Differences in results of infrabony pocket treatment with addition of platelet rich fibrin and platelet rich plasma gel in DFDBA bone graft

https://doi.org/10.22146/majkedgiind.37423

Netta Anggraini(1), Sri Pramestri Lastianny(2*), Al Sri Koes Soesilowati(3)

(1) Departement of Periodontics, Faculty of Dentistry, Universitas Baiturrahmah, Padang, West Sumatra Periodontics Specialty Program, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta
(2) Departement of Periodontics, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta
(3) Departement of Periodontics, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta
(*) Corresponding Author

Abstract


Treatment of infrabony pocket makes use of bone graft material demineralized freeze dried bone allograft (DFDBA) from different individuals which has undergone demineralization process and it is osteoinductive. Enhancement of growth factor was done by adding platelet rich fibrin (PRF) and platelet rich plasma (PRP). PRP is activated with an addition of calcium chloride CaCl2) to form gel. The method used to apply the bone grafting material is open flap debridement OFD). This research aimed to reveal the differences in the results of infrabony pocket treatment using PRF and PRP gel with an addition of DFDBA. The sample was taken from 20 infrabony pocket points divided into 2 groups, 10 infrabony pocket were treated with OFD+DFDBA+PRF and the other were treated with OFD+DFDBA+PRP gel. Pocket depth (PD) was measured on the baseline and the first and third month after treatment. Alveolar bone height was measured using cone beam computed tomography (CBCT) radiograph on the baseline to the third month after treatment. The results of this research showed that there was difference in the results of infrabony pocket treatment using PRF and PRP gel with an addition of DFDBA which could be observed from a reduction in PD from the baseline, month 1 and month 3 as well as reduction in alveolar bone height from the baseline to month 3. This research concluded that infrabony pocket treatment PRF application yields better results than PRP gel application in terms of PD and alveolar bone height reduction.

Keywords


DFDBA; infrabony pocket; open flap debridement; PRF; PRP gel

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References

1. Newman MG, Takei HH, Carranza FA, Klokkevold PR. Carranza‘s Clinical
Periodontology 11th ed. Philadelphia: W.B. Saunders Co; 2012. 550-555, 587.

2. Xiang-Ying O, Jing Q. Effect of plateletrich plasma in the treatment of periodontal
intrabony defects in humans. Chin Med J (Engl). 2006; 119(18): 1511-1521.

3. Kumar RV, Shubhashini N. Platelet rich fibrin: a new paradigm in periodontal regeneration.
Cell Tissue Bank. 2012; 14(3): 453–463. doi: 10.1007/s10561-012-9349-6

4. Ouyang XY, Qiao J. Effect of platelet-rich plasma in the treatment of periodontal infrabony defects in humans. Chinese Medical Journal. 2006; 119(18): 1511-1521. doi: 10.1097/00029330-200609020-00003

5. Rodriguez IA, Kalaf EA, Bowlin GL, Sell SA. Platelet-Rich plasma in bone regeneration:
engineering the delivery for improved clinical efficacy. Biomed Res Int. 2014; 2014: 392398.
doi: 10.1155/2014/392398

6. Bender SA, Rogalski JB, Mills MP, Arnold RM, Cochran DL, Mellonig JT. Evaluation
of demineralized bone matrix paste and putty in periodontal intraosseous defects. J Periodontol. 2005; 76(5): 768–777. doi: 10.1902/jop.2005.76.5.768

7. Guo S, DiPietro LA. Factors affecting wound healing. J Dent Res. 2010; 89(3): 219-229.
doi: 10.1177/0022034509359125

8. Giele H, Cassell O. Plastic and reconstructive surgery. Oxford Specialist Handbook in
Surgery; 2008.

9. Dohan DM, Choukroun J, Diss A, Dohan SL, Dohan AJ, Mouhyi J, Gogly B. Platelet-Rich
Fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts
and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006; 101(3): e37-44. doi: 10.1016/j.tripleo.2005.07.008

10. Lee KS, Wilson JJ, Rabago DP, Baer GS, Jacobson JA, Borrero GC. Musculosceletal
applications of platelet-rich plasma: fad or future? AJR Am J Roentgenol. 2011; 196(3): 628-636. doi: 10.2214/AJR.10.5975

11. So SG, Lee JY, Park JB, Kim HC, Park IH, Lee SC. Using autologous thrombin in making
prp gel –case reports-. Living Well Institute of Dental Research. 2011; 60-69.

12. Raja V Sunitha, Naidu E Murinatham. 2008. Platelet-rich Fibrin: Evolution of a second-
generation platelet concentrate. Indian Journal of Dental Research, 2008; 19(1):42-46

13. Javed F, Askar MA, Rasheed AA, Hezaimi KA. Significance of the paltelet-derived growth
factor in periodontal tissue regeneration. Arch Oral Biol. 2011; 56(12): 1476-1484. doi: 10.1016/j.archoralbio.2011.06.020



14. Lindhe J, Lang NP, Karring T. Clinical Periodontology and Implant Dentistry. 5 th ed. United Kingdom: Blackwell Munksgard; 2008. 57-59.



15. Yilmaz S, Cakar G, Ipci SD. Platelet rich plasma in reconstructive periodontal therapy.
Platelets. 2011; 23: 269-290. doi: 10.5772/22967

16. Toit JD, Gluckman H, Salama M. Platelet-Rich Fibrin (PRF): a growth factor-rich biomaterial.
part 1 - the platelet concentrates milieu & review of the literature. International Dentistry
- African Edition. 2015; 5(5): 62-70.




DOI: https://doi.org/10.22146/majkedgiind.37423

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