Physical and Chemical Stability Test of SNEDDS (Self-nanoemulsifying Drug Delivery System) and Nanoemulsion Ethyl Acetate Fraction of Garcinia mangostana L.

https://doi.org/10.22146/mot.28533

Liza Pratiwi(1*), Achmad Fudholi(2), Ronny Martien(3), Suwidjiyo Pramono(4)

(1) Pharmacy Departement, Faculty of Medical, Tanjungpura University Pontianak, Indonesia
(2) Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta
(3) Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta
(4) Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author

Abstract


The mangosteen peels (Garcinia mangostana L.) has high free radical scavengers activity. This study aims to determine the physical and chemical conditions that are formulated in SNEDDS and nanoemulsion preparations. SNEDDS was made with various concentrations of Tween 80, PEG 400, and Virgin Coconut Oil (VCO) with a ratio of 4,98:1,02:1. Nanoemulsions were made with the addition of water to SNEDDS. Stability observation results were analyzed by statistics. The results of physical stability test show that all test samples in the research, in nanoemulsion, SNEDDS fraction, base SNEDDS, SNEDDS vitamin E did not undergo separation, precipitation, cracking, and creaming. On the chemical stability test of nanoemulsion and SNEDDS fraction there is no difference between IC50 before and after storage. While on basic SNEDDS and vitamin E nanoemulsion there is a difference between IC50 before and after storage.

Keywords


stabilitas; kulit manggis; nanoemulsi; stability; mangosteen peels; SNEDDS; nanoemulsion

Full Text:

PDF


References

Ansel, H.C., 1989. Pengantar Bentuk Sediaan Farmasi, ed 4, Penerjemah Farida Ibrahim, Universitas Indonesia Press, Jakarta. Hal.155-164.

Badran, M.M., Taha, E.I., Tayel, M.M., dan Al-Suwayeh, S.A., 2014. Ultra-fine self nanoemulsifying drug delivery system for transdermal delivery of meloxicam: Dependency on the type of surfactants. Journal of Molecular Liquids, 190: 16–22.

Constantinides, P.P., dan Scalart, J.P. 1997. Int. J. Pharm,158: 57–68.

Date, A.A., Desai, N., Dixit, R., dan Nagarsenker, M., 2010. Self-nanoemulsifying drug delivery systems: formulation insights, applications and advances. Nanomed, 5: 1595–1616.

Kassem, A., Mohsen, A.M., Ahmed, R.S., dan Essam, T.M. 2016. Self-nanoemulsifying drug delivery sytem (SNEDDS) with enhanced solubilization of nystatin for treatment of oral candidiasis: Design, optimization, in vitro and in vivo evaluation. Journal of Molecular Liquids, 218: 219–232.

Koroleva, M. Y., dan Yurtov, E. V. 2012. Nanoemulsions: the properties, methods of preparation and promising applications. Russian Chemical Reviews, 81 (1), 21-43.

Lachman, L., Lieberman, H. A., dan Kanig, J. L. 1986, Teori dan Praktek Farmasi Industri, Edisi ketiga, diterjemahkan oleh: Suyatmi, S., Penerbit Universitas Indonesia, Jakarta. Hal. 760 -779, 1514 -1587.

Martin, A., Swarbick, J., Cammarata, A., 1993. Farmasi Fisik: Dasar-dasar farmasi fisik dalam ilmu farmasetik. Universitas Indonesia. Hal. 1147.

McClements, D.J., 2012. Nanoemulsions versus Microemulsions: Terminology, Differences, and Similarities. Soft Matter, 8: 1719-1729.

Nazzal, S., dan Khan, M.A. 2002. Response surface methodology for the optimization of ubiquinone self-nanoemulsified drug delivery system. AAPS PharmSciTech, 3: 23–31.

Nurliyana, R., Syed Z.I., Mustapha S.K., Aisyah, M.R., dan Kamarul R.K. 2010. Antioxidant study of pulp and peel dragon fruits: a comparative study. Int. Food Res. J. 17: 365-375.

Osol, A., 1980., Remington's Pharmaceutical Sciences, l6th ed, Mack Publishing Company, Easton-Pensivania. Hal.104-135, 244-262.

Parmar, N., Singla, N., Amin, S., dan Kohli, K., 2011. Study of cosurfactant effect on nanoemulsifying area and development of lercanidipine loaded (SNEDDS) self nanoemulsifying drug delivery system. Colloids and Surfaces B: Biointerfaces, 86: 327–338.

Pouton, C.W., 2000. Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and self-microemulsifying drug delivery systems. Eur. J. Pharm. Sci, 11: 93–98.

Pouton, C.W. dan Porter, C.J.H., 2008. Formulation of lipid-based delivery systems for oral administration: Materials, methods and strategies. Advanced Drug Delivery Reviews, 60: 625–637.

Senapati, P.C., Sahoo, S.K., dan Sahu, A.N., 2016. Mixed surfactant based (SNEDDS) self-nanoemulsifying drug delivery system presenting efavirenz for enhancement of oral bioavailability. Biomedicine & Pharmacotherapy, 80: 42–51.

Shafiq-un-Nabi, S., Shakeel, F., Talegaonkar, S., Ali, J., Baboota, S., Ahuja, A., dkk., 2007. Formulation development and optimization using nanoemulsion technique: a technical note. AAPS pharmscitech, 8: E12–E17.




DOI: https://doi.org/10.22146/mot.28533

Article Metrics

Abstract views : 7020 | views : 50559

Refbacks

  • There are currently no refbacks.


Bookmark and Share


Copyright (c) 2018 Majalah Obat Tradisional

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

©Majalah Obat Tradisional (Traditional Medicine Journal)
 ISSN 2406-9086
Faculty of Pharmacy
Universitas Gadjah Mada