, Uji Stabilitas Fisik, Aktivitas, Dan Keamanan Dari Sediaan Hair Tonic Yang Mengandung Ekstrak Etanol Teh Hijau (Camellia sinensis L) sebagai Nutrasetika, Skripsi, Fakultas Farmasi Universitas, Jakarta.

Messenger AG., Rundegren J., 2004, Minoxidil: Mechanism of Action on Hair Growth, British Journal of Dermatology, 150 (2), 186-194.

Noviani, V., Thauresia S., Apriani, E.F., & Simanjuntak, P., 2019, Hair Growth Promoting Activity of Green Tea Leaves (Camellia sinensis l.) Ethanolic Extract, Trad. Med. J., 24 (2), 104-109.

Shin S., Kim K., Lee MJ., et al., 2016, Epigallocatechin Gallate-Mediated Alteration of the MicroRNA Expression Profile in 5α-Dihydrotestosterone-Treated Human Dermal Papilla Cells, Ann Dermatol, 28 (3), 327-334.

Suchonwanit P., Thammarucha S., Leerunyakul K., 2019, Minoxidil and its use in hair disorders: a review, Drug Des Devel Ther, 13, 2777-2786.

Zhang H., Nan W., Wang S., et al, 2018, Epigallocatechin-3-Gallate Promotes the Growth of Mink Hair Follicles Through Sonic Hedgehog and Protein Kinase B Signaling Pathways, Front Pharmacol, 9 (674), 1-11.



DOI: https://doi.org/10.22146/mot.53665

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