Numerical Study of Fluid Dynamics in Suspension Culture of iPS Cells
Masaki Yano(1*), Takuya Yamamoto(2), Yasunori Okano(3), Toshiyuki Kanamori(4), Mashiro Kino–oka(5)
(1) Gradient School of Engineering Science, Osaka University, Machikaneyama 1-3, Toyonaka, Osaka 560-8531, Japan
(2) Gradient School of Engineering Science, Osaka University, Machikaneyama 1-3, Toyonaka, Osaka 560-8531, Japan
(3) Gradient School of Engineering Science, Osaka University, Machikaneyama 1-3, Toyonaka, Osaka 560-8531, Japan
(4) Biotechnology Research Institute for Drug Discovery, National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba Center 5th, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8565, Japan
(5) Gradient School of Engineering, Osaka University, Yamadaoka 2-1, Suita, Osaka 565-0871, Japan
(*) Corresponding Author
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- Adamo, L., Naveiras, O., Wenzel, P.L., McKinney-Freeman, S., Mack, P.J., Gracia-Sancho, J., Sunchy-Dicey, A., Yoshimoto, M., Lensch, M.W., Yoder, M.C., Garcia-Cardena, G. and Daley, G.Q. (2009). Biomechanical forces promote embryonic haematopoiesis, Nature., 459, 11311137.
- Ali, B.A., Borner, M., Peglow, M., Janiga, G., Seidel-Morgenstern, A. and Thevenin, D. (2015). Coupled computational fluid dynamics-discrete element method simulations of a pilot- scale batch crystallizer, Cryst. Growth Des., 15, 145155.
- Issa, R.I. (1986). Solution of the implicitly discretized fluid flow equations by operator-splitting, J. Comput. Phys., 62, 4065.
- Jing, L., Kwok, C.Y., Leung, Y.F. and Sobral, Y.D. (2016). Extended CFD-DEM for free-surface flow with multi-size granules, Int. J. Numer. Anal. Methods. Geomech., 40, 6279.
- Olmer, R., Haase, A., Merkert, S., Cui, W., Palecek, J., Ran, C., Kirschning, A., Scheper, T., Glage, S., Miller, K., Curnow, E. C., Hayes, E.S. and Martin, U. (2010). Long term expansion of undifferentiated human iPS and ES cells in suspension culture using a defined medium, Stem Cell Res., 5, 5164.
- Olmer, R., Lage, S., Selzer, A., Kasper, C., Haverich, A., Martin, U. and Tomoda, K. (2012). Suspension culture of human pluripotent stem cells in controlled, stirred bioreactors, J. Tissue. Eng., 18, 772784.
- OpenFOAM; http://www.openfoam.com for the open source CFD tool box.
- Otsuji, T.G., Bin, J., Yoshimura, A., Tomura, M., Tateyama, D., Minami, I., Yoshikawa, Y., Aiba, K., Heuser, J. E., Nishino, T., Hasegawa, K. and Nakatsuji, N. (2014). A 3D sphere culture system containing functional polymers for large-scale human pluripotent stem cell production, Stem Cell Rep., 2, 734745.
- Rusche, H. (2002). Computational fluid dynamics of dispersed two-phase flows at high phase fractions, Ph. D. Thesis., Imperial College of Science, Technology and Medicine.
- Salek, M.M., Sattari, P. and Martinuzzi, R.J. (2012). Analysis of fluid flow and wall shear stress patterns inside partially filled agitated culture well plates, Ann. Biomed. Eng., 40, 707728.
- Sargent, C.Y., Berguig, G. Y., Kinney, M.A., Hiatt, L. A., Carpenedo, R.L., Berson, R.E. and McDevitt, T.C. (2010). Hydrodynamic modulation of embryonic stem cell differentiation by rotary orbital suspension culture, Biotechnol. Bioeng., 105, 611626.
- Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K. and Yamanaka, S. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors, Cell., 131, 861872.
- Zalc, J.M., Alvarez, M.M., Muzzio, F.J. and Arik, B.E. (2001). Extensive validation of computed laminar flow in a stirred tank with three rushton turbines, Chem. Eng. Sci., 47, 21442154.
DOI: https://doi.org/10.22146/ajche.49567
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ASEAN Journal of Chemical Engineering (print ISSN 1655-4418; online ISSN 2655-5409) is published by Chemical Engineering Department, Faculty of Engineering, Universitas Gadjah Mada.