Betain and Alcohol-based Deep Eutectic Solvents for Vitexin Extraction from Binahong (Anredera cordifolia) Leaves

  • Kamarza Mulia Department of Chemical Engineering, Universitas Indonesia, Depok, 16424, Indonesia
  • Elsa A. Krisanti Department of Chemical Engineering, Universitas Indonesia, Depok, 16424, Indonesia
  • Geraldi Andika Department of Chemical Engineering, Universitas Indonesia, Depok, 16424, Indonesia
Keywords: deep eutectic solvent, extraction, betain, vitexin, binahong leaves, Anredera cordifolia

Abstract

Deep eutectic solvents (DESs) consisting of betaine as the hydrogen donor acceptor and a propanediol or a butanediol as the hydrogen bonding donor were used to extract vitexin from the leaves of Anredera cordifolia (Ten.) Steenis, known in Indonesia as binahong used traditionally to treat wounds. The vitexin extraction yields depend strongly on the molecular structure of the hydrogen bonding donor used and the betaine to alcohol molar ratio. The highest extraction yield of 0.024%, w/w vitexin in binahong leaves, was obtained at room temperature using the mixture of betaine and 1,3-propanediol in 1:4 mole ratio. For each set of DESs having a common HBD, the highest extraction yield was consistently obtained using the DES having betaine to alcohol molar ratio of 1:4. A higher extraction yield of 0.042% was obtained as the extraction temperature was increased to 40 °C. This study shows that DESs made of betaine and polyalcohol are prospective green solvents for extraction of bioactives such as vitexin from plants.

References

1. Baker, E.L. (1994). A review of recent research on health effects of human occupational exposure to organic solvents. A critical review. J Occup Med, 36(10)1079-1092.
2. Earle, M. J. & Seddon, K. R. (2000). Ionic Liquids: Green Solvents for the Future. Pure Appl Chem, 72 (7) 1391-1398.
3. Can, O. D., Demir, O. U. & Ucel, U. I. (2013) Anti-depressant-like effect of vitexin in BALB/c mice and evidence for the involvement of monoaminergic mechanisms.Eur J Pharma, 699, 250-257.
4. Dai Y., van Spronsen J., Witkamp G.J., Verpoorte R., Choi Y.H. (2013a) Natural deep eutectic solvents as new potential media for green technology. Anal Chim Acta, 766, 61-68.
5. Dai, Y., Witkamp, G.-J., Verpoorte, R. Choi Y.H.(2013b) Natural Deep Eutectic Solvents as a New Extraction Media for Phenolic Metabolites in CarthamustinctoriusL, Anal. Chem. 85, 6272-6278.
6. He, M., Min, J-W, Kong, W-L, He, X-H., Li, J-X. Peng, B-W. (2016) A review on the pharmacological effects of vitexin and isovitexin, Fitoterapia, 115 (Supplement C), 74-85.
7. Ogihara, W., Aoyama, T., Ohno, H. (2004) Polarity Measurement for Ionic Liquids Containing Dissociable Protons. Chemistry Letters. 33 (11) 1414-1415.
8. Zhu, J., Yu, K., Zhu, Y., Zhu, R., Ye, F., Song, N., Xu, Y. (2017) Physicochemical properties of deep eutectic solvents formed by choline chloride and phenolic compounds at T = (293.15 to 333.15) K: The influence of electronic effect of substitution group, J. Mol. Liq.232, 182-187
Published
2023-12-31
How to Cite
Mulia, K., Krisanti, E. A., & Andika, G. (2023). Betain and Alcohol-based Deep Eutectic Solvents for Vitexin Extraction from Binahong (Anredera cordifolia) Leaves. ASEAN Journal of Chemical Engineering, 18(2), 1-6. Retrieved from https://dev.journal.ugm.ac.id/v3/AJChE/article/view/9018
Section
Articles