Topical Anti-inflammatory Activity of Bangle (Zingiber cassumunar Roxb). Ethanolic Extract in Mice Induced By Carrageenan
Endang Dwi Wulansari(1*), Subagus Wahyuono(2), Marchaban Marchaban(3), Sitarina Widyarini(4)
(1) Stifar Yayasan Pharmasi Semarang
(2) Faculty of Pharmacy, Universitas Gadjah Mada
(3) Faculty of Pharmacy, Universitas Gadjah Mada
(4) Departement of Pathology, Faculty of Veterinary Medicine, Universitas Gadjah Mada
(*) Corresponding Author
Abstract
Rhizome of bangle (Zingiber cassumunar Roxb.) is one of the materials that are traditionally used in the traditional preparation to maintain skin from redness. The content of chemical compound in bangle rhizomes has many benefits, including inhibition of the inflammatory processes. This study aims to determine the topical anti-inflammatory activity of ethanolic extract of bangle rhizomes in mice induced by carrageenan. Thirty five female Swiss mice were used in this study. Animals were divided into 7 group of five: normal group, carrageenan 2% group, carrageenan 2% group plus control of basis (Biocream®), carrageenan 2% group plus 2.5% hydrocortisone cream, and carrageenan 2% group plus cream of ethanolic extract of bangle rhizomes with the concentration of 1%, 2.5% and 5% w/w. Carrageenan 2% was injected subcutaneously in all treatment group except normal group. The skinfold thickness of mice was measured every 1 hour for 6 hours after carrageenan injection. Results of this study shows that there is a significant differences between treatment groups (p <0.05) compared to carrageenan 2% treated group. To conclude, ethanolic extract of bangle rhizomes has topical anti-inflammatory in mice induced by carrageenan.
Keywords
Full Text:
PDFReferences
Bhuiyan, M.N.I., Chowdhury J.U. & Begum, J., 2008, Volatile constituents of essential oils isolated from leaf and rhizome of Zingiber cassumunar Roxb., Bangladesh J Pharmacol, 3: 69-73
Bin J.I., Mohd Y.M.S., Chin C.B. & Sim N,L., 2003, Antifungal activity of the essential oils of nine Zingiberaceae species, Pharm Biol, 41: 392–97
Boakye-Gyasi, E., Woode, E., Ainooson, G.K., Obiri, D.D., Ansah, C., Duwejua, M. & Donkoh, A., 2008, Anti-Inflammatory and antipyretic effects of an ethanolic extract of Palisota hirsuta K. Schum roots, Afr. J. Pharm. Pharmacol, 2 (9) : 191-199
Chaiwongsa, R., Ongchai, S., Boonsing, P., Kongtawelert, P., Panthong, A. & Reutrakul, V., 2013, Active Compound Of Zingiber Cassumunar Roxb. Down-Regulates The Expression Of Genes Involved In Joint Erosion In A Human Synovial Fibroblast Cell Line, Afr J Tradit Complement Altern Med., 10 (1) :40‐48
Fakhrudin, N., Putri, P.S., Sutomo, & Wahyuono, S., 2013, Aktivitas Antiinflamasi Ekstrak Metanolik Buah Mangga Kasturi (Mangifera casturi) Melalui Penghambatan Migrasi Leukosit Pada Mencit Yang Diinduksi Thioglikolat, Trad. Med. J., 18 (3) : 151-156
Han, A.R., Kim, M.S., Jeong, Y.H., Lee, S.K. & Seo, E.K., 2005, Cyclooxygenase-2 Inhibitory Phenylbutenoids from the Rhizomes of Zingiber cassumunar, Chem. Pharm. Bull., 53 (11) : 1466—1468
Ikawati, Z., Supardjan, A.M., & Asmara, L.S., 2006, Pengaruh Senyawa Heksagamavunon-I (HGV-1) terhadap inflamasi akut akibat reaksi anafilaksis kutaneus aktif pada tikus wistar jantan terinduksi ovalbumin, Prosiding Kemajuan Terkini Penelitian Klaster Kedokteran Kesehatan Universitas Gadjah Mada tahun 2006, ISBN no. 979-15614-3-5, hal. 131-145
Jeenapongsa, R., Yoovathaworn, K., Sriwatanakul K.M., Pongprayoon U., & Sriwatanakul K., 2003, Anti-inflammatory activity of (E)-1-(3,4-dimethoxyphenyl butadiene from Zingiber cassumunar Roxb., Journal of Ethnopharmacology, 87 : 143-148
Kaewchoothong, A., Tewtrakul, S. & Panichayupakaranant, P., 2012, Inhibitory Effect of Phenylbutanoid-rich Zingiber cassumunar Extracts on Nitric Oxide Production by Murine Macrophage-like RAW264.7 Cells, Phytother. Res., DOI: 10.1002/ptr.4661
Nakamura, S., Iwami, J., Matsuda, H., Wakayama, H., Pongpiriuadacha, Y. & Yoshikawa, M., 2009, Structures of New Phenylbutanoids and Nitric Oxide Production Inhibitors from the Rhizomes of Zingiber cassumunar, Chem. Pharm. Bull. 57 (11) : 1267—127
Nijveldt, R., Nood, E.V., Hoorn, D.EC.V., Boelens, P.G., Norren, K.V., dan Leeuwen, P.AM.V., 2001, Flavonoids: a review of probable mechanisms of action and potential aplications, Am J Clin Nutr, 75 : 418-425
Tangyuenyongwatana, P., Keeratinijakal, V. & Gritsanapan, W., 2012, Thin-Layer Chromatography-Densitometry Analysis of Dimethoxyphenylbutadiene Content in Zingiber cassumunar Rhizomes, Journal of AOAC International, 95 (6) : 1614 – 161
Taroeno, Brophy J.J. & Zwaving J.H., 1991, Analysis of the Essential Oil of Zingiber cassumunar Roxb. from Indonesia, Flavour And Fragrance Journal, 6 : 161-163
Widyarini, S., Spinks, N., Husband, A.J., & Reeve, V.E., 2001, Isoflavonoid Compounds from Red Clover (Trifolium pretense) Protect from Inflammation and Immune Supression Induced by UV Radiation, Photochem. Photobiol, 74. (3) : 465-470
Wulansari E.D., Wahyuono S., Marchaban & Widyarini S., 2016, Potential Bengle (Zingiber cassumunar Roxb.) Rhizomes For Sunscreen and Antioxidant Compounds, International Journal of PharmTech Research, 9 (11) : 72-77
DOI: https://doi.org/10.22146/mot.34640
Article Metrics
Abstract views : 6022 | views : 12519Refbacks
- There are currently no refbacks.
Copyright (c) 2018 Majalah Obat Tradisional
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Faculty of Pharmacy
Universitas Gadjah Mada