Artikel penelitian
Vol 15 No 1 (2021): Volume 15, Number 1, 2021
Kinetics study of paracetamol production from para-aminophenol and acetic anhydride
Department of Chemical Engineering, Faculty of Engineering, Universitas Gadjah Mada, Jl Grafika No. 2 Kampus UGM, 55281 Yogyakarta
Department of Chemical Engineering, Faculty of Engineering, Universitas Gadjah Mada, Jl Grafika No. 2 Kampus UGM, 55281 Yogyakarta
Faculty of Pharmacy, Universitas Gadjah Mada, Jl Sekip Utara Kampus UGM, 55281 Yogyakarta
Faculty of Pharmacy, Universitas Gadjah Mada, Jl Sekip Utara Kampus UGM, 55281 Yogyakarta
Department of Chemical Engineering, Faculty of Engineering, Universitas Gadjah Mada, Jl Grafika No. 2 Kampus UGM, 55281 Yogyakarta
Faculty of Pharmacy, Universitas Gadjah Mada, Jl Sekip Utara Kampus UGM, 55281 Yogyakarta
Department of Chemical Engineering, Faculty of Engineering, Universitas Gadjah Mada, Jl Grafika No. 2 Kampus UGM, 55281 Yogyakarta
Faculty of Pharmacy, Universitas Gadjah Mada, Jl Sekip Utara Kampus UGM, 55281 Yogyakarta
Faculty of Science and Technology, Universitas Peradaban, Jl Raya Pagojegan Km 3, Paguyangan, Brebes, Jawa Tengah
Abstrak
Dalam sepuluh tahun terakhir ini, Indonesia bertekad mengurangi impor bahan baku farmasi. Salah satu upaya yang dilakukan adalah membangun fasilitas produksi parasetamol yang akan mulai beroperasi pada tahun 2024. Studi kinetika diperlukan sebagai dasar perancangan reaktor parasetamol. Oleh karena itu, penelitian ini mengkaji kondisi operasi optimal pada reaksi produksi parasetamol yang akan dibutuhkan sebagai dasar perancangan pabrik. Pada percobaan ini, para-aminofenol direaksikan dengan anhidrida asetat dengan media air. Rasio mol para-aminofenol terhadap asetat anhidrida divariasikan 1:1 1:1,2, 1:1,5, dan 1:2 sedangkan temperatur divariasikan 80 °C, 90 °C, dan 110 °C. Akan tetapi, karena panas reaksi yang tidak dikontrol dan batasan berupa titik didih dari campuran reaksi, temperatur aktual reaksi menjadi 86 °C, 90 °C, dan 108 °C. Selain itu, kecepatan putaran pengadukan juga divariasikan pada angka 250 RPM dan 350 RPM. Kromatografi lapis tipis (KLT) dan densitometri digunakan untuk menentukan konsentrasi parasetamol dalam campuran reaksi. Temperatur, rasio mol reaktan, dan kecepatan putaran pengadukan yang optimum pada penelitian ini masing-masing adalah 110 °C, 1:1,5, dan 350 RPM. Selain itu, reaksi yang dilakukan dengan kondisi operasi tersebut menghasilkan konstanta laju reaksi 1,95 L mol-1 menit-1.
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