Comparison  ondansetron and domperidon as antiemetic for gastroenteritis in children: a review

Mardiana Siregar; Chairun Wiedyaningsih; Rina Mutiara

doi:10.22146/ijpther.11716

Mardiana Siregar Master of Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta
Chairun Wiedyaningsih Master of Clinical Pharmacy, Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta
Rina Mutiara Departement Pharmacy, Dr. Cipto Mangunkusumo National Central Public Hospital, Jakarta

DOI: https://doi.org/10.22146/ijpther.11716

Keywords: ondansetron, domperidone, gastroenteritis, vomiting, efficacy

Abstract

Gastroenteritis (GE) is the leading cause of vomiting in children. It is the main reason children admitted into emergency departments (EDs). Vomiting can cause fluid loss therefore oral rehydration solution (ORT) is recommended as supportive care for mild to moderate dehydration. Antiemetic therapy for GE is not fully recommended by any management guidelines. However, in some studies, antiemetics including ondansetron and domperidone are used in vomiting-related GE. This review aimed to compare ondansetron and domperidone for the treatment of GE in children. The article search was performed to identify relevant publications using PubMed database PubMed. PRISMA flow diagram was used as protocol during the article screening process. Eight

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